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Akademický článek

Upregulation of ALOX12−12-HETE pathway impairs AMPK-dependent modulation of vascular metabolism in ApoE/LDLR−/− mice

Autor: Mariola Olkowicz, Agnieszka Karas, Piotr Berkowicz, Patrycja Kaczara, Agnieszka Jasztal, Zuzanna Kurylowicz, Filip Fedak, Hernando Rosales-Solano, Kanchan Sinha Roy, Agnieszka Kij, Elzbieta Buczek, Janusz Pawliszyn, Stefan Chlopicki

Publikováno v: Pharmacological Research, Vol 210, Iss , Pp 107478- (2024)

Mitochondrial dysfunction and 12-lipoxygenase (ALOX12)-derived 12(S)-HETE production have been associated with vascular inflammation and the pathogenesis of atherosclerosis. However, the role of ALOX12 in regulating vascular energy metabolism in vasc

Externí odkaz: https://doaj.org/article/8ca22da45ba24b6e961c7c33ebd74e00

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Akademický článek

Prospective analysis: does ice bathing harden against COVID-19 and is B RhD- the least viral resistant blood group in Polish ice bathers?

Autor: Andrzej Tukiendorf, Łukasz Wysoczański, Paulina Wysoczańska, Marcus Lancé, Piotr Feusette, Zbigniew Szczepanowski, Sylwia Michalak, Wawrzyniec Mantorski, Julia Mardusińska, Edyta Wolny-Rokicka, Maria Bujnowska-Fedak

Publikováno v: Family Medicine & Primary Care Review, Vol 26, Iss 2, Pp 231-238 (2024)

Externí odkaz: https://doaj.org/article/5db7d13b30604db681f8b65152ac5992

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Akademický článek

Optimizing 5’UTRs for mRNA-delivered gene editing using deep learning

Autor: Sebastian Castillo-Hair, Stephen Fedak, Ban Wang, Johannes Linder, Kyle Havens, Michael Certo, Georg Seelig

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Abstract mRNA therapeutics are revolutionizing the pharmaceutical industry, but methods to optimize the primary sequence for increased expression are still lacking. Here, we design 5’UTRs for efficient mRNA translation using deep learning. We perfo

Externí odkaz: https://doaj.org/article/584216b48e674f71a733f6e57b2e7bc4

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Akademický článek

Novel CTD tag establishes shark fins as ocean observing platforms

Autor: Camille M. L. S. Pagniello, Michael R. Castleton, Aaron B. Carlisle, Taylor K. Chapple, Robert J. Schallert, Michael Fedak, Barbara A. Block

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)

Abstract Animal-borne tags are effective instruments for collecting ocean data and can be used to fill spatial gaps in the observing network. We deployed the first conductivity, temperature, and depth (CTD) satellite tags on the dorsal fin of salmon

Externí odkaz: https://doaj.org/article/913d5e773cd74871a39363f9267dde24

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