Zobrazeno 1 - 10
of 177
pro vyhledávání: '"A F, Hackett"'
Autor:
Valeria E. Lorenc, Raquel Lima e Silva, Sean F. Hackett, Seth D. Fortmann, Yuanyuan Liu, Peter A. Campochiaro
Publikováno v:
FASEB BioAdvances, Vol 2, Iss 4, Pp 219-233 (2020)
Abstract In patients with macular edema due to ischemic retinopathy, aqueous levels of hepatocyte growth factor (HGF) correlate with edema severity. We tested whether HGF expression and activity in mice with oxygen‐induced ischemic retinopathy supp
Externí odkaz:
https://doaj.org/article/55eb1a2a210e42579ab4fb3a085186e8
Autor:
Yogita Kanan, Sean F. Hackett, Henry T. Hsueh, Mahmood Khan, Laura M. Ensign, Peter A. Campochiaro
Publikováno v:
Free Radical Biology and Medicine. 198:118-122
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e22114ffadaf52b2a69a1d70a7bddcd
https://doi.org/10.1016/j.freeradbiomed.2023.01.021
https://doi.org/10.1016/j.freeradbiomed.2023.01.021
Publikováno v:
Gene therapy
Suprachoroidal injection provides a new route of delivery for AAV vectors to retinal pigmented epithelial cells and photoreceptors that can be done in an outpatient setting and is less invasive and potentially safer than subretinal injection, the mos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e5c06dca8c95985db3ffdf5791ad01
https://doi.org/10.1038/s41434-021-00233-1
https://doi.org/10.1038/s41434-021-00233-1
Autor:
Peter A. Campochiaro, Valeria E. Lorenc, Seth D. Fortmann, Sean F. Hackett, Yuanyuan Liu, Raquel Lima e Silva
Publikováno v:
FASEB BioAdvances
FASEB BioAdvances, Vol 2, Iss 4, Pp 219-233 (2020)
FASEB BioAdvances, Vol 2, Iss 4, Pp 219-233 (2020)
In patients with macular edema due to ischemic retinopathy, aqueous levels of hepatocyte growth factor (HGF) correlate with edema severity. We tested whether HGF expression and activity in mice with oxygen‐induced ischemic retinopathy supports a ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6b2b342a574242bfea2b380eb514f4b
https://doi.org/10.1096/fba.2019-00074
https://doi.org/10.1096/fba.2019-00074
Publikováno v:
Free Radic Biol Med
Retinitis pigmentosa occurs due to mutations that cause rod photoreceptor degeneration. Once most rods are lost, gradual degeneration of cone photoreceptors occurs. Oxidative damage and abnormal glucose metabolism have been implicated as contributors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db791e743ec134143b0ff875c777bdf7
https://europepmc.org/articles/PMC8891093/
https://europepmc.org/articles/PMC8891093/
Autor:
Jacob S Heng, Loyal A. Goff, Sean F. Hackett, Genevieve Stein-O’Brien, Briana L. Winer, John Williams, Jeremy Nathans
Publikováno v:
Proc Natl Acad Sci U S A
Autoimmune uveoretinitis is a significant cause of visual loss, and mouse models offer unique opportunities to study its disease mechanisms. Aire −/− mice fail to express self-antigens in the thymus, exhibit reduced central tolerance, and develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e03b73ed72a5559b7571485acc089ec
https://doi.org/10.1073/pnas.1915571116
https://doi.org/10.1073/pnas.1915571116
Autor:
Matthew D. Shin, Hyounkoo Han, Ian Pitha, Byung Jin Kim, Justin Hanes, Amy Xiao, Peter J. McDonnell, Sean F. Hackett, Henry T. Hsueh, Raquel Lima e Silva, Laura M. Ensign, Youngwook Kim, Yoo Chun Kim, Ping He, Laolu Ogunnaike, Albert S. Jun, Abhijit A. Date, Charles G. Eberhart, Nicole M. Anders, Avelina Hemingway, Peter A. Campochiaro, Donald J. Zack
Publikováno v:
Nature biomedical engineering. 4(11)
Eye-drop formulations should hold as high a concentration of soluble drug in contact with ocular epithelium for as long as possible. However, eye tears and frequent blinking limit drug retention on the ocular surface, and gelling drops typically form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::189653b8e1789d5606d8d04d277f524f
https://pubmed.ncbi.nlm.nih.gov/33159191
https://pubmed.ncbi.nlm.nih.gov/33159191
Autor:
Sean F. Hackett, S. Amer Riazuddin, Firoz Kabir, Muhammad Ali, Mei-Chong Wendy Lee, Ruiqiang Chen, Nader Pourmand, Chan Hyun Na, Shahid Y. Khan
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Scientific reports, vol 8, iss 1
Scientific Reports
Scientific reports, vol 8, iss 1
Scientific Reports
We previously investigated the transcriptome and proteome profiles of the murine ocular lens at six developmental time points including two embryonic (E15 and E18) and four postnatal time points (P0, P3, P6, and P9). Here, we extend our analyses to i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a432c641d82c8994f7b81e36b2a5c39
http://link.springer.com/article/10.1038/s41598-018-28727-w
http://link.springer.com/article/10.1038/s41598-018-28727-w
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
Scientific Reports
Scientific Reports
Vitreous or aqueous humour taps are widely used in patients or large animals with retinal diseases to monitor disease biomarkers, search for novel biomarkers, assess the integrity of the blood-retinal barrier, or perform pharmacokinetic or pharmacody
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d62e480042271fdec27b494364a0579
http://link.springer.com/article/10.1038/s41598-018-24197-2
http://link.springer.com/article/10.1038/s41598-018-24197-2
Autor:
Lorenzo Benatuil, Maria Harris, Gregory M. Preston, Gary Overmeyer, Shibo Tang, Susan Marchie, Peter A. Campochario, Jacqueline G. Bixby, Qing Chang, Ramesh Iyer, Jikui Shen, Kun Ding, Sahana Bose, Suju Zhong, Jijie Gu, Lucia Eaton, Diana Bowley, Christine Grinnell, Tariq Ghayur, Anca Clabbers, Matthew Rieser, Sean F. Hackett, Debra S. Touw, Deborah A. van Riet, Ramkrishna Sadhukhan, Feng Dong
Publikováno v:
mAbs. 9:269-284
Exudative age-related macular degeneration (AMD) is the most common cause of moderate and severe vision loss in developed countries. Intraocular injections of vascular endothelial growth factor (VEGF or VEGF-A)-neutralizing proteins provide substanti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9564621bbad9ee03f804e3aacbf89e63
https://doi.org/10.1080/19420862.2016.1268305
https://doi.org/10.1080/19420862.2016.1268305