An international guideline with six personalised titration schedules for preventing myocarditis and pneumonia associated with clozapine

Autor: Christopher Rohde, Christoph U Correll, Jose de Leon, Can-Jun Ruan, Georgios Schoretsanitis, Elif Anıl Yağcıoğlu, Trino Baptista, Oleg O Kirilochev, Carlos De las Cuevas

Publikováno v: General Psychiatry, Vol 35, Iss 3 (2022)

Externí odkaz: https://doaj.org/article/ecbbefb00c944a289bcbb0508ea6d2d0

Valproate, obesity and other causes of clozapine poor metabolism in the context of rapid titration may explain clozapine-induced myocarditis: A re-analysis of a Turkish case series

Autor: Aygün Ertuğrul, A. Elif Anıl Yağcıoğlu, Esen Ağaoğlu, Ahmet Alp Karakaşlı, Sertaç Ak, M. Kâzım Yazıcı, Jose de Leon

Publikováno v: Revista de Psiquiatría y Salud Mental. 15:281-286

Clozapine-induced myocarditis or any clozapine-induced inflammation may be a hypersensitivity reaction due to titration that was too rapid for the patient's clozapine metabolism. Clozapine metabolism is influenced by ancestry, sex, smoking and the pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46f926d31612a5f09e6fc8ecfcd20c1a
https://doi.org/10.1016/j.rpsm.2021.10.003

Combination With Long-Acting Injectable Antipsychotics and Utilization of Nonstandard Formulations as Compliance Enhancing Methods for Clozapine Users

Autor: Emre Mutlu, Melike Karaçam Doğan, Aygün Ertuğrul, A. Elif Anıl Yağcıoğlu

Publikováno v: Journal of Clinical Psychopharmacology. 42:298-307

Combining clozapine with a long-acting injectable antipsychotic (LAI) or using different, nonstandard formulations of the compound may improve treatment outcomes. We aimed to investigate the utility of the clozapine-LAI combination and different form

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4e8b5bfb9e898a9161e7965e4aadade
https://doi.org/10.1097/jcp.0000000000001526

The cognitive aspect of formal thought disorder and its relationship with global social functioning and the quality of life in schizophrenia

Autor: Esra Aki, Aygun Ertugrul, Hatice Abaoğlu, M Kazım Yazıcı, Elif Barışkın, Emre Mutlu, A. Elif Anıl Yağcıoğlu, S. Can Gurel

Publikováno v: Social Psychiatry and Psychiatric Epidemiology. 56:1399-1410

It was expected that using a comprehensive scale like the Thought and Language Disorder Scale (TALD) for measurement of FTD would enable assessing its heterogeneity and its associations with cognitive impairment and functionality. This study has aime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2903eca835fafbeafc48aba66d70d4ff
https://doi.org/10.1007/s00127-021-02024-w

An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels

Autor: Jose de Leon, Georgios Schoretsanitis, Robert L. Smith, Espen Molden, Anssi Solismaa, Niko Seppälä, Miloslav Kopeček, Patrik Švancer, Ismael Olmos, Carina Ricciardi, Celso Iglesias-Garcia, Ana Iglesias-Alonso, Edoardo Spina, Can-Jun Ruan, Chuan-Yue Wang, Gang Wang, Yi-Lang Tang, Shih-Ku Lin, Hsien-Yuan Lane, Yong Sik Kim, Se Hyun Kim, Anto P. Rajkumar, Dinora F. González-Esquivel, Helgi Jung-Cook, Trino Baptista, Christopher Rohde, Jimmi Nielsen, Hélène Verdoux, Clelia Quiles, Emilio J. Sanz, Carlos De Las Cuevas, Dan Cohen, Peter F.J. Schulte, Aygün Ertuğrul, A. Elif Anıl Yağcıoğlu, Nitin Chopra, Betsy McCollum, Charles Shelton, Robert O. Cotes, Arun R. Kaithi, John M. Kane, Saeed Farooq, Chee H. Ng, John Bilbily, Christoph Hiemke, Carlos López-Jaramillo, Ian McGrane, Fernando Lana, Chin B. Eap, Manuel Arrojo-Romero, Flavian Ş. Rădulescu, Erich Seifritz, Susanna Every-Palmer, Chad A. Bousman, Emmanuel Bebawi, Rahul Bhattacharya, Deanna L. Kelly, Yuji Otsuka, Judit Lazary, Rafael Torres, Agustin Yecora, Mariano Motuca, Sherry K.W. Chan, Monica Zolezzi, Sami Ouanes, Domenico De Berardis, Sandeep Grover, Ric M. Procyshyn, Richard A. Adebayo, Oleg O. Kirilochev, Andrey Soloviev, Konstantinos N. Fountoulakis, Alina Wilkowska, Wiesław J. Cubała, Muhammad Ayub, Alzira Silva, Raphael M. Bonelli, José M. Villagrán-Moreno, Benedicto Crespo-Facorro, Henk Temmingh, Eric Decloedt, Maria R. Pedro, Hiroyoshi Takeuchi, Masaru Tsukahara, Gerhard Gründer, Marina Sagud, Andreja Celofiga, Dragana Ignjatovic Ristic, Bruno B. Ortiz, Helio Elkis, António J. Pacheco Palha, Adrián LLerena, Emilio Fernandez-Egea, Dan Siskind, Abraham Weizman, Rim Masmoudi, Shamin Mohd Saffian, Jonathan G. Leung, Peter F. Buckley, Stephen R. Marder, Leslie Citrome, Oliver Freudenreich, Christoph U. Correll, Daniel J. Müller

Publikováno v: De Leon, J, Schoretsanitis, G, Smith, R L, Molden, E, Solismaa, A, Seppälä, N, Kopeček, M, Švancer, P, Olmos, I, Ricciardi, C, Iglesias-Garcia, C, Iglesias-Alonso, A, Spina, E, Ruan, C J, Wang, C Y, Wang, G, Tang, Y L, Lin, S K, Lane, H Y, Kim, Y S, Kim, S H, Rajkumar, A P, González-Esquivel, D F, Jung-Cook, H, Baptista, T, Rohde, C, Nielsen, J, Verdoux, H, Quiles, C, Sanz, E J, De Las Cuevas, C, Cohen, D, Schulte, P F J, Ertuǧrul, A, Anll Yaǧcloǧlu, A E, Chopra, N, McCollum, B, Shelton, C, Cotes, R O, Kaithi, A R, Kane, J M, Farooq, S, Ng, C H, Bilbily, J, Hiemke, C, López-Jaramillo, C, McGrane, I, Lana, F, Eap, C B, Arrojo-Romero, M, Rǎdulescu, F, Seifritz, E, Every-Palmer, S, Bousman, C A, Bebawi, E, Bhattacharya, R, Kelly, D L, Otsuka, Y, Lazary, J, Torres, R, Yecora, A, Motuca, M, Chan, S K W, Zolezzi, M, Ouanes, S, De Berardis, D, Grover, S, Procyshyn, R M, Adebayo, R A, Kirilochev, O O, Soloviev, A, Fountoulakis, K N, Wilkowska, A, Cubała, W J, Ayub, M, Silva, A, Bonelli, R M, Villagrán-Moreno, J M, Crespo-Facorro, B, Temmingh, H, Decloedt, E, Pedro, M R, Takeuchi, H, Tsukahara, M, Gründer, G, Sagud, M, Celofiga, A, Ignjatovic Ristic, D, Ortiz, B B, Elkis, H, Pacheco Palha, A J, Llerena, A, Fernandez-Egea, E, Siskind, D, Weizman, A, Masmoudi, R, Mohd Saffian, S, Leung, J G, Buckley, P F, Marder, S R, Citrome, L, Freudenreich, O, Correll, C U & Müller, D J 2022, ' An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels ', Pharmacopsychiatry, vol. 55, no. 2, pp. 73-86 . https://doi.org/10.1055/a-1625-6388

This international guideline proposes improving clozapine package inserts worldwide by using ancestry-based dosing and titration. Adverse drug reaction (ADR) databases suggest that clozapine is the third most toxic drug in the United States (US), and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c69e293db54415a8bfeda3a4a06ea2f
http://hdl.handle.net/20.500.12278/124424