Zobrazeno 1 - 10
of 60
pro vyhledávání: '"A E Maccubbin"'
Autor:
Jeanine A. Harrigan, James R. Olson, Chad M. Vezina, Barbara P. McGarrigle, Alexander E. Maccubbin, Harold C. Box, Noreen Ersing
Publikováno v:
Toxicological Sciences. 77:307-314
Chemical-DNA adducts provide an integrated measure of exposure, absorption, bioactivation, detoxification, and DNA repair following exposure to a genotoxic agent. Benzo[a]pyrene (BaP), a prototypical polycyclic aromatic hydrocarbon (PAH), can be bioa
Autor:
Edwin E. Budzinski, Herbert Iijima, Noreen Ersing, John C. Wallace, Harold C. Box, Jean B. Dawidzik, Alexander E. Maccubbin, Harold G. Freund, Helen B. Patrzyc
Publikováno v:
Archives of Biochemistry and Biophysics. 375:119-123
Evidence has been accumulating at the oligomer level that free radical-initiated DNA damage includes lesions in which two adjacent bases are both modified. Prominent examples are lesions in which a pyrimidine base is degraded to a formamido remnant a
Autor:
Harold C. Box, Edwin E. Budzinski, John C. Wallace, Alexander E. Maccubbin, Noreen Ersing, Herbert Iijima, Helen B. Patrzyc, Jean B. Dawidzik
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1454(1):80-88
A 32 P-postlabeling assay has been developed for the simultaneous detection of the thymine glycol lesion and the formamido remnant of pyrimidine bases in DNA exposed to reactive oxygen species (ROS). The formamido lesion is a principal lesion produce
Autor:
Srikanth S. Nadadur, Anuradha Mudipalli, Hira L. Gurtoo, Alexander E. Maccubbin, Noreen Ersing
Publikováno v:
Environmental and Molecular Mutagenesis. 29:143-151
Reductive activation of mitomycin C leads to its covalent binding to DNA, forming monoadducts and cross-links. The cytotoxicity of mitomycin C has been attributed to cross-link formation, whereas monoadducts are assumed to cause mutagenicity. We have
Publikováno v:
Environmental Science & Technology. 30:136-142
The ability of Sphingomonas paucimobilis, strain EPA 505 (a soil bacterium capable of utilizing fluoranthene as the sole source of carbon and energy for growth) to metabolize a variety of high molecular weight polynuclear aromatic hydrocarbons (PAHs)
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1161:291-294
The hydrolysis by nuclease P1 of the 16 common deoxydinucleoside monophosphates was examined. The rates of hydrolysis of phosphodiester bond differ by more than two orders of magnitude; dinucleotide monophosphates of the type d(TpN) being most resist
Autor:
Alexander E. Maccubbin, Noreen Ersing
Publikováno v:
Hydrobiologia. 219:301-306
Autor:
Alexander E. Maccubbin, Hank Kung, Shaheen M. Nakeeb, Elizabeth K. John, Ellen M. Schopp, Paul J. Kostyniak, Mark A. Green
Publikováno v:
Journal of Applied Toxicology. 10:417-421
Cu-PTSM is a potential imaging agent for the heart and brain when labeled with either 64Cu or 62Cu. Unlabeled Cu-PTSM was evaluated for its acute toxicity and mutagenicity. Cu-PTSM had an i.v. LD50 of 26 mg kg-1 in the rat and 2 mg kg-1 in the rabbit
Publikováno v:
Cancer Communications. 2:207-211
The cyclophosphamide metabolite, acrolein, was reacted with 2'-deoxyguanosine-3'-monophosphate, and two adducts were detected by high performance liquid chromatography and 32P-postlabeling assay. These adducts were resistant to dephosphorylation by n
Publikováno v:
Cancer research. 58(3)
Mitomycin C (MMC) is a DNA cross-linking agent that has been used in cancer chemotherapy for over 20 years, yet little is known either qualitatively or quantitatively about MMC-induced DNA adduct formation and repair in vivo. As an initial means of i