Zobrazeno 1 - 10
of 257
pro vyhledávání: '"A E Grigoriadis"'
Autor:
Jennifer C. Coleman, Luke Tattersall, Val Yianni, Laura Knight, Hongqiang Yu, Sadie R. Hallett, Philip Johnson, Ana J. Caetano, Charlie Cosstick, Anne J. Ridley, Alison Gartland, Maria R. Conte, Agamemnon E. Grigoriadis
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109288- (2024)
Summary: RNA-binding proteins (RBPs) are emerging as important regulators of cancer pathogenesis. We reveal that the RBPs LARP4A and LARP4B are differentially overexpressed in osteosarcoma and osteosarcoma lung metastases, as well as in prostate canc
Externí odkaz:
https://doaj.org/article/e05b9197d6e846339a41025635e63f0c
Autor:
Thomas GP Grünewald, Marta Alonso, Sofia Avnet, Ana Banito, Stefan Burdach, Florencia Cidre‐Aranaz, Gemma Di Pompo, Martin Distel, Heathcliff Dorado‐Garcia, Javier Garcia‐Castro, Laura González‐González, Agamemnon E Grigoriadis, Merve Kasan, Christian Koelsche, Manuela Krumbholz, Fernando Lecanda, Silvia Lemma, Dario L Longo, Claudia Madrigal‐Esquivel, Álvaro Morales‐Molina, Julian Musa, Shunya Ohmura, Benjamin Ory, Miguel Pereira‐Silva, Francesca Perut, Rene Rodriguez, Carolin Seeling, Nada Al Shaaili, Shabnam Shaabani, Kristina Shiavone, Snehadri Sinha, Eleni M Tomazou, Marcel Trautmann, Maria Vela, Yvonne MH Versleijen‐Jonkers, Julia Visgauss, Marta Zalacain, Sebastian J Schober, Andrej Lissat, William R English, Nicola Baldini, Dominique Heymann
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 11, Pp 1-33 (2020)
Abstract Sarcomas are heterogeneous and clinically challenging soft tissue and bone cancers. Although constituting only 1% of all human malignancies, sarcomas represent the second most common type of solid tumors in children and adolescents and compr
Externí odkaz:
https://doaj.org/article/32421af97ff64f339c73c8bfd6f57409
Autor:
Mario M. Zaiss, Christopher Hall, Neil W. A. McGowan, Rebecca Babb, Vikesh Devlia, Sébastien Lucas, Sajeda Meghji, Brian Henderson, Aline Bozec, Georg Schett, Jean‐Pierre David, Gabriel S. Panayi, Agamemnon E. Grigoriadis, Valerie M. Corrigall
Publikováno v:
ACR Open Rheumatology, Vol 1, Iss 6, Pp 382-393 (2019)
Objective The association between inflammation and dysregulated bone remodeling is apparent in rheumatoid arthritis and is recapitulated in the human tumor necrosis factor transgenic (hTNFtg) mouse model. We investigated whether extracellular binding
Externí odkaz:
https://doaj.org/article/04a0f51a530f4d1b9dd2c2df372d1a40
Autor:
Silvia A. Ferreira, Meghna S. Motwani, Peter A. Faull, Alexis J. Seymour, Tracy T. L. Yu, Marjan Enayati, Dheraj K. Taheem, Christoph Salzlechner, Tabasom Haghighi, Ewa M. Kania, Oommen P. Oommen, Tarek Ahmed, Sandra Loaiza, Katarzyna Parzych, Francesco Dazzi, Oommen P. Varghese, Frederic Festy, Agamemnon E. Grigoriadis, Holger W. Auner, Ambrosius P. Snijders, Laurent Bozec, Eileen Gentleman
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
3D hydrogels have provided information on the physical requirements of stem cell fate, but the contribution of interactions with the pericellular environment are under-explored. Here the authors show that pericellular matrix secreted by human bone ma
Externí odkaz:
https://doaj.org/article/8af8d8a81ddc405d9f52c6d4512ee247
Autor:
Camille Jacques, Nathalie Renema, Frederic Lezot, Benjamin Ory, Carl R. Walkley, Agamemnon E. Grigoriadis, Dominique Heymann
Publikováno v:
Journal of Bone Oncology, Vol 12, Iss , Pp 7-13 (2018)
Osteosarcoma, Ewing sarcoma and chondrosarcoma are the three main entities of bone sarcoma which collectively encompass more than 50 heterogeneous entities of rare malignancies. In contrast to osteosarcoma and Ewing sarcoma which mainly affect adoles
Externí odkaz:
https://doaj.org/article/03b38a9800d24415a83a470902a27fe5
Autor:
Matthew W. Fittall, William Mifsud, Nischalan Pillay, Hongtao Ye, Anna-Christina Strobl, Annelien Verfaillie, Jonas Demeulemeester, Lei Zhang, Fitim Berisha, Maxime Tarabichi, Matthew D. Young, Elena Miranda, Patrick S. Tarpey, Roberto Tirabosco, Fernanda Amary, Agamemnon E. Grigoriadis, Michael R. Stratton, Peter Van Loo, Cristina R. Antonescu, Peter J. Campbell, Adrienne M. Flanagan, Sam Behjati
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-6 (2018)
FOS has been linked to bone tumour pathogenesis, and viral homologue v-fos causes osteosarcoma in mice. Here, the authors report rearrangement of FOS and its paralogue FOSB in osteoblastoma and osteoid osteoma, revealing human bone tumours that are d
Externí odkaz:
https://doaj.org/article/e874f5cac91c4dfcb8f739743873d777
Autor:
Nicholas Groth Merrild, Viktoria Holzmann, Yoanna Ariosa-Morejon, Peter A. Faull, Jennifer Coleman, William B. Barrell, Gloria Young, Roman Fischer, Daniel J. Kelly, Owen Addison, Tonia L. Vincent, Agamemnon E. Grigoriadis, Eileen Gentleman
Publikováno v:
Acta Biomaterialia. 149:179-188
Successfully replacing damaged cartilage with tissue-engineered constructs requires integration with the host tissue and could benefit from leveraging the native tissue's intrinsic healing capacity; however, efforts are limited by a poor understandin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bb5303200a1dad07847d050a9609e45
https://doi.org/10.1016/j.actbio.2022.06.032
https://doi.org/10.1016/j.actbio.2022.06.032
Autor:
Lucia Cottone, Lorena Ligammari, Hang-Mao Lee, Helen J. Knowles, Stephen Henderson, Sara Bianco, Christopher Davies, Sandra Strauss, Fernanda Amary, Ana Paula Leite, Roberto Tirabosco, Kristian Haendler, Joachim L. Schultze, Javier Herrero, Paul O’Donnell, Agamemnon E. Grigoriadis, Paolo Salomoni, Adrienne M. Flanagan
Publikováno v:
Cell death and differentiation 29(12), 2459-2471 (2022). doi:10.1038/s41418-022-01031-x
Oncohistones represent compelling evidence for a causative role of epigenetic perturbations in cancer. Giant cell tumours of bone (GCTs) are characterised by a mutated histone H3.3 as the sole genetic driver present in bone-forming osteoprogenitor ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060d9f2f6a2fa9b3ca4257b925d5abd3
https://doi.org/10.1038/s41418-022-01031-x
https://doi.org/10.1038/s41418-022-01031-x
Autor:
William B. Barrell, John N. Griffin, Jessica-Lily Harvey, HipSci Consortium, Davide Danovi, Philip Beales, Agamemnon E. Grigoriadis, Karen J. Liu, Richard Durbin, Daniel Gaffney, Chukwuma Agu, Alex Alderton, Shrada Amatya, Petr Danecek, Rachel Denton, Angela Goncalves, Reena Halai, Sarah Harper, Chris Kirton, Andrew Knights, Anja Kolb-Kokocinski, Andreas Leha, Shane McCarthy, Yasin Memari, Minal Patel, Ewan Birney, Oliver Stegle, Francesco Paolo Casale, Laura Clarke, Peter Harrison, Helena Kilpinen, Davis McCarthy, Ian Streeter, Fiona Watt, Davide Denovi, Ruta Meleckyte, Natalie Moens, Willem Ouwehand, Ludovic Vallier, Angus Lamond, Dalila Bensaddek
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Neural crest cells arise in the embryo from the neural plate border and migrate throughout the body, giving rise to many different tissue types such as bones and cartilage of the face, smooth muscles, neurons, and melanocytes. While studied extensive
Externí odkaz:
https://doaj.org/article/3dc064c4ac76449b82dd6ccf0dc8ab8c
Autor:
Chris Jones, Darren Hargrave, Safa Al-Sarraj, David W. Ellison, Rui M. Reis, Alan Ashworth, Anita E. Grigoriadis, Narinder Tamber, Marta Viana-Pereira, Diana Carvalho, Suzanne E. Little, Alan Mackay, Dorine A. Bax
Supplementary Table Legends.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f884ed26b19e6d38dd84845416e4a6a3
https://doi.org/10.1158/1078-0432.22441395.v1
https://doi.org/10.1158/1078-0432.22441395.v1
