Cobaltabis(Dicarbollide) [o-COSAN]− for Boron Neutron Capture Therapy of Head and Neck Cancer: Biodistribution and Irradiation Studies in an Experimental Oral Cancer Model

Autor: Mónica A. Palmieri, Andrea Monti Hughes, Verónica A. Trivillin, Marcela A. Garabalino, Paula S. Ramos, Silvia I. Thorp, Paula Curotto, Emiliano C. C. Pozzi, Miquel Nuez Martínez, Francesc Teixidor, Clara Viñas, Amanda E. Schwint

Publikováno v: Pharmaceuticals, Vol 17, Iss 10, p 1367 (2024)

Background: Boron neutron capture therapy (BNCT) is a tumor-selective particle radiotherapy that combines preferential boron accumulation in tumors and neutron irradiation. Based on previous studies in tumor-bearing mice, this study evaluated the bio

Externí odkaz: https://doaj.org/article/5a1d9bc41b604c8c87fb87d931f9357a

Enhancement in the Therapeutic Efficacy of In Vivo BNCT Mediated by GB-10 with Electroporation in a Model of Oral Cancer

Autor: Nahuel Olaiz, Andrea Monti Hughes, Emiliano C. C. Pozzi, Silvia Thorp, Paula Curotto, Verónica A. Trivillin, Paula S. Ramos, Mónica A. Palmieri, Guillermo Marshall, Amanda E. Schwint, Marcela A. Garabalino

Publikováno v: Cells, Vol 12, Iss 9, p 1241 (2023)

Boron neutron capture therapy (BNCT) combines preferential tumor uptake of 10B compounds and neutron irradiation. Electroporation induces an increase in the permeability of the cell membrane. We previously demonstrated the optimization of boron biodi

Externí odkaz: https://doaj.org/article/dba8cfa683ce4bf6b40a14997970601c

Therapeutic Efficacy, Radiotoxicity and Abscopal Effect of BNCT at the RA-3 Nuclear Reactor Employing Oligo-Fucoidan and Glutamine as Adjuvants in an Ectopic Colon Cancer Model in Rats

Autor: Trivillin, Debora N. Frydryk Benitez, Mónica A. Palmieri, Yanina V. Langle, Andrea Monti Hughes, Emiliano C. C. Pozzi, Silvia I. Thorp, Marcela A. Garabalino, Paula Curotto, Paula S. Ramos, María L. Paparella, Lucas Polti, Ana Eiján, Amanda E. Schwint, Verónica A.

Publikováno v: Life; Volume 13; Issue 7; Pages: 1538

Boron neutron capture therapy (BNCT) is based on the preferential uptake of 10B compounds by tumors, followed by neutron irradiation. The aim of this study was to assess, in an ectopic colon cancer model, the therapeutic efficacy, radiotoxicity, absc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::ce14f9b90728d1077e8274635ed95e62

Different oral cancer scenarios to personalize targeted therapy: Boron Neutron Capture Therapy translational studies

Autor: Andrea Monti Hughes, Amanda E. Schwint, Verónica A. Trivillin, S. Thorp, Romina F. Aromando, Maria E. Itoiz, Jessica A Goldfinger, Elisa M. Heber, P. Curotto, Emiliano Cc Pozzi, David W. Nigg, Mónica A. Palmieri, Iara S Santa Cruz, Marcela A. Garabalino, P.S. Ramos, Hanna Koivunoro

Publikováno v: Therapeutic Delivery. 10:353-362

Boron neutron capture therapy (BNCT) is a targeted therapy, which consists of preferential accumulation of boron carriers in tumor followed by neutron irradiation. Each oral cancer patient has different risks of developing one or more carcinomas and/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a43421e31abe6e49fd76c028986da551
https://doi.org/10.4155/tde-2019-0022

Clinical Veterinary Boron Neutron Capture Therapy (BNCT) Studies in Dogs with Head and Neck Cancer: Bridging the Gap between Translational and Clinical Studies

Autor: Iara S Santa Cruz, Andrea Monti Hughes, Juan Longhino, S. Nievas, Paulina Oña, Hernan Costa, Marcela A. Garabalino, Andrea Leiras, Sergio Binia, María Silvina Olivera, Emiliano C. C. Pozzi, Lucas Provenzano, Paula Alessandrini, Gustavo A. Santa Cruz, Monica Rao, Esteban Boggio, Verónica A. Trivillin, Amanda E. Schwint, Marı́a de los Angeles Cantarelli, Fabricio Brollo, Sara J. González, Romina Ventimiglia

Publikováno v: Biology
Biology, Vol 9, Iss 327, p 327 (2020)
Volume 9
Issue 10
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Translational Boron Neutron Capture Therapy (BNCT) studies performed by our group and clinical BNCT studies worldwide have shown the therapeutic efficacy of BNCT for head and neck cancer. The present BNCT studies in veterinary patients with head and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49482796614bfc70d19c63998d10bf00
https://pubmed.ncbi.nlm.nih.gov/33036386