Retrospective Analysis of the Impact of Adalimumab Initiation on Corticosteroid Utilization and Medical Costs Among Biologic-Naïve Patients with Rheumatoid Arthritis

Autor: Christina A. Spivey, Kevin L. Winthrop, Jenny Griffith, Cameron M. Kaplan, Yanru Qiao, Arnold E. Postlethwaite, Junling Wang

Publikováno v: Rheumatology and Therapy, Vol 7, Iss 1, Pp 133-147 (2019)

Abstract Introduction Treatment guidelines recommend low-dose corticosteroids as short-term therapy among rheumatoid arthritis (RA) patients. However, it may be difficult to wean/eliminate steroids once initiated. Initiation of more effective therapi

Externí odkaz: https://doaj.org/article/a2c978f04fce4818b21108fa694e83e1

Ameliorating effects of Gö6976, a pharmacological agent that inhibits protein kinase D, on collagen-induced arthritis.

Autor: Tae Won Yoon, Young-In Kim, Hongsik Cho, David D Brand, Edward F Rosloniec, Linda K Myers, Arnold E Postlethwaite, Karen A Hasty, John M Stuart, Ae-Kyung Yi

Publikováno v: PLoS ONE, Vol 14, Iss 12, p e0226145 (2019)

Toll-like receptor (TLR) signaling can contribute to the pathogenesis of arthritis. Disruption of TLR signaling at early stages of arthritis might thereby provide an opportunity to halt the disease progression and ameliorate outcomes. We previously f

Externí odkaz: https://doaj.org/article/74b836178f914fb59706a2455015e84f

COVID-19 vaccine: Call for employees in international transportation industries and international travelers as the first priority in global distribution

Autor: Zhuo Yu, Weikuan Gu, Dianjun Sun, Marcello Maida, Gang Wang, Arnold E. Postlethwaite, Barbara Zangerl, Sara W. Day, Lotfi Aleya, Yanhong Cao, Ning Xie, Jiafu Ji, Kunal Ray, Emanuel Goldman, Jingyu Chen, Monica M. Jablonski, Scott C. Howard

Publikováno v: Open Medicine, Vol 16, Iss 1, Pp 134-138 (2021)
Open Medicine
Open Medicine, De Gruyter, 2021, 16, pp.134-138. ⟨10.1515/med-2021-0210⟩

While countries are in a hurry to obtain SARS-CoV-2 vaccine, we are concerned with the availability of vaccine and whether a vaccine will be available to all in need. We predicted three possible scenarios for vaccine distributions and urge an interna

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2ea8ae5fa981052f5036bb51e0f794
https://doaj.org/article/c7c8c0b652294368b6313e8b16c002fb

Modulation by 17,20S(OH)2pD of Fibrosis-Related Mediators in Dermal Fibroblast Lines from Healthy Donors and from Patients with Systemic Sclerosis

Autor: Monica L. Brown Lobbins, Andrzej T. Slominski, Karen A. Hasty, Sicheng Zhang, Duane D. Miller, Wei Li, Tae-Kang Kim, Zorica Janjetovic, Robert C. Tuckey, Imara-Safi O. Scott, Linda K. Myers, Arnold E. Postlethwaite

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 367
International Journal of Molecular Sciences, Vol 23, Iss 367, p 367 (2022)

We previously demonstrated that the non-calcemic pregnacalciferol (pD) analog 17,20S (OH)2pD suppressed TGF-β1-induced type I collagen production in cultured normal human dermal fibroblasts. In the present studies, we examined fibroblasts cultured f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99fd26eeed67619f8059beae8322da53

Pathogenesis of systemic sclerosis

Autor: Debendra ePattanaik, Monica eBrown, Bradley C. Postlethwaite, Arnold E Postlethwaite

Publikováno v: Frontiers in Immunology, Vol 6 (2015)

SSc is one of the most complex systemic autoimmune diseases. It targets the vasculature, connective tissue producing cells (namely fibroblasts/myofibroblasts), and components of the innate and adaptive immune systems. Clinical and pathologic manifest

Externí odkaz: https://doaj.org/article/d84faf8f7fe4413aafca4d0970ec9a8a