Zobrazeno 1 - 10
of 27
pro vyhledávání: '"A E, Moormann"'
3-Methyl-4H-[1,2,4]-oxadiazol-5-one: a versatile synthon for protecting monosubstituted acetamidines
Autor:
Jeffery S. Snyder, James A. Sikorski, Michele A. Promo, Jane L. Wang, Katherine E. Palmquist, Alan E. Moormann, Mark A. Massa, Jeffrey A. Scholten, R. Keith Webber
Publikováno v:
Tetrahedron. 60:10907-10914
The utilization of 3-methyl-4H-[1,2,4]-oxadiazol-5-one as a versatile protected acetamidine is demonstrated through employment in a variety of synthetic sequences. The potassium salt ( 2a ) or the neutral form ( 2b ) is alternatively shown to be supe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21e3af81b43f1cbb052c362752de440e
https://doi.org/10.1016/j.tet.2004.09.030
https://doi.org/10.1016/j.tet.2004.09.030
Publikováno v:
Tetrahedron. 55:11787-11802
A racemic synthesis of azanoradamantane (±) -3 was accomplished via Yamamoto's MAD-catalyzed Diels-Alder protocol. Subsequently, a scalable asymmetric synthesis of azanoradamantane benzamide SC-52491 was carried out employing Helmchen's asymmetric D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73c3925ad6f7b73fe3b28524f8e6e92f
https://doi.org/10.1016/s0040-4020(99)00680-8
https://doi.org/10.1016/s0040-4020(99)00680-8
Autor:
Alan E. Moormann
Publikováno v:
Synthetic Communications. 23:789-795
Borane-pyridine complex (BAP) was found to be an excellent replacement for NaCNBH3 in the Borch reduction. Assorted aromatic, heterocyclic and aliphatic aldehydes were reacted with various substituted piperidines using standardized conditions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcd1b5c5fbeb323744ce44ad3efb01ab
https://doi.org/10.1080/00397919308009840
https://doi.org/10.1080/00397919308009840
Autor:
Ronald Keith Webber, William M. Moore, Pamela T. Manning, Sue Metz, Mihaly V. Toth, Alan E. Moormann, Gina M. Jerome, Donald W. Hansen, Christine Kornmeier, Barnett S. Pitzele
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:2651-2653
The potency and selectivity of a series of 5-hetero-2-iminohexahydroazepines were examined as inhibitors of the three human NOS isoforms. The effect of ring substitution of the 5-carbon for a heteroatom is presented. Potencies (IC50's) for these inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba9727b68b1b644f4201f4f9d03c3d37
https://doi.org/10.1016/s0960-894x(01)00523-6
https://doi.org/10.1016/s0960-894x(01)00523-6
Autor:
Alan E. Moormann
Publikováno v:
ChemInform. 24
Borane-pyridine complex (BAP) was found to be an excellent replacement for NaCNBH3 in the Borch reduction. Assorted aromatic, heterocyclic and aliphatic aldehydes were reacted with various substituted piperidines using standardized conditions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90daa21fb4605da9d69652affa216dfc
https://doi.org/10.1002/chin.199345210
https://doi.org/10.1002/chin.199345210
Autor:
Alan E. Moormann, Donald W. Hansen, Gina M. Jerome, Sue Metz, Barnett S. Pitzele, Ronald Keith Webber, William M. Moore, Mihaly V. Toth, Pamela T. Manning, Christine Kornmeier
Publikováno v:
ChemInform. 33
The potency and selectivity of a series of 5-hetero-2-iminohexahydroazepines were examined as inhibitors of the three human NOS isoforms. The effect of ring substitution of the 5-carbon for a heteroatom is presented. Potencies (IC50's) for these inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b3946ff79ba2f2c48bff4fa5da1fe71
https://doi.org/10.1002/chin.200201177
https://doi.org/10.1002/chin.200201177
Autor:
Maida A. Virina, Dai-Chang Yang, Bela Goldstin, Alan E. Moormann, Daniel L. Flynn, R F Loeffler, G. W. Gullikson
Publikováno v:
Drug Development Research. 26:405-417
Zacopride is an antiemetic agent whose (S) and (R) stereoisomers demonstrate differential pharmacology at 5-HT3 receptors, emphasizing the importance of pharmacologic profiling of each enantiomer of a racemic drug mixture. Characterization of the gas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a063b29be2951d8486f7347ac9650e2c
https://doi.org/10.1002/ddr.430260404
https://doi.org/10.1002/ddr.430260404
Autor:
Barnett S. Pitzele, Stella S. Yu, R. G. Bianchi, M. Grebner, B. Rubin, Alan E. Moormann, D. Albin, Peter H. Jones, Gary W. Gullikson, E. L. Sanguinetti
Publikováno v:
Journal of Medicinal Chemistry. 33:614-626
Lofexidine, an alpha 2-agonist, has central hypotensive activity and peripheral intestinal antisecretory activity. Analogues were synthesized with increased polarity in an attempt to prevent penetration of the blood-brain barrier. The compounds were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b57cc2b09b3d7f609489f5d52a83013a
https://doi.org/10.1021/jm00164a024
https://doi.org/10.1021/jm00164a024
Autor:
Roger Nosal, Alan E. Moormann, Richard F. Loeffler, Daniel L. Flynn, Gary W. Gullikson, Clara I. Villamil, Daniel P. Becker, Chafiq Moummi, Dai-C Yang
Publikováno v:
Journal of medicinal chemistry. 49(3)
A series of pyrrolizidine esters, amides, and ureas was prepared and tested for 5-HT(4) and 5-HT(3) receptor binding, 5-HT(4) receptor agonism in the rat tunica muscularis mucosae (TMM) assay, and for 5-HT(3) receptor-mediated functional antagonism i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96245f0a4c5942c7ba475cf5b51ceebe
https://pubmed.ncbi.nlm.nih.gov/16451077
https://pubmed.ncbi.nlm.nih.gov/16451077
Autor:
D L, Flynn, D P, Becker, V M, Dilworth, M K, Highkin, P J, Hippenmeyer, K A, Houseman, L M, Levine, M, Li, A E, Moormann, A, Rankin, M V, Toth, C I, Villamil, A J, Wittwer, B C, Holwerda
Publikováno v:
Drug design and discovery. 15(1)
The herpesvirus protease is a recently identified enzyme which is essential for viral replication. It is found in all herpesviruses and offers a new molecular target for therapeutic intervention. Its genomic structure has recently been described and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::99afaa01994c62de57d966d4fc6eb286
https://pubmed.ncbi.nlm.nih.gov/9332827
https://pubmed.ncbi.nlm.nih.gov/9332827