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Akademický článek

Smooth muscle dysfunction in the pre-inflammation site in stenotic Crohn’s-like colitis: implication of mechanical stress in bowel dysfunction in gut inflammation

Autor: John C. Johnson, Ramasatyaveni Geesala, Ke Zhang, You-Min Lin, Amosy E. M’Koma, Xuan-Zheng Shi

Publikováno v: Frontiers in Physiology, Vol 14 (2023)

Background and Aims: Gut smooth muscle dysfunctions contribute to symptoms such as abdominal cramping, diarrhea, and constipation in inflammatory bowel disease (IBD). The mechanisms for muscle dysfunctions are incompletely understood. We tested the h

Externí odkaz: https://doaj.org/article/e869c4694c464c9f8b84273de13aa321

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Akademický článek

Inflammatory Bowel Disease-Associated Colorectal Cancer: Translational and Transformational Risks Posed by Exogenous Free Hemoglobin Alpha Chain, a By-Product of Extravasated Erythrocyte Macrophage Erythrophagocytosis

Autor: Maya A. Bragg, Williams A. Breaux, Amosy E. M’Koma

Publikováno v: Medicina, Vol 59, Iss 7, p 1254 (2023)

Colonic inflammatory bowel disease (IBD) encompasses ulcerative colitis (UC) and Crohn’s colitis (CC). Patients with IBD are at increased risk for colitis-associated colorectal cancer (CACRC) compared to the general population. CACRC is preceded by

Externí odkaz: https://doaj.org/article/cf68617dd1394c64b8c7b26a2dcdd4eb

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Akademický článek

Linking bacterial enterotoxins and alpha defensin 5 expansion in the Crohn's colitis: A new insight into the etiopathogenetic and differentiation triggers driving colonic inflammatory bowel disease.

Publikováno v: PLoS ONE, Vol 16, Iss 3, p e0246393 (2021)

Evidence link bacterial enterotoxins to apparent crypt-cell like cells (CCLCs), and Alpha Defensin 5 (DEFA5) expansion in the colonic mucosa of Crohn's colitis disease (CC) patients. These areas of ectopic ileal metaplasia, positive for Paneth cell (

Externí odkaz: https://doaj.org/article/030b11b00a114d88968c225591f8ba7c

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Akademický článek

Characterization of Serum Cytokine Profile in Predominantly Colonic Inflammatory Bowel Disease to Delineate Ulcerative and Crohn’s Colitides

Autor: Olga Y. Korolkova, Jeremy N. Myers, Samuel T. Pellom, Li Wang, Amosy E. M’Koma

Publikováno v: Clinical Medicine Insights: Gastroenterology, Vol 2015, Iss 8, Pp 29-44 (2015)

Externí odkaz: https://doaj.org/article/8655eafb47054d039f2fb7eb10fe5348

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Akademický článek

Adaptive Returns of Deficient Systemic Plasma Immunoglobulin G Levels as Rehabilitation Biomarker After Emergency Colectomy for Fulminant Ulcerative Colitis

Autor: Alexander T Hawkins, Jun W Um, Amosy E M’Koma

Publikováno v: Clinical Medicine Insights: Gastroenterology, Vol 10 (2017)

Restorative proctocolectomy (RPC) with ileal pouch-anal anastomosis (IPAA) is the standard surgical treatment for ulcerative colitis (UC). Emergency colectomies are performed for fulminant colitis (ie, toxic megacolon, profuse bleeding, perforation,

Externí odkaz: https://doaj.org/article/71b733024a9e463c90869ec3b3facb6e

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Akademický článek

Correction: Human alpha defensin 5 is a candidate biomarker to delineate inflammatory bowel disease.

Autor: Amanda D Williams, Olga Y Korolkova, Amos M Sakwe, Timothy M Geiger, Samuel D James, Roberta L Muldoon, Alan J Herline, J Shawn Goodwin, Michael G Izban, Mary K Washington, Duane T Smoot, Billy R Ballard, Maria Gazouli, Amosy E M'Koma

Publikováno v: PLoS ONE, Vol 12, Iss 12, p e0189551 (2017)

[This corrects the article DOI: 10.1371/journal.pone.0179710.].

Externí odkaz: https://doaj.org/article/e84ab487be994b6abaa70206b2cc2668

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Akademický článek

Human alpha defensin 5 is a candidate biomarker to delineate inflammatory bowel disease.

Publikováno v: PLoS ONE, Vol 12, Iss 8, p e0179710 (2017)

Inability to distinguish Crohn's colitis from ulcerative colitis leads to the diagnosis of indeterminate colitis. This greatly effects medical and surgical care of the patient because treatments for the two diseases vary. Approximately 30 percent of

Externí odkaz: https://doaj.org/article/d30c102731ee4a4183ed9e64ae1967ca

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Akademický článek

Inflammatory Bowel Disease: An Expanding Global Health Problem

Autor: Amosy E. M’Koma

Publikováno v: Clinical Medicine Insights: Gastroenterology, Vol 2013, Iss 6, Pp 33-47 (2013)

Externí odkaz: https://doaj.org/article/ad791de9c758420eaaf2acf871153cff

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Linking bacterial enterotoxins and alpha defensin 5 expansion in the Crohn's colitis: A new insight into the etiopathogenetic and differentiation triggers driving colonic inflammatory bowel disease

Publikováno v: PLoS ONE, Vol 16, Iss 3, p e0246393 (2021)
PLoS ONE

Evidence link bacterial enterotoxins to apparent crypt-cell like cells (CCLCs), and Alpha Defensin 5 (DEFA5) expansion in the colonic mucosa of Crohn’s colitis disease (CC) patients. These areas of ectopic ileal metaplasia, positive for Paneth cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ace726ccbfe79726c7e7cb260ebbde
https://doaj.org/article/030b11b00a114d88968c225591f8ba7c

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Adenocarcinoma at the Ileostomy Site After a Proctocolectomy for Ulcerative Colitis and/or Familial Adenomatous Polyposis: An Overview

Autor: Alexander T. Hawkins, Amosy E. M'Koma, Samuel D. James

Publikováno v: Ostomy Wound Management. 64:30-40

Adenocarcinoma that occurs at the ileostomy site after proctocolectomy (TPC) with an end ileostomy for ulcerative colitis (UC) and/or familial adenomatous polyposis (FAP) is a late and uncommon complication. To ascertain the rate of adenocarcinoma at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f837553d7ca8f798db34c356b1ce9e9
https://doi.org/10.25270/owm.2018.6.3040

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