First administration of the Fc-attenuated anti-β amyloid antibody GSK933776 to patients with mild Alzheimer's disease: a randomized, placebo-controlled study.

Autor: Niels Andreasen, Monica Simeoni, Henrik Ostlund, Pia I Lisjo, Tormod Fladby, Amy E Loercher, Gerard J Byrne, Frances Murray, Paul T Scott-Stevens, Anders Wallin, Yinghua Y Zhang, Lena H Bronge, Henrik Zetterberg, Agneta K Nordberg, Astrid J Yeo, Shahid A Khan, Jan Hilpert, Prafull C Mistry

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0098153 (2015)

To assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of the Fc-inactivated anti-β amyloid (Aβ) monoclonal antibody (mAb) GSK933776 in patients with mild Alzheimer's disease (AD) or mild cognitive impairment (MCI).This was a tw

Externí odkaz: https://doaj.org/article/69a0e82640104afeae09379b631cf854

Molecular genetics of uveal melanoma

Autor: Amy E. Loercher, J. William Harbour

Publikováno v: Current Eye Research. 27:69-74

In the past decade, there have been impressive advances in our understanding of chromosomal, genetic and molecular alterations that occur in uveal melanoma. Nevertheless, a coherent picture of the molecular pathogenesis of this eye cancer is yet to e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11ef5fb6318e8ee65ff506fcaebb16ea
https://doi.org/10.1076/ceyr.27.2.69.15952

The role of cytokines in both the normal and malignant ovary

Autor: Amy E. Loercher, Micheal A. Nash, Ralph S. Freedman, M Gordinier, Gabriella Ferrandina

Publikováno v: Endocrine-related cancer. 6(1)

Normal ovarian tissue is rich in cytokines. Cytokines and chemokines are important in the physiology of ovarian function and of ovulation. Cytokines and chemokines may recruit cytokine-producing lymphocytes to the site of a developing follicle, and c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec2062e98d839846ddceb2de2c8a841
https://pubmed.ncbi.nlm.nih.gov/10732792

Identification of an IL-10-producing HLA-DR-negative monocyte subset in the malignant ascites of patients with ovarian carcinoma that inhibits cytokine protein expression and proliferation of autologous T cells

Autor: A E, Loercher, M A, Nash, J J, Kavanagh, C D, Platsoucas, R S, Freedman

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 163(11)

A newly described subset of monocytes has been identified in peritoneal exudate cells (PEC) from the malignant ascites from patients with ovarian cancer. These cells were characterized by the production of IL-10 and TGF-beta2, but not IL-12, IL-1alph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2aab7870728b2c14eade45a78353ccfc
https://pubmed.ncbi.nlm.nih.gov/10570318

Assessing genetic diversity patterns at neutral and adaptive loci to inform population reinforcement of an endangered migratory vulture.

Autor: Bounas, Anastasios^1,2 (AUTHOR) abounas@uoi.gr, Saravia-Mullin, Victoria² (AUTHOR), Méndez, Maria^3,4,5 (AUTHOR), Arkumarev, Volen⁶ (AUTHOR), Aghajanyan, Lusine⁷ (AUTHOR), Ararat, Korsh⁸ (AUTHOR), Buechley, Evan⁹ (AUTHOR), Dobrev, Vladimir⁶ (AUTHOR), Dobrev, Dobromir⁶ (AUTHOR), Efrat, Ron¹⁰ (AUTHOR), Klisurov, Ivaylo¹¹ (AUTHOR), Kret, Elzbieta¹² (AUTHOR), Skartsi, Theodora¹² (AUTHOR), Oppel, Steffen¹³ (AUTHOR), Petrov, Rusko¹¹ (AUTHOR), Şekercioğlu, Çağan H.^14,15,16 (AUTHOR), Vaidl, Anton¹⁷ (AUTHOR), Donázar, José A.³ (AUTHOR), Nikolov, Stoyan C.⁶ (AUTHOR), Sotiropoulos, Konstantinos¹ (AUTHOR)

Publikováno v: Journal of Ornithology. Jul2023, Vol. 164 Issue 3, p677-688. 12p.