Zobrazeno 1 - 10
of 178
pro vyhledávání: '"A E, Lew"'
Autor:
Thomas E. Lew, John F. Seymour
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-27 (2022)
Abstract BH3-mimetics are a novel drug class of small molecule inhibitors of BCL2 family proteins which restore apoptosis in malignant cells. The only currently approved BH3-mimetic, the selective BCL2 inhibitor venetoclax, is highly efficacious in c
Externí odkaz:
https://doaj.org/article/1f8c72c5c7ac4af9b178ddd3fce2ea20
Autor:
Brandon M. Murphy, Elizabeth M. Terrell, Venkat R. Chirasani, Tirzah J. Weiss, Rachel E. Lew, Andrea M. Holderbaum, Aastha Dhakal, Valentina Posada, Marie Fort, Michael S. Bodnar, Leiah M. Carey, Min Chen, Craig J. Burd, Vincenzo Coppola, Deborah K. Morrison, Sharon L. Campbell, Christin E. Burd
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The factors that determine the distinct profiles of NRAS mutants across different tumor types remain unclear. Here, the authors use an allelic series of conditional mouse models to investigate the molecular mechanisms underlying the enrichment of spe
Externí odkaz:
https://doaj.org/article/a16f75dc242345688e57e18ad40b740a
Autor:
Thomas E. Lew, Mary Ann Anderson, Victor S. Lin, Sasanka M. Handunnetti, Neil A. Came, Piers Blombery, David A. Westerman, Meaghan Wall, Constantine S. Tam, Andrew W. Roberts, John F. Seymour
Publikováno v:
Blood Advances, Vol 4, Iss 1, Pp 165-173 (2020)
Abstract: The highly selective BCL2 inhibitor venetoclax achieves deep responses in patients with relapsed or refractory (R/R) chronic lymphocytic leukemia (CLL), including undetectable minimal residual disease (uMRD). We retrospectively reviewed 62
Externí odkaz:
https://doaj.org/article/5f39def7fd624a1e988b87b4b9f93212
Autor:
Thomas E. Lew and, John F. Seymour
Publikováno v:
Precision Cancer Therapies, Volume 1 ‐ Targeting Oncogenic Drivers and Signaling Pathways in Lymphoid Malignancies. :165-185
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::781d1cba78b8fc47eaf5af202ac964b6
https://doi.org/10.1002/9781119819950.ch12
https://doi.org/10.1002/9781119819950.ch12
Publikováno v:
Journal of Rehabilitation Medicine, Vol 53, Iss 3, p jrm00163 (2021)
Objective: To evaluate existing evidence from published systematic reviews for the effectiveness of rehabilitation interventions in patients with lymphoma. Data sources: A comprehensive literature search was conducted using medical/health science dat
Externí odkaz:
https://doaj.org/article/fbbf055b9fce457dbaa340239d494310
Autor:
Thomas E Lew, Adrian Minson, Michael Dickinson, Sasanka M Handunnetti, Piers Blombery, Amit Khot, Mary Ann Anderson, David Ritchie, Constantine S Tam, John F Seymour
Publikováno v:
The Lancet Haematology. 10:e142-e154
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1882cb0c0103e43f6df60805cef6a436
https://doi.org/10.1016/s2352-3026(22)00355-6
https://doi.org/10.1016/s2352-3026(22)00355-6
Autor:
Leonardo R. Ruzzi, Pablo E. Schilman, Alvaro San Martin, Sergio E. Lew, Bruce D. Gelb, Mario R. Pagani
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Noonan syndrome and related disorders are caused by mutations in genes encoding for proteins of the RAS-ERK1/2 signaling pathway, which affect development by enhanced ERK1/2 activity. However, the mutations’ effects throughout adult life are unclea
Externí odkaz:
https://doaj.org/article/4b4df064a81d46258cecda7d84facc66
Akademický článek
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Publikováno v:
Leukemia & Lymphoma. 63:3217-3221
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df2455e34be6a099177b659abfe83099
https://doi.org/10.1080/10428194.2022.2118537
https://doi.org/10.1080/10428194.2022.2118537
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0204837 (2019)
Cooperation is one of the most studied paradigms for the understanding of social interactions. Reciprocal altruism -a special type of cooperation that is taught by means of the iterated prisoner dilemma game (iPD)- has been shown to emerge in differe
Externí odkaz:
https://doaj.org/article/699650b4446942cda124709d9bf05436