Výsledky vyhledávání - "A E, Finkbeiner"

Akademický článek

Genomic characterization and therapeutic utilization of IL-13-responsive sequences in asthma

Autor: Kyung Duk Koh, Luke R. Bonser, Walter L. Eckalbar, Ofer Yizhar-Barnea, Jiangshan Shen, Xiaoning Zeng, Kirsten L. Hargett, Dingyuan I. Sun, Lorna T. Zlock, Walter E. Finkbeiner, Nadav Ahituv, David J. Erle

Publikováno v: Cell Genomics, Vol 3, Iss 1, Pp 100229- (2023)

Summary: Epithelial responses to the cytokine interleukin-13 (IL-13) cause airway obstruction in asthma. Here we utilized multiple genomic techniques to identify IL-13-responsive regulatory elements in bronchial epithelial cells and used these data t

Externí odkaz: https://doaj.org/article/0fea5a0b0c5749adb920911ed08a0a46

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Akademický článek

Epithelial miR-141 regulates IL-13–induced airway mucus production

Autor: Sana Siddiqui, Kristina Johansson, Alex Joo, Luke R. Bonser, Kyung Duk Koh, Olivier Le Tonqueze, Samaneh Bolourchi, Rodriel A. Bautista, Lorna Zlock, Theodore L. Roth, Alexander Marson, Nirav R. Bhakta, K. Mark Ansel, Walter E. Finkbeiner, David J. Erle, Prescott G. Woodruff

Publikováno v: JCI Insight, Vol 6, Iss 5 (2021)

IL-13–induced goblet cell metaplasia contributes to airway remodeling and pathological mucus hypersecretion in asthma. miRNAs are potent modulators of cellular responses, but their role in mucus regulation is largely unexplored. We hypothesized tha

Externí odkaz: https://doaj.org/article/f7548ac36d7c4330862fdedccc59670f

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Akademický článek

Functional Profiling of CFTR-Directed Therapeutics Using Pediatric Patient-Derived Nasal Epithelial Cell Models

Autor: Jeffrey KiHyun Park, Anura Shrivastava, Chengkang Zhang, Brian A. Pollok, Walter E. Finkbeiner, Elizabeth R. Gibb, Ngoc P. Ly, Beate Illek

Publikováno v: Frontiers in Pediatrics, Vol 8 (2020)

Functional profiling of CFTR-directed therapeutics offers the potential to provide significant benefits to young people with cystic fibrosis (CF). However, the development of 2D airway epithelial cell models for individual response tests in CF childr

Externí odkaz: https://doaj.org/article/b342a898442b4dfd9091236eb20315e6

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Akademický článek

Aspiration pneumonia in the setting of diffuse esophageal retention cysts: An autopsy case report

Autor: Daffolyn Rachael Fels Elliott, Walter E. Finkbeiner, Gabrielle Rizzuto

Publikováno v: Human Pathology: Case Reports, Vol 13, Iss , Pp 53-55 (2018)

Esophageal retention cysts are rare findings at autopsy and an unusual cause of dysphagia. In the diffuse form they have been termed esophagitis cystica. We present an autopsy case of aspiration pneumonia associated with both oropharyngeal dysphagia

Externí odkaz: https://doaj.org/article/a0f5f8ea8ca74e5aa9626b0779ea6cdc

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A simple method to generate human airway epithelial organoids with externally orientated apical membranes

Autor: Carolin A. Boecking, Peter Walentek, Lorna T. Zlock, Dingyuan I. Sun, Paul J. Wolters, Hiroaki Ishikawa, Byung-Ju Jin, Peter M. Haggie, Wallace F. Marshall, Alan S. Verkman, Walter E. Finkbeiner

Publikováno v: Am J Physiol Lung Cell Mol Physiol

Organoids, which are self-organizing three-dimensional cultures, provide models that replicate specific cellular components of native tissues or facets of organ complexity. We describe a simple method to generate organoid cultures using isolated huma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64bee448a9345e6ff26971d67b8993c8
https://doi.org/10.1152/ajplung.00536.2020

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The Type 2 Asthma Mediator IL-13 Inhibits Severe Acute Respiratory Syndrome Coronavirus 2 Infection of Bronchial Epithelium

Autor: Luke R. Bonser, Walter L. Eckalbar, Lauren Rodriguez, Jiangshan Shen, Kyung Duk Koh, Khadija Ghias, Lorna T. Zlock, Stephanie Christenson, Prescott G. Woodruff, Walter E. Finkbeiner, David J. Erle

Publikováno v: American journal of respiratory cell and molecular biology, vol 66, iss 4

Asthma is associated with chronic changes in the airway epithelium, a key target of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Many epithelial changes, including goblet cell metaplasia, are driven by the type 2 cytokine IL-13, but

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b345cd95b70cf07ee1263323101d78
https://pubmed.ncbi.nlm.nih.gov/35085479

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Targeting a central feature of asthma using a cell type-selective IL-13-responsive enhancer

Autor: Nadav Ahituv, Ofer Yizhar-Barnea, Walter L. Eckalbar, Xiaoning Zeng, David J. Erle, Luke R. Bonser, Kyung Duk Koh, Lorna Zlock, Walter E. Finkbeiner, Jiangshan Shen, Dingyuan I Sun

IL-13 is a central mediator of asthma1–3. Here, we used genome-wide approaches to characterize genes and regulatory elements modulated by IL-13 and other asthma-associated cytokines in airway epithelial cells and showed how they can be used for the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63eae74b4e42c9f6e22045e045319583
https://doi.org/10.1101/2021.10.08.463596

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Akademický článek

Expansion of cultures of human tracheal epithelium with maintenance of differentiated structure and function

Autor: Jonathan H. Widdicombe, Lorne A. Sachs, Joby L. Morrow, Walter E. Finkbeiner

Publikováno v: BioTechniques, Vol 39, Iss 2, Pp 249-255 (2005)

We have developed a technique for expanding primary cultures of human tracheal epithelium while minimizing loss of differentiated structure and function. Cells were seeded at 2 × 104 cells/cm2 into T75 flasks and trypsinized when approximately 80% c

Externí odkaz: https://doaj.org/article/7cec3ffd174e49748d01a0f0a57ab1cc

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