Hypoxia-induced activation of NDR2 underlies brain metastases from Non-Small Cell Lung Cancer

Autor: Jérôme Levallet, Tiphaine Biojout, Céline Bazille, Manon Douyère, Fatéméh Dubois, Dimitri Leite Ferreira, Jasmine Taylor, Sylvain Teulier, Jérôme Toutain, Nicolas Elie, Myriam Bernaudin, Samuel Valable, Emmanuel Bergot, Guénaëlle Levallet

Publikováno v: Cell Death and Disease, Vol 14, Iss 12, Pp 1-13 (2023)

Abstract The molecular mechanisms induced by hypoxia are misunderstood in non-small cell lung cancer (NSCLC), and above all the hypoxia and RASSF1A/Hippo signaling relationship. We confirmed that human NSCLC (n = 45) as their brain metastases (BM) co

Externí odkaz: https://doaj.org/article/314a3a44fb5749b79b75d1af5f9ad218

NRP1 inhibition modulates radiosensitivity of medulloblastoma by targeting cancer stem cells

Autor: Manon Douyère, Caifeng Gong, Mylène Richard, Nadia Pellegrini-Moïse, Joël Daouk, Julien Pierson, Pascal Chastagner, Cédric Boura

Publikováno v: Cancer Cell International, Vol 22, Iss 1, Pp 1-14 (2022)

Abstract Background Medulloblastoma (MB) is the most common pediatric malignant brain tumor. Despite current therapies, the morbidity and recurrent risk remains significant. Neuropilin-1 receptor (NRP1) has been implicated in the tumor progression of

Externí odkaz: https://doaj.org/article/857627dcf9454b46b41d1d1aa89c0a18

Cross-linked poly(4‐vinylpyridine) particles for pH- and ionic strength-responsive “on–off” Pickering emulsions

Autor: Douyère, Grégory, Leclercq, Loïc, Nardello-Rataj, Véronique

Publikováno v: In Colloids and Surfaces A: Physicochemical and Engineering Aspects 20 December 2021 631

Neuropilin-1: A Key Protein to Consider in the Progression of Pediatric Brain Tumors

Autor: Manon Douyère, Pascal Chastagner, Cédric Boura

Publikováno v: Frontiers in Oncology, Vol 11 (2021)

Neuropilins are transmembrane glycoproteins that play important roles in cardiovascular and neuronal development, as well as in immunological system regulations. NRP1 functions as a co-receptor, binding numerous ligands, such as SEMA 3 or VEGF and, b

Externí odkaz: https://doaj.org/article/b02fe284b9a446c0a498c64f276cfc47

From polyethyleneimine hydrogels to Pickering-like smart 'On/Off' emulgels switched by pH and temperature

Autor: Grégory Douyère, Loïc Leclercq, Véronique Nardello-Rataj

Publikováno v: Journal of Colloid and Interface Science
Journal of Colloid and Interface Science, 2022, Journal of Colloid and Interface Science, 628, pp.807-819. ⟨10.1016/j.jcis.2022.07.177⟩

International audience; Hypothesis: According to the so-called colloidal tectonic concept, we assumed that a single self-complementary polymer-based tecton could be used to design self-assembled emulsions. The polymer must be of high-molecular weight

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16a22e5536185d41381269308b155e4b
https://doi.org/10.1016/j.jcis.2022.07.177