The presence of plasmenyl ether lipids in Capsaspora owczarzaki suggests a premetazoan origin of plasmalogen biosynthesis in animals

Autor: Joaquín Costa, Matías Gabrielli, Silvia G. Altabe, Antonio D. Uttaro

Publikováno v: Heliyon, Vol 10, Iss 12, Pp e32807- (2024)

Plasmalogens are glycerophospholipids with a vinyl ether bond, rather than an ester bond, at sn-1 position. These lipids were described in anaerobic bacteria, myxobacteria, animals and some protists, but not in plants or fungi. Anaerobic and aerobic

Externí odkaz: https://doaj.org/article/46bd68dc572f4b4097902deb1eeedcf9

Structural determinant of functionality in acyl lipid desaturases

Autor: Diego E. Sastre, Emilio Saita, Antonio D. Uttaro, Diego de Mendoza, Silvia G. Altabe

Publikováno v: Journal of Lipid Research, Vol 59, Iss 10, Pp 1871-1879 (2018)

Little is known about the structure-function relationship of membrane-bound lipid desaturases. Using a domain-swapping strategy, we found that the N terminus (comprising the two first transmembrane segments) region of Bacillus cereus DesA desaturase

Externí odkaz: https://doaj.org/article/36e970e74e5743b9a8ea0cbf7a3c175c

Sterol metabolism in the filasterean Capsaspora owczarzaki has features that resemble both fungi and animals

Autor: Sebastián R. Najle, María Celeste Molina, Iñaki Ruiz-Trillo, Antonio D. Uttaro

Publikováno v: Open Biology, Vol 6, Iss 7 (2016)

Sterols are essential for several physiological processes in most eukaryotes. Sterols regulate membrane homeostasis and participate in different signalling pathways not only as precursors of steroid hormones and vitamins, but also through its role in

Externí odkaz: https://doaj.org/article/4b281bf844ed49fba5be754ee5144528

A novel Tetrahymena thermophila sterol C-22 desaturase belongs to the fatty acid hydroxylase/desaturase superfamily

Autor: María L. Sanchez Granel, Nicolás G. Siburu, Annamária Fricska, Lucas L. Maldonado, Laura B. Gargiulo, Clara B. Nudel, Antonio D. Uttaro, Alejandro D. Nusblat

Publikováno v: Journal of Biological Chemistry. 298:102397

Sterols in eukaryotic cells play important roles in modulating membrane fluidity and in cell signaling and trafficking. During evolution, a combination of gene losses and acquisitions gave rise to an extraordinary diversity of sterols in different or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b052a1438e17e217f797fb0a0c9d8f0b
https://doi.org/10.1016/j.jbc.2022.102397

Genome-wide Transcriptional Analysis of Tetrahymena thermophila Response to Exogenous Cholesterol

Autor: Nicolás García Siburu, Claudio H. Slamovits, Alejandro D. Nusblat, Sebastián R. Najle, Eduard Ocaña-Pallarès, Clara B. Nudel, Antonio D. Uttaro, Josefina Hernández

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Digital.CSIC. Repositorio Institucional del CSIC
instname

The ciliate Tetrahymena thermophila does not require sterols for growth and synthesizes pentacyclic triterpenoid alcohols, mainly tetrahymanol, as sterol surrogates. However, when sterols are present in the environment, T. thermophila efficiently inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d8324ffbc4cfced1ad2d115ae8235e
https://pubmed.ncbi.nlm.nih.gov/31705733