Výsledky vyhledávání - "A D Bastiaan Vliegenthart"

Akademický článek

Polymerase-free measurement of microRNA-122 with single base specificity using single molecule arrays: Detection of drug-induced liver injury.

Autor: David M Rissin, Barbara López-Longarela, Salvatore Pernagallo, Hugh Ilyine, A D Bastiaan Vliegenthart, James W Dear, Juan J Díaz-Mochón, David C Duffy

Publikováno v: PLoS ONE, Vol 12, Iss 7, p e0179669 (2017)

We have developed a single probe method for detecting microRNA from human serum using single molecule arrays, with sequence specificity down to a single base, and without the use of amplification by polymerases. An abasic peptide nucleic acid (PNA) p

Externí odkaz: https://doaj.org/article/06f0f8682210475f9dba71838795e9f1

Zobrazit plný text záznamu

Akademický článek

Circulating argonaute-bound microRNA-126 reports vascular dysfunction and treatment response in acute and chronic kidney disease

Autor: Kathleen M. Scullion, A. D. Bastiaan Vliegenthart, Laura Rivoli, Wilna Oosthuyzen, Tariq E. Farrah, Alicja Czopek, David J. Webb, Robert W. Hunter, Matthew A. Bailey, Neeraj Dhaun, James W. Dear

Publikováno v: iScience, Vol 24, Iss 1, Pp 101937- (2021)

Summary: Vascular and kidney dysfunction commonly co-exist. There is a need for biomarkers of vascular health. Circulating microRNAs are biomarkers; miR-126 is endothelial cell-enriched. We measured circulating miR-126 in rats with nephrotoxic nephri

Externí odkaz: https://doaj.org/article/be8bdfd2958a4679a313fe5958f85e1c

Zobrazit plný text záznamu

Circulating argonaute-bound microRNA-126 reports vascular dysfunction and treatment response in acute and chronic kidney disease

Autor: James W. Dear, Laura Rivoli, Alicja Czopek, David J. Webb, A. D. Bastiaan Vliegenthart, Tariq E. Farrah, Matthew A. Bailey, Kathleen M. Scullion, Neeraj Dhaun, Wilna Oosthuyzen, Robert W. Hunter

Publikováno v: Scullion, K, Vliegenthart, A D B, Rivoli, L, Oosthuyzen, W, Farrah, T, Czopek, A, Webb, D J, Hunter, R W, Bailey, M A & Dhaun, N 2021, ' Circulating argonaute-bound microRNA-126 reports vascular dysfunction and treatment response in acute and chronic kidney disease ', iScience . https://doi.org/10.1016/j.isci.2020.101937
iScience, Vol 24, Iss 1, Pp 101937-(2021)
iScience

Summary Vascular and kidney dysfunction commonly co-exist. There is a need for biomarkers of vascular health. Circulating microRNAs are biomarkers; miR-126 is endothelial cell-enriched. We measured circulating miR-126 in rats with nephrotoxic nephrit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c2a6a3a533a9a90e80ac9566ab895f8
https://doi.org/10.1016/j.isci.2020.101937

Zobrazit plný text záznamu

The effect of renal dysfunction and haemodialysis on circulating liver specific miR-122

Autor: Peter J. Gallacher, James W. Dear, A. D. Bastiaan Vliegenthart, Tariq E. Farrah, Neeraj Dhaun, Carmelita M. J. de Potter, Job J. M. H. van Bragt, Laura Rivoli, Nikolaos Tzoumas

Publikováno v: British Journal of Clinical Pharmacology. 83:584-592

Aim microRNA-122 (miR-122) is a hepatotoxicity biomarker with utility in the management of paracetamol overdose and in drug development. Renal dysfunction and haemodialysis have been associated with a reduction in circulating microRNA. The objective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4b51d4784128a18f074cb762a103b4ea
https://doi.org/10.1111/bcp.13136

Zobrazit plný text záznamu

Resolution of Hypoglycemia and Cardiovascular Dysfunction After Rituximab Treatment of Insulin Autoimmune Syndrome

Autor: Anna R. Dover, James W. Dear, Catriona Clarke, Marcus J. Lyall, Robert K. Semple, A. D. Bastiaan Vliegenthart, David Church, Neeraj Dhaun, Robert W. Hunter

Publikováno v: Church, D, Hunter, R W, Lyall, M, Clarke, C, Vliegenthart, A D B, Dear, J W, Semple, R, Dhaun, N & Dover, A R 2017, ' Resolution of hypoglycemia and cardiovascular dysfunction after rituximab treatment of insulin autoimmune syndrome ', Diabetes Care . https://doi.org/10.2337/dc17-0264

D.C. is funded by a Diabetes Research & Wellness Foundation Sutherland-Earl Clinical Fellowship (RG68554). R.W.H. is supported by the Wellcome Trust–University of Edinburgh Institutional Strategic Support Fund. N.D. is supported by a British Heart

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25e068fcb77b5c404a88234e1f27ef00
https://pubmed.ncbi.nlm.nih.gov/28461453

Zobrazit plný text záznamu

Polymerase-free measurement of microRNA-122 with single base specificity using single molecule arrays: Detection of drug-induced liver injury

Autor: Salvatore Pernagallo, David M. Rissin, Hugh Ilyine, James W. Dear, David C. Duffy, A. D. Bastiaan Vliegenthart, Barbara López-Longarela, Juan J. Díaz-Mochón

Publikováno v: PLoS ONE, Vol 12, Iss 7, p e0179669 (2017)
Rissin, D M, López-Longarela, B, Pernagallo, S, Ilyine, H, Vliegenthart, B, Dear, J, Díaz-Mochón, J J & Duffy, D C 2017, ' Polymerase-free measurement of microRNA-122 with single base specificity using single molecule arrays: Detection of drug-induced liver injury ', PLoS ONE . https://doi.org/10.1371/journal.pone.0179669
Digibug. Repositorio Institucional de la Universidad de Granada
instname
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a3fae1820f06172b49aae78c75e6536
http://europepmc.org/articles/PMC5497960?pdf=render

Zobrazit plný text záznamu

Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial

Autor: Euan A Sandilands, A. D. Bastiaan Vliegenthart, D. Nicholas Bateman, Aravindan Veiraiah, James W. Dear, Judy Coyle, Simon H. L. Thomas, Aryelly Rodriguez, Jamie G. Cooper, Isabella Butcher, David J. Webb, Michael Eddleston, Alasdair Gray, H K Ruben Thanacoody, Steff Lewis

Publikováno v: The Lancet. 383:697-704

SummaryBackgroundParacetamol poisoning is common worldwide. It is treated with intravenous acetylcysteine, but the standard regimen is complex and associated with frequent adverse effects related to concentration, which can cause treatment interrupti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d86db39d51ef5017e0e3d07527290440
https://doi.org/10.1016/s0140-6736(13)62062-0

Zobrazit plný text záznamu

Ethanol consumption produces a small increase in circulating miR-122 in healthy individuals

Autor: David J. Webb, James W. Dear, Noel Sharkey, A. D. Bastiaan Vliegenthart, Jame C McCrae

Publikováno v: McCrae, J C, Sharkey, N, Webb, D J, Vliegenthart, A D B & Dear, J W 2016, ' Ethanol consumption produces a small increase in circulating miR-122 in healthy individuals ', Clinical Toxicology, vol. 54, no. 1, pp. 53-5 . https://doi.org/10.3109/15563650.2015.1112015

INTRODUCTION: MicroRNA 122 (miR-122) is a new circulating biomarker for liver injury, which increases earlier than conventional markers in patients with acetaminophen hepatotoxicity. However, as co-ingestion of ethanol is common with drug overdose, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc2425a549cb5d7694f081e72c17b10f
https://doi.org/10.3109/15563650.2015.1112015

Zobrazit plný text záznamu

Zebrafish as model organisms for studying drug-induced liver injury

Autor: A D Bastiaan, Vliegenthart, Carl S, Tucker, Jorge, Del Pozo, James W, Dear

Publikováno v: British journal of clinical pharmacology. 78(6)

Drug-induced liver injury (DILI) is a major challenge in clinical medicine and drug development. New models are needed for predicting which potential therapeutic compounds will cause DILI in humans, and new markers and mediators of DILI still need to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d4e731ac0789b4e97f3f160a6d0453ad
https://pubmed.ncbi.nlm.nih.gov/24773296

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání