Zobrazeno 1 - 10
of 988
pro vyhledávání: '"A D Attie"'
Autor:
Sauli, Fabio
Publikováno v:
In Nuclear Inst. and Methods in Physics Research, A April 2024 1061
Autor:
Natalie M. Niemi, Lia R. Serrano, Laura K. Muehlbauer, Catherine E. Balnis, Lianjie Wei, Andrew J. Smith, Keri-Lyn Kozul, Merima Forny, Olivia M. Connor, Edrees H. Rashan, Evgenia Shishkova, Kathryn L. Schueler, Mark P. Keller, Alan D. Attie, Jonathan R. Friedman, Julia K. Pagan, Joshua J. Coon, David J. Pagliarini
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract PPTC7 is a resident mitochondrial phosphatase essential for maintaining proper mitochondrial content and function. Newborn mice lacking Pptc7 exhibit aberrant mitochondrial protein phosphorylation, suffer from a range of metabolic defects, a
Externí odkaz:
https://doaj.org/article/d6347c4096ff4f039a05ff1f1aaf0cd0
Autor:
Kelly A. Mitok, Kathryn L. Schueler, Sarah M. King, Joseph Orr, Kathleen A. Ryan, Mark P. Keller, Ronald M. Krauss, Braxton D. Mitchell, Alan R. Shuldiner, Alan D. Attie
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 12, Pp 100468- (2023)
Common noncoding variants at the human 1p13.3 locus associated with SORT1 expression are among those most strongly associated with low-density lipoprotein cholesterol (LDL-C) in human genome-wide association studies. However, validation studies in mi
Externí odkaz:
https://doaj.org/article/c1be21f245b04a43b1a714819dee4fd0
Autor:
Tara R. Price, Christopher H. Emfinger, Kathryn L. Schueler, Sarah King, Rebekah Nicholson, Tim Beck, Brian S. Yandell, Scott A. Summers, William L. Holland, Ronald M. Krauss, Mark P. Keller, Alan D. Attie
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 12, Pp 100471- (2023)
Despite great progress in understanding lipoprotein physiology, there is still much to be learned about the genetic drivers of lipoprotein abundance, composition, and function. We used ion mobility spectrometry to survey 16 plasma lipoprotein subfrac
Externí odkaz:
https://doaj.org/article/6ad83e9149c14cb19d8e30950906c97d
Autor:
Christopher H Emfinger, Lauren E Clark, Brian Yandell, Kathryn L Schueler, Shane P Simonett, Donnie S Stapleton, Kelly A Mitok, Matthew J Merrins, Mark P Keller, Alan D Attie
Publikováno v:
eLife, Vol 12 (2023)
Insufficient insulin secretion to meet metabolic demand results in diabetes. The intracellular flux of Ca2+ into β-cells triggers insulin release. Since genetics strongly influences variation in islet secretory responses, we surveyed islet Ca2+ dyna
Externí odkaz:
https://doaj.org/article/de0ff10cf88640b2b8b46a53e15528a6
Autor:
Qing Yu, Xinyue Liu, Mark P. Keller, Jose Navarrete-Perea, Tian Zhang, Sipei Fu, Laura P. Vaites, Steven R. Shuken, Ernst Schmid, Gregory R. Keele, Jiaming Li, Edward L. Huttlin, Edrees H. Rashan, Judith Simcox, Gary A. Churchill, Devin K. Schweppe, Alan D. Attie, Joao A. Paulo, Steven P. Gygi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Targeted proteomics enables robust hypothesis-driven research. Here, Yu et al. present a multiplexed approach for targeted pathway proteomics and apply it to quantify protein families across 480 fully genotyped Diversity Outbred mice, revealing impac
Externí odkaz:
https://doaj.org/article/cd1a101b49ee4dfbb34edecc65790389
Autor:
Tara R Price, Donnie S Stapleton, Kathryn L Schueler, Marie K Norris, Brian W Parks, Brian S Yandell, Gary A Churchill, William L Holland, Mark P Keller, Alan D Attie
Publikováno v:
PLoS Genetics, Vol 19, Iss 7, p e1010713 (2023)
We and others have previously shown that genetic association can be used to make causal connections between gene loci and small molecules measured by mass spectrometry in the bloodstream and in tissues. We identified a locus on mouse chromosome 7 whe
Externí odkaz:
https://doaj.org/article/754e612d4ef044c484fffca47c26b6ac
Autor:
Mark P. Keller, Kelly L. Hudkins, Anath Shalev, Sushant Bhatnagar, Melkam A. Kebede, Matthew J. Merrins, Dawn Belt Davis, Charles E. Alpers, Michelle E. Kimple, Alan D. Attie
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107036- (2023)
Summary: Human and mouse genetics have delivered numerous diabetogenic loci, but it is mainly through the use of animal models that the pathophysiological basis for their contribution to diabetes has been investigated. More than 20 years ago, we sere
Externí odkaz:
https://doaj.org/article/2a0d513bf5f14082a8f6d638bd1a6e49
Autor:
Eleonora de Klerk, Yini Xiao, Christopher H. Emfinger, Mark P. Keller, David I. Berrios, Valentina Loconte, Axel A. Ekman, Kate L. White, Rebecca L. Cardone, Richard G. Kibbey, Alan D. Attie, Matthias Hebrok
Publikováno v:
JCI Insight, Vol 8, Iss 11 (2023)
Insulin secretion from pancreatic β cells is essential to the maintenance of glucose homeostasis. Defects in this process result in diabetes. Identifying genetic regulators that impair insulin secretion is crucial for the identification of novel the
Externí odkaz:
https://doaj.org/article/b4b5dbeb38934b90baccd9d13f8ca114
Autor:
Karthickeyan Chella Krishnan, Elie-Julien El Hachem, Mark P Keller, Sanjeet G Patel, Luke Carroll, Alexis Diaz Vegas, Isabela Gerdes Gyuricza, Christine Light, Yang Cao, Calvin Pan, Karolina Elżbieta Kaczor-Urbanowicz, Varun Shravah, Diana Anum, Matteo Pellegrini, Chi Fung Lee, Marcus M Seldin, Nadia A Rosenthal, Gary A Churchill, Alan D Attie, Benjamin Parker, David E James, Aldons J Lusis
Publikováno v:
eLife, Vol 12 (2023)
Mitochondria play an important role in both normal heart function and disease etiology. We report analysis of common genetic variations contributing to mitochondrial and heart functions using an integrative proteomics approach in a panel of inbred mo
Externí odkaz:
https://doaj.org/article/2a1b6fe7048b41d5bd20badbfb9d149f