Zobrazeno 1 - 10
of 531
pro vyhledávání: '"A D, Sharrocks"'
Autor:
Maram Hilwi, Katherina Shulman, Inna Naroditsky, Sari Feld, Miriam Gross-Cohen, Ilanit Boyango, Soaad Soboh, Olga Vornicova, Malik Farhoud, Preeti Singh, Gil Bar-Sela, Hadassah Goldberg, Martin Götte, Andrew D. Sharrocks, Yaoyong Li, Ralph D. Sanderson, Neta Ilan, Israel Vlodavsky
Publikováno v:
Cell Death and Disease, Vol 15, Iss 3, Pp 1-13 (2024)
Abstract Unlike the intense research effort devoted to exploring the significance of heparanase in cancer, very little attention was given to Hpa2, a close homolog of heparanase. Here, we explored the role of Hpa2 in breast cancer. Unexpectedly, we f
Externí odkaz:
https://doaj.org/article/09ad1fee324e44e58f2c01dcb813d1a6
Publikováno v:
eLife, Vol 12 (2023)
ZMYM2 is a zinc finger transcriptional regulator that plays a key role in promoting and maintaining cell identity. It has been implicated in several diseases such as congenital anomalies of the kidney where its activity is diminished and cancer where
Externí odkaz:
https://doaj.org/article/9d374fb6e3bc4b49aaf29f7cbe11c305
Autor:
Ibrahim Ahmed, Shen-Hsi Yang, Samuel Ogden, Wei Zhang, Yaoyong Li, The OCCAMs consortium, Andrew D Sharrocks
Publikováno v:
eLife, Vol 12 (2023)
Cancer is driven by both genetic and epigenetic changes that impact on gene expression profiles and the resulting tumourigenic phenotype. Enhancers are transcriptional regulatory elements that are key to our understanding of how this rewiring of gene
Externí odkaz:
https://doaj.org/article/7d4974e925854dd39070a622ae326f4c
Autor:
Dave T. Gerrard, Andrew A. Berry, Rachel E. Jennings, Matthew J. Birket, Peyman Zarrineh, Myles G. Garstang, Sarah L. Withey, Patrick Short, Sandra Jiménez-Gancedo, Panos N. Firbas, Ian Donaldson, Andrew D. Sharrocks, Karen Piper Hanley, Matthew E. Hurles, José Luis Gomez-Skarmeta, Nicoletta Bobola, Neil A. Hanley
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
How the epigenomic landscape linked to transcription regulates human embryonic development is unclear. Here, the authors analyse the dynamics of H3K27Ac, H3K4me3 and H3K27me3 during the period when organs first assemble as a platform for understandin
Externí odkaz:
https://doaj.org/article/a296a0ec6d0e434aa7dff480689080a7
Publikováno v:
F1000Research, Vol 10 (2021)
Many biological studies of transcriptional control mechanisms produce lists of genes and non-coding genomic intervals from corresponding gene expression and epigenomic assays. In higher organisms, such as eukaryotes, genes may be regulated by distal
Externí odkaz:
https://doaj.org/article/ca50e2425dbc43789366f412e4e6f37b
Publikováno v:
F1000Research, Vol 10 (2021)
Many biological studies of transcriptional control mechanisms produce lists of genes and non-coding genomic intervals from corresponding gene expression and epigenomic assays. In higher organisms, such as eukaryotes, genes may be regulated by distal
Externí odkaz:
https://doaj.org/article/a25a1322d0824903aba5ce401a6635b4
Publikováno v:
STAR Protocols, Vol 1, Iss 3, Pp 100187- (2020)
Summary: Mapping the genomic locations of chromatin-associated proteins, such as transcription factors and histone modifications, is key to understanding the mechanisms of transcriptional regulation. ChIPmentation offers a simple and robust way of in
Externí odkaz:
https://doaj.org/article/f20c116c2c044bbbb9f4606198483707
Autor:
Connor Rogerson, Samuel Ogden, Edward Britton, The OCCAMS Consortium, Yeng Ang, Andrew D Sharrocks
Publikováno v:
eLife, Vol 9 (2020)
Oesophageal adenocarcinoma (OAC) is one of the most common causes of cancer deaths. Barrett’s oesophagus (BO) is the only known precancerous precursor to OAC, but our understanding about the molecular events leading to OAC development is limited. H
Externí odkaz:
https://doaj.org/article/adeafb0268054aa3bb26cce47df94354
Autor:
Ian Prise, Andrew D. Sharrocks
Publikováno v:
Wellcome Open Research, Vol 4 (2019)
Background: The ERK MAPK pathway plays a pivotal role in regulating numerous cellular processes during normal development and in the adult but is often deregulated in disease scenarios. One of its key nuclear targets is the transcription factor ELK1,
Externí odkaz:
https://doaj.org/article/9e485af2e48a48ee8b16a283a18a2fce
Autor:
Shen-Hsi Yang, Munazah Andrabi, Rebecca Biss, Syed Murtuza Baker, Mudassar Iqbal, Andrew D. Sharrocks
Publikováno v:
Cell Reports, Vol 27, Iss 11, Pp 3215-3227.e6 (2019)
Summary: Embryonic stem cells (ESCs) must transition through a series of intermediate cell states before becoming terminally differentiated. Here, we investigated the early events in this transition by determining the changes in the open chromatin la
Externí odkaz:
https://doaj.org/article/d67f3fcb7bde45e9996c0ae97adf3f63