Zobrazeno 1 - 10
of 182
pro vyhledávání: '"A D, Sadovnick"'
Autor:
D. Sadovnick
Publikováno v:
Revue Neurologique. 175:593-596
The relative roles of genes and environment (not intra-familial environment) and interactions thereof continue to confound better understanding of the pathogenesis of multiple sclerosis (MS) and can also impact recurrence risks for family members as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85dbc7a8fed2744be0eda433c27f1013
https://doi.org/10.1016/j.neurol.2019.08.003
https://doi.org/10.1016/j.neurol.2019.08.003
Publikováno v:
Multiple sclerosis (Houndmills, Basingstoke, England). 28(3)
Objective: To evaluate the impact of temporal increase of female to male (F:M) sex ratio for persons with multiple sclerosis (MS) on the familial risk (empiric recurrence risks or RRs) for biological relatives of affected individuals. Methods: Detail
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::035c6fc1f6e138b456e3949db952b04c
https://pubmed.ncbi.nlm.nih.gov/34100315
https://pubmed.ncbi.nlm.nih.gov/34100315
Autor:
Sossi, Mariya V. Cherkasova, F. Emond, Michael Jarrett, A. J. Stoessl, Jessie Fanglu Fu, Roger Tam, D. K. B. Li, Poljanka Johnson, Anthony Traboulsee, Shawna Abel, Shannon H. Kolind, J. M. Girard, Alexander Rauscher, L. Machan, R. Vosoughi, A. D. Sadovnick
Although significant insights have been gained into the neural mechanisms of acute placebo responses, less is known about the mechanisms of longer-term placebo responses, such as those seen in clinical trials, or the interactions between these mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::649a9992f2d9a7224b1eb8a7ff8d8cb8
https://doi.org/10.1101/825638
https://doi.org/10.1101/825638
Autor:
Neda Razaz, Kerstin Hellwig, Helen Tremlett, Riley Bove, Maria K. Houtchens, Penelope Smyth, Allison McHenry, A D Sadovnick, David Rintell
Publikováno v:
Journal of Neurology. 263:1263-1273
Multiple sclerosis (MS) is a lifelong disease typically affecting individuals in young to middle adulthood. There are recognized sex differences in MS onset and clinical course. MS affects approximately three times more women than men, thus resulting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d215a2ceefae19e043dcea348af2691d
https://doi.org/10.1007/s00415-015-8005-z
https://doi.org/10.1007/s00415-015-8005-z
Autor:
Robert Cook-Deegan, Thomas O. Obisesan, Grace Ann Fasaye, T. Obisesan, E. McCarty Wood, Susie A. Sami, Lan Q. Le, Eric J. Topol, S. Hiraki, Debra L. Roter, L. Wright, Robert C. Green, Elana Cox, Eric T. Juengst, Megan S. Johnson, Norman R. Relkin, Patrick Griffith, Kristin Harkins, A D Sadovnick, Stephanie Johnson, Elana Levinson, Leo B. Waterston, Erin Linnenbringer, Pamela Sankar, Stephen G. Post, Jason Karlawish, Melissa Barber Butson, Charmaine D.M. Royal, Lisa D. Ravdin, Chen Chen, Kurt D. Christensen, Kimberly A. Quaid, Deepak L. Bhatt, Lindsay A. Farrer, Deborah Blacker, J. Scott Roberts, L. Adrienne Cupples, Peter J. Whitehouse, Jessica G. Davis, Wendy R. Uhlmann, Barbara B. Biesecker, Robert S. Stern
Publikováno v:
Alzheimer's & Dementia. 11:1222-1230
Conventional multisession genetic counseling is currently recommended when disclosing apolipoprotein E (APOE) genotype for the risk of Alzheimer's disease (AD) in cognitively normal individuals. The objective of this study was to evaluate the safety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9576ebd065e7b638e2fa27b3687ead0d
https://doi.org/10.1016/j.jalz.2014.10.014
https://doi.org/10.1016/j.jalz.2014.10.014
Autor:
David A. Dyment, Joshua D. Lee, Gavin Giovannoni, George C. Ebers, Colleen Guimond, Maria G. Criscuoli, A D Sadovnick, Vorobeychik G, Sreeram V. Ramagopalan, Heather Hanwell, I M Yee
Publikováno v:
Multiple Sclerosis Journal. 20:1182-1188
Background: There is a well-documented increase in the risk of multiple sclerosis (MS) when migrating from a region of low prevalence to one of high prevalence. Objective: We present here an investigation of MS prevalence and candidate environmental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e97c74d31c965af72319af5d191cf8d6
https://doi.org/10.1177/1352458513519179
https://doi.org/10.1177/1352458513519179
Publikováno v:
Scopus-Elsevier
Between 1972 and 1988, 145 deaths occurred among 3,126 patients attending the Multiple Sclerosis (MS) Clinics in Vancouver, British Columbia (N = 1,583), and London, Ontario (N = 1,543). We could determine the exact cause of death in 82.1% of cases (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e4d63def85117285c05672980bcdc8f
https://ora.ox.ac.uk/objects/uuid:a5a2cfa0-e717-4e9b-a10a-3ecdc565e0b8
https://ora.ox.ac.uk/objects/uuid:a5a2cfa0-e717-4e9b-a10a-3ecdc565e0b8
Publikováno v:
Scopus-Elsevier
We have evaluated genetic and environmental influences in multiple sclerosis (MS) by comparing age of onset in 99 sibling pairs concordant for the disease. We used three methods of analysis: (1) comparison of mean differences in age of onset and year
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2e157541802644219c1eef02d6ab6fb
https://doi.org/10.1093/brain/114.2.937
https://doi.org/10.1093/brain/114.2.937
Reports implicating specific transmissible agents in multiple sclerosis (MS) susceptibility continue to appear. We therefore re-evaluated MS risk in 687 step-siblings of 19 746 MS index cases. We found the risk of MS to be indistinguishable from that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2b9d43c2d28e60e9ebfb89ed09ea613
https://ora.ox.ac.uk/objects/uuid:19123126-f96c-42ae-a74f-8f41732625a4
https://ora.ox.ac.uk/objects/uuid:19123126-f96c-42ae-a74f-8f41732625a4
Background: A month-of-birth (MOB) effect has been shown in multiple sclerosis (MS). Methods: Our χ 2 analyses looked at whether this MOB effect differed by MS phenotype (“bout onset,” “primary progressive”). Results: The MOB effect was deri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30417ab92d6083b78f89b7ae3a838cdc
https://ora.ox.ac.uk/objects/uuid:6448ca3e-f205-4dc3-a3a4-2d6f8d8ac4b2
https://ora.ox.ac.uk/objects/uuid:6448ca3e-f205-4dc3-a3a4-2d6f8d8ac4b2