Zobrazeno 1 - 10
of 646
pro vyhledávání: '"A D, McCulloch"'
Publikováno v:
Molecular Metabolism, Vol 90, Iss , Pp 102058- (2024)
Objective: Exercise plays a crucial role in maintaining and improving human health. However, the precise molecular mechanisms that govern the body’s response to exercise or/compared to periods of inactivity remain elusive. Current evidence appears
Externí odkaz:
https://doaj.org/article/aabe7f77ce9d4a97b057d0c0504cdfc9
Autor:
Annabelle Fowler, Katherine R. Knaus, Stephanie Khuu, Ali Khalilimeybodi, Simon Schenk, Samuel R. Ward, Andrew C. Fry, Padmini Rangamani, Andrew D. McCulloch
Publikováno v:
Experimental Physiology, Vol 109, Iss 6, Pp 939-955 (2024)
Abstract Exercise‐induced muscle adaptations vary based on exercise modality and intensity. We constructed a signalling network model from 87 published studies of human or rodent skeletal muscle cell responses to endurance or resistance exercise in
Externí odkaz:
https://doaj.org/article/586603ec32d34a84bb57dc961d082bb0
Autor:
Jesús Lizana, Nicole D. Miranda, Sarah N. Sparrow, Peter A. G. Watson, Miriam Zachau Walker, David C. H. Wallom, Malcolm D. McCulloch
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-6 (2024)
Abstract Large ensembles of global temperature are provided for three climate scenarios: historical (2006–16), 1.5 °C and 2.0 °C above pre-industrial levels. Each scenario has 700 members (70 simulations per year for ten years) of 6-hourly mean t
Externí odkaz:
https://doaj.org/article/5a2db82378a247e1b50ca8cf6b35e042
Autor:
Sachin Govil, Brendan T. Crabb, Yu Deng, Laura Dal Toso, Esther Puyol-Antón, Kuberan Pushparajah, Sanjeet Hegde, James C. Perry, Jeffrey H. Omens, Albert Hsiao, Alistair A. Young, Andrew D. McCulloch
Publikováno v:
Journal of Cardiovascular Magnetic Resonance, Vol 25, Iss 1, Pp 1-17 (2023)
Abstract Background Cardiac shape modeling is a useful computational tool that has provided quantitative insights into the mechanisms underlying dysfunction in heart disease. The manual input and time required to make cardiac shape models, however, l
Externí odkaz:
https://doaj.org/article/7253f2fe19814843b57f4da35e842e8e
Autor:
Sachin Govil, Charlène Mauger, Sanjeet Hegde, Christopher J. Occleshaw, Xiaoyang Yu, James C. Perry, Alistair A. Young, Jeffrey H. Omens, Andrew D. McCulloch
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Current indications for pulmonary valve replacement (PVR) in repaired tetralogy of Fallot (rTOF) rely on cardiovascular magnetic resonance (CMR) image-based indices but are inconsistently applied, lead to mixed outcomes, and remain debated.
Externí odkaz:
https://doaj.org/article/5eef84314cdc4ee7bf4fd56c52eedb59
Autor:
D. McCulloch, D. E. Sergeev, N. Mayne, M. Bate, J. Manners, I. Boutle, B. Drummond, K. Kohary
Publikováno v:
Geoscientific Model Development, Vol 16, Pp 621-657 (2023)
We present results from the Met Office Unified Model (UM), a world-leading climate and weather model, adapted to simulate a dry Martian climate. We detail the adaptation of the basic parameterisations and analyse results from two simulations, one wit
Externí odkaz:
https://doaj.org/article/a075885e3e6f4564b0b0719c9e11c779
Autor:
Anna Mîra, Pablo Lamata, Kuberan Pushparajah, Georgina Abraham, Charlène A. Mauger, Andrew D. McCulloch, Jeffrey H. Omens, Malenka M. Bissell, Zach Blair, Tyler Huffaker, Animesh Tandon, Sandy Engelhardt, Sven Koehler, Thomas Pickardt, Philipp Beerbaum, Samir Sarikouch, Heiner Latus, Gerald Greil, Alistair A. Young, Tarique Hussain
Publikováno v:
Journal of Cardiovascular Magnetic Resonance, Vol 24, Iss 1, Pp 1-12 (2022)
Abstract Background Maladaptive remodelling mechanisms occur in patients with repaired tetralogy of Fallot (rToF) resulting in a cycle of metabolic and structural changes. Biventricular shape analysis may indicate mechanisms associated with adverse e
Externí odkaz:
https://doaj.org/article/46946418b9d843c8970348b2e2cee889
Publikováno v:
IET Generation, Transmission & Distribution, Vol 16, Iss 10, Pp 2049-2062 (2022)
Abstract Distributed Generators that use reactive power for voltage control in distribution networks reduce renewable curtailment but can significantly increase network losses, undermining the effectiveness of this control. This paper proposes Voltag
Externí odkaz:
https://doaj.org/article/5575904bdda041c3afcf6c70152faf1e
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Mechanosignaling describes processes by which biomechanical stimuli are transduced into cellular responses. External biophysical forces can be transmitted via structural protein networks that span from the cellular membrane to the cytoskeleton and th
Externí odkaz:
https://doaj.org/article/a8c76fad22c34a39ab8411aede7882b8
Autor:
Charlène A. Mauger, Sachin Govil, Radomir Chabiniok, Kathleen Gilbert, Sanjeet Hegde, Tarique Hussain, Andrew D. McCulloch, Christopher J. Occleshaw, Jeffrey Omens, James C. Perry, Kuberan Pushparajah, Avan Suinesiaputra, Liang Zhong, Alistair A. Young
Publikováno v:
Journal of Cardiovascular Magnetic Resonance, Vol 23, Iss 1, Pp 1-14 (2021)
Abstract Background Relationships between right ventricular (RV) and left ventricular (LV) shape and function may be useful in determining optimal timing for pulmonary valve replacement in patients with repaired tetralogy of Fallot (rTOF). However, t
Externí odkaz:
https://doaj.org/article/939fea1d2170486599fe9552534a2bd1