Zobrazeno 1 - 10
of 1 584
pro vyhledávání: '"A D, Fleming"'
Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation
Autor:
Yong Mi Choi, Dalila Ajjaji, Kaelin D. Fleming, Peter P. Borbat, Meredith L. Jenkins, Brandon E. Moeller, Shaveen Fernando, Surita R. Bhatia, Jack H. Freed, John E. Burke, Abdou Rachid Thiam, Michael V. Airola
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Lipid droplets (LDs) are dynamic organelles that contain an oil core mainly composed of triglycerides (TAG) that is surrounded by a phospholipid monolayer and LD-associated proteins called perilipins (PLINs). During LD biogenesis, perilipin
Externí odkaz:
https://doaj.org/article/88d19ef3aa294ad58ab797d027080ed5
Autor:
Sarah Asemota, Wendy Effah, Kirsten L. Young, Jeremiah Holt, Linnea Cripe, Suriyan Ponnusamy, Thirumagal Thiyagarajan, Dong-Jin Hwang, Yali He, Keely Mcnamara, Daniel Johnson, Yinan Wang, Brandy Grimes, Yekta Khosrosereshki, T.J. Hollingsworth, Martin D. Fleming, Frances E. Pritchard, Ashley Hendrix, Farhan Khan, Meiyun Fan, Liza Makowski, Zheng Yin, Hironobu Sasano, D. Neil Hayes, Lawrence M. Pfeffer, Duane D. Miller, Ramesh Narayanan
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113461- (2023)
Summary: Triple-negative breast cancer (TNBC) is an aggressive subtype with no targeted therapeutics. The luminal androgen receptor (LAR) subtype constitutes 15% of TNBC and is enriched for androgen receptor (AR) and AR target genes. Here, we show th
Externí odkaz:
https://doaj.org/article/ac241ea52bf347e5b56f2020cc95e398
Autor:
Mark D. Fleming, Nadia Safaeinili, Margae Knox, Elizabeth Hernandez, Emily E. Esteban, Urmimala Sarkar, Amanda L. Brewster
Publikováno v:
BMC Health Services Research, Vol 22, Iss 1, Pp 1-9 (2022)
Abstract Background Social needs case management programs are a strategy to coordinate social and medical care for high-risk patients. Despite widespread interest in social needs case management, not all interventions have shown effectiveness. A lack
Externí odkaz:
https://doaj.org/article/8695ce50ad06464d9d41e3624b4ca3a2
Autor:
Alexandra T. Cocca, MD, Brittany E. Levy, MD, Jennifer T. Castle, MD, Wesley S. Wilt, MD, Mark D. Fleming, MD, Alexandra E. Kejner, MD, Rony K. Aouad, MD, Samuel C. Tyagi, MD
Publikováno v:
Journal of Vascular Surgery Cases and Innovative Techniques, Vol 8, Iss 4, Pp 606-609 (2022)
Carotid blowout syndrome is a life-threatening complication for patients with head and neck cancer. Temporizing stent graft procedures improve short-term survival and can be the definitive treatment for various reasons, including a poor oncologic pro
Externí odkaz:
https://doaj.org/article/82c81652cab14a8aadee0d19edfae612
Autor:
D. Fleming, Mark1 mark.fleming@berkeley.edu
Publikováno v:
Anthropology & Medicine. Dec2023, Vol. 30 Issue 4, p330-345. 16p.
Publikováno v:
International Journal for Equity in Health, Vol 21, Iss 1, Pp 1-12 (2022)
Abstract Background Medical neutrality is a normative arrangement that differentiates a zone of medical treatment disconnected from the field of politics. While medical neutrality aims to ensure impartial healthcare for all and to shield the healthca
Externí odkaz:
https://doaj.org/article/82c94aa7e51045a0a3df263152bc36ac
Autor:
Bilge Nazli Altay, Paul D. Fleming, Md Arifur Rahman, Alexandra Pekarovicova, Bruce Myers, Cem Aydemir, Arif Karademir
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Ultraviolet/ozone (UV/O3) treatment has been reported to be an effective method to modify properties such as wettability, adhesion or adsorption of plastic surfaces. The change in the surface is measured by contact angle analysis, which empl
Externí odkaz:
https://doaj.org/article/5f1ed4a1f52a4d9aa131def15dd00154
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The essential protein kinase PDK1 is activated by phospoinositide-mediated dimerization and trans-autophosphorylation. Here, the authors show that in the absence of PIP3 or PI(3,4)P2 phosphoinositides, PDK1 is maintained in an inactive, autoinhibited
Externí odkaz:
https://doaj.org/article/12cf17b4eda64639a643128b30b79f8c
Autor:
Manoj K. Rathinaswamy, Meredith L. Jenkins, Benjamin R. Duewell, Xuxiao Zhang, Noah J. Harris, John T. Evans, Jordan T.B. Stariha, Udit Dalwadi, Kaelin D. Fleming, Harish Ranga-Prasad, Calvin K. Yip, Roger L. Williams, Scott D. Hansen, John E. Burke
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112172- (2023)
Summary: Class IB phosphoinositide 3-kinase (PI3Kγ) is activated in immune cells and can form two distinct complexes (p110γ-p84 and p110γ-p101), which are differentially activated by G protein-coupled receptors (GPCRs) and Ras. Using a combination
Externí odkaz:
https://doaj.org/article/adaec01d7c824f20bc3e5572c80805c4
Autor:
Daniel R Labuz, Giavonni Lewis, Irma D Fleming, Callie M Thompson, Yan Zhai, Matthew A Firpo, Daniel T Leung
Publikováno v:
eLife, Vol 12 (2023)
Burn injuries are a leading cause of unintentional injury, associated with a dysfunctional immune response and an increased risk of infections. Despite this, little is known about the role of T cells in human burn injury. In this study, we compared t
Externí odkaz:
https://doaj.org/article/bb21d4530b43465091764caf3fc3846b