Zobrazeno 1 - 10
of 239
pro vyhledávání: '"A D, Durnev"'
Autor:
S. V. Alekseeva, A. V. Sorokina, A. V. . Volkova, I. A. Miroshkina, K. S. Kachalov, I. V. Alekseev, A. D. Zakharov, A. D. Durnev
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 4, Pp 63-69 (2024)
Relevance. Acute toxicity testing is a common procedure for preclinical safety testing of potential agents. The purpose of this study was to study the acute toxicity of the compound GIZH-272, a new dibenzofuran oxime derivative with anti-ischemic and
Externí odkaz:
https://doaj.org/article/9f3cd64f6b014c02b599645f3bbfa364
Autor:
S. A. Kryzhanovskii, I. B. Tsorin, E. O. Ionova, V. V. Barchukov, V. N. Stolyaruk, M. B. Vititnova, L. G. Kolik, A. D. Durnev
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 3, Pp 82-93 (2023)
Background. Earlier, on the translational model of alcoholic cardiomyopathy (ACMP) developed by us in outbred white rats, which reproduces the main clinical diagnostic signs of this disease, it was shown that in rats of both sexes under conditions of
Externí odkaz:
https://doaj.org/article/0105e1608a7d4ea5a72c22416b064989
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 2, Pp 45-53 (2023)
Imbalance of glucose homeostasis in the mother-placenta-fetus system in case of gestational diabetes mellitus (GDM) leads to pre- and postnatal abnormalities in offspring. Lack of universally recognized GDM-model complicates the search for pathogenet
Externí odkaz:
https://doaj.org/article/edfdb1f009b446c0b3c3059c4d77d62b
Autor:
A. V. Sorokina, S. V. Alekseeva, I. A. Miroshkina, A. V. Volkova, K. S. Kachalov, A. D. Zakharov, I. V. Alekseev, A. D. Durnev
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 1, Pp 51-57 (2023)
Relevance. Assay of acute toxicity is a mandatory step in a preclinical safety study of medicines and pharmaceutical substances. The purpose of this study was to determine the parameters of acute toxicity of the substance GIZH-298. Methods. GIZH-298
Externí odkaz:
https://doaj.org/article/ef86978f9c8a4bdfaae7aaadec7b4c86
Autor:
A. D. Durnev
Publikováno v:
Регуляторные исследования и экспертиза лекарственных средств, Vol 13, Iss 1, Pp 8-13 (2023)
The first principle for ensuring patient safety is to do no harm (primum non nocere). It clearly justifies why the legislative requirements for the safety of medicinal products should be strict and meticulous. The aim of preclinical safety evaluation
Externí odkaz:
https://doaj.org/article/6cf602bf58c64bbe9134686b821d3370
Autor:
A. V. Sorokina, A. K. Zhanataev, Z. V. Chayka, I. A. Miroshkina, A. A. Lisitsyn, A. D. Durnev
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 4, Pp 43-49 (2023)
Relevance. Diabetes mellitus is a widespread, socially significant disease. In this regard, it is important to obtain an experimental model that precedes subsequent experiments on pharmacological screening and/or study of the mechanism of action of a
Externí odkaz:
https://doaj.org/article/14530dc5a30c4743bd511c7360f119d2
Autor:
A. D. Durnev, A. K. Zhanataev
Publikováno v:
Регуляторные исследования и экспертиза лекарственных средств, Vol 12, Iss 1, Pp 90-109 (2022)
Genotoxic lesions are not only a cause of genetic pathologies and cancer, but also the most common and significant factor of the etiopathology of cardiovascular and neurodegenerative disorders, reproductive losses, infertility, and aging. This requir
Externí odkaz:
https://doaj.org/article/e20df0c6438b4ad486716f05f92d6226
Autor:
I. A. Miroshkina, A. V. Sorokina, I. B. Tsorin, V. N. Stolyaruk, M. B. Vititnova, S. A. Kryzhanovskiy, A. D. Durnev
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 4, Pp 29-35 (2022)
The purpose of the study. Investigation of the effect of the fabomotizol dihydrochloride systematic therapy on the morphological picture of the heart left ventricle (LV) in rats in the subacute period of myocardial infarction. Materials and methods.
Externí odkaz:
https://doaj.org/article/65d03b50b2dd4332974fe79367d38a0a
Autor:
Aliy K. Zhanataev, Sergey E. Pigarev, Elena I. Fedoros, Andrey V. Panchenko, Elena A. Anisina, Zlata V. Chayka, Andrey D. Durnev, Vladimir N. Anisimov
Publikováno v:
Toxicology Reports, Vol 9, Iss , Pp 743-749 (2022)
The study investigated antigenotoxic and antimutagenic activity of novel lignin-derived polyphenolic composition (BP-C2) with ammonium molybdate towards cyclophosphamide and dioxidine in the bone marrow, blood and liver cells of BALB/c mice. BP-C2 wa
Externí odkaz:
https://doaj.org/article/3c6cf83a06824b30a6c9b6de5b00575f
Autor:
I. A. Miroshkina, L. M. Kozhevnikova, I. B. Tsorin, V. N. Stolyaruk, M. B. Vititnova, S. A. Kryzhanovskii, A. D. Durnev
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 1, Pp 30-37 (2021)
It is known that the alcoholic cardiomyopathy (ACMP) is the main reason for lethality from chronic alcoholism. For ACMP the risk of development of malignant violations of a heart rhythm which result approximately at 40% of such patients is sudden hea
Externí odkaz:
https://doaj.org/article/a6f87f8d7fc042e2a81daf443f7f900f