Zobrazeno 1 - 10
of 158
pro vyhledávání: '"A D, Bershadsky"'
Actin polymerisation and crosslinking drive left-right asymmetry in single cell and cell collectives
Autor:
Yee Han Tee, Wei Jia Goh, Xianbin Yong, Hui Ting Ong, Jinrong Hu, Ignacius Yan Yun Tay, Shidong Shi, Salma Jalal, Samuel F. H. Barnett, Pakorn Kanchanawong, Wenmao Huang, Jie Yan, Yong Ann Ben Lim, Visalatchi Thiagarajan, Alex Mogilner, Alexander D. Bershadsky
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
In this work, the authors identify regulators of actin filament assembly involved in chiral organisation of the actin cytoskeleton in single cells and chiral alignment of cells in groups. This provides insights into how actin-driven chirality underli
Externí odkaz:
https://doaj.org/article/a04bac554ea94ed8891bb4b8355d7cab
Autor:
N. O. Alieva, A. K. Efremov, S. Hu, D. Oh, Z. Chen, M. Natarajan, H. T. Ong, A. Jégou, G. Romet-Lemonne, J. T. Groves, M. P. Sheetz, J. Yan, A. D. Bershadsky
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Fiolopodia are involved in cell migration and their attachment to the ECM is mediated by integrin receptors. Here the authors show that myosin X induced filipodia adhesion to fibronectin requires activity of myosin IIA at the filopodium base and form
Externí odkaz:
https://doaj.org/article/239c9ca67f0f454d9d9ef6109dc7854c
Autor:
Bipul R. Acharya, Selwin K. Wu, Zi Zhao Lieu, Robert G. Parton, Stephan W. Grill, Alexander D. Bershadsky, Guillermo A. Gomez, Alpha S. Yap
Publikováno v:
Cell Reports, Vol 18, Iss 12, Pp 2854-2867 (2017)
Formins are a diverse class of actin regulators that influence filament dynamics and organization. Several formins have been identified at epithelial adherens junctions, but their functional impact remains incompletely understood. Here, we tested the
Externí odkaz:
https://doaj.org/article/78266f0bc89a48699a31cb4997d97b48
Publikováno v:
Biology Open, Vol 4, Iss 11, Pp 1569-1575 (2015)
The formin family proteins are important regulators of actin polymerization that are involved in many cellular processes. However, little is known about their specific cellular localizations. Here, we show that Diaphanous-related formin-3 (mDia2) loc
Externí odkaz:
https://doaj.org/article/94a33c79bfd44f22be25c38a17df8f2c
Autor:
Wenhong Li, Wen-Lu Chung, Michael M. Kozlov, Ohad Medalia, Benjamin Geiger, Alexander D. Bershadsky
Adherent filopodia are elongated finger-like membrane protrusions, extending from the edges of diverse cell types and participating in cell adhesion, spreading, migration and environmental sensing. The formation and elongation of filopodia are driven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd5bfb2343f65de0819f17aacfa65317
https://doi.org/10.1101/2022.06.09.495577
https://doi.org/10.1101/2022.06.09.495577
Autor:
Cheng-han Yu, Nisha Bte Mohd Rafiq, Anitha Krishnasamy, Kevin L. Hartman, Gareth E. Jones, Alexander D. Bershadsky, Michael P. Sheetz
Publikováno v:
Cell Reports, Vol 5, Iss 5, Pp 1456-1468 (2013)
Matrix-activated integrins can form different adhesion structures. We report that nontransformed fibroblasts develop podosome-like adhesions when spread on fluid Arg-Gly-Asp peptide (RGD)-lipid surfaces, whereas they habitually form focal adhesions o
Externí odkaz:
https://doaj.org/article/a0299df790664630a4d5626619be626f
Publikováno v:
Seminars in Cell & Developmental Biology. 102:73-80
The actomyosin cytoskeleton network plays a key role in a variety of fundamental cellular processes such as cell division, migration, and cell adhesion. The functions of cytoskeleton rely on its capability to receive, generate, respond to and transmi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce0ee0e63d0d79ddb4c4c94f58e5603
https://doi.org/10.1016/j.semcdb.2019.11.016
https://doi.org/10.1016/j.semcdb.2019.11.016
Autor:
Artem K, Efremov, Mingxi, Yao, Yuze, Sun, Yee Han, Tee, Michael P, Sheetz, Alexander D, Bershadsky, Boris, Martinac, Jie, Yan
Publikováno v:
Biomaterials. 284
Filopodia are ubiquitous membrane projections that play crucial role in guiding cell migration on rigid substrates and through extracellular matrix by utilizing yet unknown mechanosensing molecular pathways. As recent studies show that Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a6ab52231e907e0bfe8416ef5576965a
https://pubmed.ncbi.nlm.nih.gov/35395455
https://pubmed.ncbi.nlm.nih.gov/35395455
Autor:
HaiYang, Wang, Jinrong, Hu, Kexi, Yi, Zhiming, Ma, XinJie, Song, Yaelim, Lee, Petr, Kalab, Alexander D, Bershadsky, Yansong, Miao, Rong, Li
Publikováno v:
SSRN Electronic Journal.
The first asymmetric meiotic cell divisions in mouse oocytes are driven by formin 2 (FMN2)-nucleated actin polymerization around the spindle. In this study, we investigated how FMN2 is recruited to the spindle peripheral ER and how its activity is re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb332e4b8888c6a6c63c3f09a523dde3
https://doi.org/10.2139/ssrn.4075229
https://doi.org/10.2139/ssrn.4075229
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0163915 (2016)
A nodal cytoplasmic actin network underlies actin cytoplasm cohesion in the absence of stress fibers. We previously described such a network that forms upon Latrunculin A (LatA) treatment, in which formin DAAM1 was localized at these nodes. Knock dow
Externí odkaz:
https://doaj.org/article/91dae01b4b2241608efa05e1bbee3684