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The serum- and glucocorticoid-induced protein kinase-1 (Sgk-1) mitochondria connection: Identification of the IF-1 inhibitor of the F1F0-ATPase as a mitochondria-specific binding target and the stress-induced mitochondrial localization of endogenous Sgk-1

Autor: Anita C. Maiyar, Salvatore Cilia, Gary L. Firestone, Bridget A. O'Keeffe, Maria Vaysberg

Publikováno v: Biochimie. 95:1258-1265

The expression, localization and activity of the serum- and glucocorticoid- induced protein kinase, Sgk-1, are regulated by multiple hormonal and environmental cues including cellular stress. Biochemical fractionation and indirect immunofluorescence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::514487036f273242f886aa207d4ad6c6
https://doi.org/10.1016/j.biochi.2013.01.019

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The stimulus-dependent co-localization of serum- and glucocorticoid-regulated protein kinase (Sgk) and Erk/MAPK in mammary tumor cells involves the mutual interaction with the importin-alpha nuclear import protein

Autor: Meredith L. Leong, Susan Tran, Patricia Buse, Gary L. Firestone, Kim L. Failor, Anita C. Maiyar

Publikováno v: Experimental Cell Research. 313:3261-3275

In Con8 rat mammary epithelial tumor cells, indirect immunofluorescence revealed that Sgk (serum- and glucocorticoid-regulated kinase) and Erk/MAPK (extracellular signal-regulated protein kinase/mitogen activated protein kinase) co-localized to the n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::613e3414f841b0b970dc42609d5072e7
https://doi.org/10.1016/j.yexcr.2007.07.009

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Expression of the Serum- and Glucocorticoid-inducible Protein Kinase, Sgk, Is a Cell Survival Response to Multiple Types of Environmental Stress Stimuli in Mammary Epithelial Cells

Autor: Bridget A. O'Keeffe, Anita C. Maiyar, Brian Kim, Meredith L. Leong, Gary L. Firestone

Publikováno v: Journal of Biological Chemistry. 278:5871-5882

The effects of multiple stress stimuli on the cellular utilization of the serum- and glucocorticoid-inducible protein kinase (Sgk) were examined in NMuMg mammary epithelial cells exposed to hyperosmotic stress induced by the organic osmolyte sorbitol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af8467219773325d9756976325b2f15a
https://doi.org/10.1074/jbc.m211649200

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Glucocorticoid-Stimulated CCAAT/Enhancer-Binding Protein α Expression Is Required for Steroid-Induced G1 Cell Cycle Arrest of Minimal-Deviation Rat Hepatoma Cells

Autor: Ying Ge, Gary L. Firestone, Ross A. Ramos, Anita C. Maiyar, K E Simon, Y Nishio, C C Ridder

Publikováno v: Molecular and Cellular Biology. 16:5288-5301

By genetic correlation with the growth-suppressible phenotype and direct functional tests, we demonstrate that the glucocorticoid-stimulated expression of the CCAAT/enhancer-binding protein alpha (C/EBP alpha) transcription factor is required for the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c557052afd481837a5dadc8325da975
https://doi.org/10.1128/mcb.16.10.5288

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p53 Stimulates Promoter Activity of the sgk Serum/Glucocorticoid-inducible Serine/Threonine Protein Kinase Gene in Rodent Mammary Epithelial Cells

Autor: Phan T. Phu, Helen H. Cha, Arthur J Huang, Anita C. Maiyar, Gary L. Firestone

Publikováno v: Journal of Biological Chemistry. 271:12414-12422

sgk is a novel member of the serine/threonine protein kinase gene family that is transcriptionally regulated by serum and glucocorticoids in mammary epithelial cells. To functionally determine if the sgk promoter is regulated by the p53 tumor suppres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24caba6d2ed2924e320fdc8ae36bd0a6
https://doi.org/10.1074/jbc.271.21.12414

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Glucocorticoids induce a G1/G0 cell cycle arrest of Con8 rat mammary tumor cells that is synchronously reversed by steroid withdrawal or addition of transforming growth factor-alpha

Autor: Gary L. Firestone, Luis Goya, Anita C. Maiyar, Ying Ge

Publikováno v: Molecular Endocrinology. 7:1121-1132

Con8 mammary tumor cells are an epithelial cell line derived from the 7,12-dimethylbenz(alpha)anthracene-induced 13762NF rat mammary adenocarcinoma. The synthetic glucocorticoid dexamethasone suppresses the growth of Con8 cells, and after 5 days of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::771877dd6aec364d1a4a37e824af7d03
https://doi.org/10.1210/mend.7.9.8247014

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Characterization of sgk, a Novel Member of the Serine/Threonine Protein Kinase Gene Family Which Is Transcriptionally Induced by Glucocorticoids and Serum

Autor: Luis Goya, Melanie K. Webster, Ying Ge, Gary L. Firestone, Anita C. Maiyar

Publikováno v: Molecular and Cellular Biology. 13:2031-2040

A novel member of the serine/threonine protein kinase gene family, designated sgk, for serum and glucocorticoid-regulated kinase, was identified in a differential screen for glucocorticoid-inducible transcripts expressed in the Con8.hd6 rat mammary t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eb83f1ea11ca16183d24d8eb8752fe6
https://doi.org/10.1128/mcb.13.4.2031-2040.1993

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Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum

Autor: M K Webster, L Goya, Y Ge, A C Maiyar, G L Firestone

Publikováno v: Molecular and Cellular Biology. 13:2031-2040

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e15541f751afb6372bfdf5e6e80a983c
https://doi.org/10.1128/mcb.13.4.2031

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Transfaction of avian vitamin D-dependent calbindin-D28K 5' flanking promoter sequence in primary chick kidney cells

Autor: Anita C. Maiyar, Anthony W. Norman, Phillip P. Minghetti

Publikováno v: Molecular and Cellular Endocrinology. 78:127-135

Expression of the vitamin D induced calbindin-D28K protein is transcriptionally controlled by the steroid hormone 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) in a tissue-specific manner in the intestine and kidney. In order to examine the cis-acting eleme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6819e608fc1b9473fa7105a3feb8aa72
https://doi.org/10.1016/0303-7207(91)90193-v

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Importin-α Mediates the Regulated Nuclear Targeting of Serum- and Glucocorticoid-inducible Protein Kinase (Sgk) by Recognition of a Nuclear Localization Signal in the Kinase Central Domain

Autor: Meredith L. Leong, Anita C. Maiyar, Gary L. Firestone

The transcriptionally regulated serum and glucocorticoid inducible protein kinase (Sgk) is localized to the nucleus in a serum-dependent manner, and a yeast two-hybrid genetic screen uncovered a specific interaction between Sgk and the importin-alpha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b84651324be5086809b07d88cee7bfcb
https://europepmc.org/articles/PMC151592/

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