Zobrazeno 1 - 10
of 232
pro vyhledávání: '"A C Leary"'
Autor:
Derek Rodriguez, Kaira A. Church, Alicia N. Pietramale, Sandra M. Cardona, Difernando Vanegas, Colin Rorex, Micah C. Leary, Isabel A. Muzzio, Kevin R. Nash, Astrid E. Cardona
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-18 (2024)
Abstract Diabetic retinopathy (DR) affects about 200 million people worldwide, causing leakage of blood components into retinal tissues, leading to activation of microglia, the resident phagocytes of the retina, promoting neuronal and vascular damage
Externí odkaz:
https://doaj.org/article/92e45cdef9714daa8d01b50b87314d70
Autor:
Kimberly A. Jett, Zakery N. Baker, Amzad Hossain, Aren Boulet, Paul A. Cobine, Sagnika Ghosh, Philip Ng, Orhan Yilmaz, Kris Barreto, John DeCoteau, Karen Mochoruk, George N. Ioannou, Christopher Savard, Sai Yuan, Osama H.M.H. Abdalla, Christopher Lowden, Byung-Eun Kim, Hai-Ying Mary Cheng, Brendan J. Battersby, Vishal M. Gohil, Scot C. Leary
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 1 (2023)
Signaling circuits crucial to systemic physiology are widespread, yet uncovering their molecular underpinnings remains a barrier to understanding the etiology of many metabolic disorders. Here, we identified a copper-linked signaling circuit activate
Externí odkaz:
https://doaj.org/article/018c1e9c28eb4a92a02a5abcb7afd106
Autor:
Maa O. Quartey, Jennifer N. K. Nyarko, Jason M. Maley, Jocelyn R. Barnes, Maria A. C. Bolanos, Ryan M. Heistad, Kaeli J. Knudsen, Paul R. Pennington, Josef Buttigieg, Carlos E. De Carvalho, Scot C. Leary, Matthew P. Parsons, Darrell D. Mousseau
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract The pool of β-Amyloid (Aβ) length variants detected in preclinical and clinical Alzheimer disease (AD) samples suggests a diversity of roles for Aβ peptides. We examined how a naturally occurring variant, e.g. Aβ(1–38), interacts with
Externí odkaz:
https://doaj.org/article/986c73bc802940a9ae4cdf2d043e1a43
Autor:
Christopher Lowden, Aren Boulet, Nicholas A. Boehler, Shavanie Seecharran, Julian Rios Garcia, Nicholas J. Lowe, Jiashu Liu, Jonathan L.K. Ong, Wanzhang Wang, Lingfeng Ma, Arthur H. Cheng, Adriano Senatore, D. Ashley Monks, Bao-hua Liu, Scot C. Leary, Hai-Ying Mary Cheng
Publikováno v:
Cell Reports, Vol 36, Iss 11, Pp 109704- (2021)
Summary: Histone variants are crucial regulators of chromatin structure and gene transcription, yet their functions within the brain remain largely unexplored. Here, we show that the H2A histone variant H2A.Z is essential for neuronal survival. Mice
Externí odkaz:
https://doaj.org/article/9ddb9e63dbef4337b6ecf22bdd986877
Autor:
Anjuman Ara, Zhaojia Wu, Aizhang Xu, Khawaja Ashfaque Ahmed, Scot C. Leary, Md. Fahmid Islam, Rajni Chibbar, Yue Wu, Jim Xiang
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 9534 (2022)
Two common γ-chain family cytokines IL-2 and IL-15 stimulate the same mammalian target of rapamycin complex-1 (mTORC1) signaling yet induce effector T (TE) and memory T (TM) cell differentiation via a poorly understood mechanism(s). Here, we prepare
Externí odkaz:
https://doaj.org/article/36032aee1f6c479fa59488229f76618f
Publikováno v:
Hospital Pediatrics. 13:275-282
BACKGROUND AND OBJECTIVES Inequities in pediatric illness include unequal treatment and outcomes for children of historically marginalized races/ethnicities. Length of stay (LOS) is used to assess health care quality and is associated with higher cos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0b17ffdd7deb556e1f654ade20a4ee6
https://doi.org/10.1542/hpeds.2021-006471
https://doi.org/10.1542/hpeds.2021-006471
Autor:
Xinyu Zhu, Aren Boulet, Katherine M Buckley, Casey B Phillips, Micah G Gammon, Laura E Oldfather, Stanley A Moore, Scot C Leary, Paul A Cobine
Publikováno v:
eLife, Vol 10 (2021)
The mitochondrial carrier family protein SLC25A3 transports both copper and phosphate in mammals, yet in Saccharomyces cerevisiae the transport of these substrates is partitioned across two paralogs: PIC2 and MIR1. To understand the ancestral state o
Externí odkaz:
https://doaj.org/article/d7782b206ce2471e920d657626b83899
Autor:
Shivatheja Soma, Marcos N. Morgada, Mandar T. Naik, Aren Boulet, Anna A. Roesler, Nathaniel Dziuba, Alok Ghosh, Qinhong Yu, Paul A. Lindahl, James B. Ames, Scot C. Leary, Alejandro J. Vila, Vishal M. Gohil
Publikováno v:
Cell Reports, Vol 29, Iss 12, Pp 4114-4126.e5 (2019)
Summary: In eukaryotes, cellular respiration is driven by mitochondrial cytochrome c oxidase (CcO), an enzyme complex that requires copper cofactors for its catalytic activity. Insertion of copper into its catalytically active subunits, including COX
Externí odkaz:
https://doaj.org/article/6322aed5c16a4dc79ccf348a0f9dc969
Autor:
Anjuman Ara, Aizhang Xu, Khawaja Ashfaque Ahmed, Scot C. Leary, Md. Fahmid Islam, Zhaojia Wu, Rajni Chibbar, Jim Xiang
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1, p 37 (2021)
Energy sensors mTORC1 and AMPKα1 regulate T-cell metabolism and differentiation, while rapamycin (Rapa)-inhibition of mTORC1 (RIM) promotes T-cell memory. However, the underlying pathway and the role of AMPKα1 in Rapa-induced T-cell memory remain e
Externí odkaz:
https://doaj.org/article/42c618c83d734e1ea3b101a2fd9bf4b6
Autor:
Brett M. Hakey, Dylan C. Leary, Jordan C. Martinez, Jonathan M. Darmon, Novruz G. Akhmedov, Jeffrey L. Petersen, Carsten Milsmann
Publikováno v:
Organometallics. 41:2268-2280
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4408fbc90d679066d64bc0f078e207c9
https://doi.org/10.1021/acs.organomet.2c00260
https://doi.org/10.1021/acs.organomet.2c00260