Zobrazeno 1 - 10
of 980
pro vyhledávání: '"A C Hartley"'
Autor:
Jan Lj. Miljkovic, Nils Burger, Justyna M. Gawel, John F. Mulvey, Abigail A.I. Norman, Takanori Nishimura, Yoshiyuki Tsujihata, Angela Logan, Olga Sauchanka, Stuart T. Caldwell, Jordan L. Morris, Tracy A. Prime, Stefan Warrington, Julien Prudent, Georgina R. Bates, Dunja Aksentijević, Hiran A. Prag, Andrew M. James, Thomas Krieg, Richard C. Hartley, Michael P. Murphy
Publikováno v:
Redox Biology, Vol 55, Iss , Pp 102429- (2022)
Mitochondria-targeted H2S donors are thought to protect against acute ischemia-reperfusion (IR) injury by releasing H2S that decreases oxidative damage. However, the rate of H2S release by current donors is too slow to be effective upon administratio
Externí odkaz:
https://doaj.org/article/f01616a12f704ac39a2ca4515711e427
Autor:
Dylan G. Ryan, Elena V. Knatko, Alva M. Casey, Jens L. Hukelmann, Sharadha Dayalan Naidu, Alejandro J. Brenes, Thanapon Ekkunagul, Christa Baker, Maureen Higgins, Laura Tronci, Efterpi Nikitopolou, Tadashi Honda, Richard C. Hartley, Luke A.J. O’Neill, Christian Frezza, Angus I. Lamond, Andrey Y. Abramov, J. Simon C. Arthur, Doreen A. Cantrell, Michael P. Murphy, Albena T. Dinkova-Kostova
Publikováno v:
iScience, Vol 25, Iss 2, Pp 103827- (2022)
Summary: To overcome oxidative, inflammatory, and metabolic stress, cells have evolved cytoprotective protein networks controlled by nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) and its negative regulator, Kelch-like ECH associated protein
Externí odkaz:
https://doaj.org/article/59b0d8bd2ed646e68bc099da31cf94d0
Autor:
Chloe E. Myers, Charlotte J. Houldcroft, Sunando Roy, Ben K. Margetts, Timothy Best, Cristina Venturini, Jose A. Guerra-Assunção, Charlotte A. Williams, Rachel Williams, Helen Dunn, John C. Hartley, Kanchan Rao, Kathryn J. Rolfe, Judith Breuer
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
A recent surge in human mastadenovirus (HAdV) cases, including five deaths, amongst a haematopoietic stem cell transplant population led us to use whole genome sequencing (WGS) to investigate. We compared sequences from 37 patients collected over a 2
Externí odkaz:
https://doaj.org/article/360c8e1e8b4b4d158ae7b7e350ce08d7
Publikováno v:
BMC Veterinary Research, Vol 15, Iss 1, Pp 1-11 (2019)
Abstract Background Pigmentary keratitis (PK) is commonly recognised in Pugs, but its aetiology is not completely understood. The aim of this study was to determine the prevalence and associated features of PK in Pugs in the United Kingdom (UK). Resu
Externí odkaz:
https://doaj.org/article/ae5d16ace71f4ce0acc2cc93651fc3bc
Autor:
R. F. Kelly, S. Mazeri, C. Hartley, S. M. Hamman, V. Ngu Ngwa, E. F. Nkongho, V. Tanya, M. Sander, L. Ndip, K. L. Morgan, A. Muwonge, I. Handel, B. M. C. de Bronsvoort, D. J. L. Williams
Publikováno v:
BMC Veterinary Research, Vol 15, Iss 1, Pp 1-11 (2019)
Abstract Background Cattle rearing in Cameroon is both economically and culturally important, however parasitic diseases detrimentally impact cattle productivity. In sub-Saharan Africa bovine fasciolosis is generally attributed to F. gigantica, altho
Externí odkaz:
https://doaj.org/article/ec6b4165d5514dbca4f62ab6214237a4
Publikováno v:
Chemical Science. 14:4923-4927
A photochemical organocatalytic method for the enantioselective incorporation of perfluoroalkyl and trifluoromethyl fragments at the remote γ position of α-branched enals is reported.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecccf3261582eec502f68563e40a330e
https://doi.org/10.1039/d3sc01347b
https://doi.org/10.1039/d3sc01347b
Autor:
Timothy E. Beach, Hiran A. Prag, Laura Pala, Angela Logan, Margaret M. Huang, Anja V. Gruszczyk, Jack L. Martin, Krishnaa Mahbubani, Mazin O. Hamed, Sarah A. Hosgood, Michael L. Nicholson, Andrew M. James, Richard C. Hartley, Michael P. Murphy, Kourosh Saeb-Parsy
Publikováno v:
Redox Biology, Vol 36, Iss , Pp 101640- (2020)
Renal ischemia reperfusion (IR) injury leads to significant patient morbidity and mortality, and its amelioration is an urgent unmet clinical need. Succinate accumulates during ischemia and its oxidation by the mitochondrial enzyme succinate dehydrog
Externí odkaz:
https://doaj.org/article/038ddcdac34144049d5f8e694c7a30c8
Autor:
Anindya Roy Chowdhury, Jacek Zielonka, Balaraman Kalyanaraman, Richard C. Hartley, Michael P. Murphy, Narayan G. Avadhani
Publikováno v:
Redox Biology, Vol 36, Iss , Pp 101606- (2020)
The mitochondrial electron transport chain is a major source of reactive oxygen species (ROS) and is also a target of ROS, with an implied role in the stabilization of hypoxia-inducible factor (HIF) and induction of the AMPK pathway. Here we used var
Externí odkaz:
https://doaj.org/article/58c1fa1d4a5f46729fb31d06fda46e76
Autor:
Laura Pala, Hans M. Senn, Stuart T. Caldwell, Tracy A. Prime, Stefan Warrington, Thomas P. Bright, Hiran A. Prag, Claire Wilson, Michael P. Murphy, Richard C. Hartley
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
There is considerable interest in developing drugs and probes targeted to mitochondria in order to understand and treat the many pathologies associated with mitochondrial dysfunction. The large membrane potential, negative inside, across the mitochon
Externí odkaz:
https://doaj.org/article/55f3b6d8361e43d484624302dfb0660e
Autor:
Conor L Mallucci, Michael D Jenkinson, Elizabeth J Conroy, John C Hartley, Michaela Brown, Tracy Moitt, Joanne Dalton, Tom Kearns, Michael J Griffiths, Giovanna Culeddu, Tom Solomon, Dyfrig Hughes, Carrol Gamble, the BASICS study collaborators
Publikováno v:
Health Technology Assessment, Vol 24, Iss 17 (2020)
Background: Insertion of a ventriculoperitoneal shunt to treat hydrocephalus is one of the most common neurosurgical procedures worldwide. Shunt infection affects up to 15% of patients, resulting in long hospital stays, multiple surgeries and reduced
Externí odkaz:
https://doaj.org/article/ef472f04f29b422db05a4f1fcf747366