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Akademický článek

Search of brain-enriched proteins in salivary extracellular vesicles for their use as mental disease biomarkers: A pilot study of the neuronal glycoprotein M6a

Autor: Melisa C. Monteleone, Silvia C. Billi, Luciano Viale, Natalia P. Catoira, Alberto C. Frasch, Marcela A. Brocco

Publikováno v: Journal of Affective Disorders Reports, Vol 1, Iss , Pp 100003- (2020)

Background: Mental disorders affect millions of people worldwide. Their etiology is complex and the fact that the main effects occur in the brain hampers biochemical diagnosis. Therefore, biomarker finding in peripheral fluids such as serum or saliva

Externí odkaz: https://doaj.org/article/c62b4e54a3194c3ca3683a5a9e50b959

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Akademický článek

Identification of Potential Interacting Proteins With the Extracellular Loops of the Neuronal Glycoprotein M6a by TMT/MS

Autor: Gabriela I. Aparicio, Karina Formoso, Antonella León, Alberto C. Frasch, Camila Scorticati

Publikováno v: Frontiers in Synaptic Neuroscience, Vol 12 (2020)

Nowadays, great efforts are made to gain insight into the molecular mechanisms that underlie structural neuronal plasticity. Moreover, the identification of signaling pathways involved in the development of psychiatric disorders aids the screening of

Externí odkaz: https://doaj.org/article/aebff9592bf54b0798b15fedf54549f2

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Akademický článek

Alanine Scanning Mutagenesis of the C-Terminal Cytosolic End of Gpm6a Identifies Key Residues Essential for the Formation of Filopodia

Autor: Nicolás M. Rosas, Anabel Alvarez Juliá, Sofia E. Alzuri, Alberto C. Frasch, Beata Fuchsova

Publikováno v: Frontiers in Molecular Neuroscience, Vol 11 (2018)

Neuronal membrane glycoprotein M6a (Gpm6a) is a protein with four transmembrane regions and the N- and the C-ends facing the cytosol. It functions in processes of neuronal development, outgrowth of neurites, and formation of filopodia, spines, and sy

Externí odkaz: https://doaj.org/article/07b342576a4e409cb37e770de98ee27c

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Akademický článek

The Membrane Glycoprotein M6a Endocytic/Recycling Pathway Involves Clathrin-Mediated Endocytosis and Affects Neuronal Synapses

Autor: Micaela D. Garcia, Karina Formoso, Gabriela I. Aparicio, Alberto C. C. Frasch, Camila Scorticati

Publikováno v: Frontiers in Molecular Neuroscience, Vol 10 (2017)

Single point mutations or variations in the expression of the gene encoding the neuronal glycoprotein M6a have been associated with psychiatric disorders such as Alzheimer’s disease, depression and schizophrenia. In cultured neurons, M6a positively

Externí odkaz: https://doaj.org/article/98399851a2c642adbbe78c53426507b5

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Akademický článek

Genome-wide analysis of 3′-untranslated regions supports the existence of post-transcriptional regulons controlling gene expression in trypanosomes

Autor: Javier G. De Gaudenzi, Santiago J. Carmona, Fernán Agüero, Alberto C. Frasch

Publikováno v: PeerJ, Vol 1, p e118 (2013)

In eukaryotic cells, a group of messenger ribonucleic acids (mRNAs) encoding functionally interrelated proteins together with the trans-acting factors that coordinately modulate their expression is termed a post-transcriptional regulon, due to their

Externí odkaz: https://doaj.org/article/b722a29371e44bf19c697e75bb2f870d

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Akademický článek

M6 membrane protein plays an essential role in Drosophila oogenesis.

Autor: María Paula Zappia, Marcela Adriana Brocco, Silvia C Billi, Alberto C Frasch, María Fernanda Ceriani

Publikováno v: PLoS ONE, Vol 6, Iss 5, p e19715 (2011)

We had previously shown that the transmembrane glycoprotein M6a, a member of the proteolipid protein (PLP) family, regulates neurite/filopodium outgrowth, hence, M6a might be involved in neuronal remodeling and differentiation. In this work we focuse

Externí odkaz: https://doaj.org/article/a741b286c1f04f569a598995d0909996

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Akademický článek

Relevance of the diversity among members of the Trypanosoma cruzi trans-sialidase family analyzed with camelids single-domain antibodies.

Autor: Laura Ratier, Mariela Urrutia, Gastón Paris, Laura Zarebski, Alberto C Frasch, Fernando A Goldbaum

Publikováno v: PLoS ONE, Vol 3, Iss 10, p e3524 (2008)

The sialic acid present in the protective surface mucin coat of Trypanosoma cruzi is added by a membrane anchored trans-sialidase (TcTS), a modified sialidase that is expressed from a large gene family. In this work, we analyzed single domain camelid

Externí odkaz: https://doaj.org/article/b5e26391901449fdbdaa9803b2993841

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NMR Structural Study of TcUBP1, a Single RRM Domain Protein from Trypanosoma cruzi: Contribution of a β Hairpin to RNA Binding

Autor: Iván D'Orso, Laurent Volpon, and Alberto C. Frasch, Christopher R. Young, Kalle Gehring

Publikováno v: Biochemistry. 44:3708-3717

TcUBP1 is a trypanosome cytoplasmic RNA-binding protein containing a single, conserved RNA-recognition motif (RRM) domain involved in selective destabilization of U-rich mRNAs such as the Trypanosoma cruzi small mucin gene family mRNA, TcSMUG. TcUBP1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71209a82bec5748c75c9b40a75c89b0c
https://doi.org/10.1021/bi047450e

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Tyrosine 251 at the C-terminus of neuronal glycoprotein M6a is critical for neurite outgrowth

Autor: Karina, Formoso, Silvia C, Billi, Alberto C, Frasch, Camila, Scorticati

Publikováno v: Journal of neuroscience research. 93(2)

Neuronal glycoprotein M6a is involved in neuronal plasticity, promoting neurite and filopodia outgrowth and, likely, synaptogenesis. Polymorphisms in the human M6a gene GPM6A have recently been associated with mental illnesses such as schizophrenia,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::decaebcd21840883d86eaf8e7b1053e6
https://pubmed.ncbi.nlm.nih.gov/25242528

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