Zobrazeno 1 - 10
of 15
pro vyhledávání: '"A C, van der Graaf"'
Autor:
Daniël H. Swart, Martin de Haan, Jasper Stevens, Rob H. Henning, Sovan Adel, Adrianus C. van der Graaf, Nadir Ulu, Daan J. Touw, Guido Krenning
Publikováno v:
Toxicology Reports, Vol 12, Iss , Pp 345-355 (2024)
Noncommunicable Chronic Diseases (NCD) are a socioeconomic burden and considered one of the major health challenges for coming decades. Mitochondrial dysfunction has been implicated mechanistically in their pathophysiology. Therefore, targeting mitoc
Externí odkaz:
https://doaj.org/article/b8f0e0d668de4738b59950a932a68715
Publikováno v:
Geoscientific Model Development, Vol 13, Pp 2451-2474 (2020)
The nitrogen cycle has been continuously disrupted by human activity over the past century, resulting in almost a tripling of the total reactive nitrogen fixation in Europe. Consequently, excessive amounts of reactive nitrogen (Nr) have manifested in
Externí odkaz:
https://doaj.org/article/e911831da0814695894899c416506167
Publikováno v:
Atmospheric Chemistry and Physics, Vol 18, Pp 13173-13196 (2018)
Atmospheric levels of reactive nitrogen have increased substantially during the last century resulting in increased nitrogen deposition to ecosystems, causing harmful effects such as soil acidification, reduction in plant biodiversity and eutrophi
Externí odkaz:
https://doaj.org/article/44dc5fbecdcb41f1a68ef47096601fdb
Autor:
Lei Wang, Charlotte E. Pelgrim, Daniël H. Swart, Guido Krenning, Adrianus C. van der Graaf, Aletta D. Kraneveld, Thea Leusink-Muis, Ingrid van Ark, Johan Garssen, Gert Folkerts, Saskia Braber
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 4991 (2021)
Chronic obstructive pulmonary disease (COPD) caused by cigarette smoke (CS) is featured by oxidative stress and chronic inflammation. Due to the poor efficacy of standard glucocorticoid therapy, new treatments are required. Here, we investigated whet
Externí odkaz:
https://doaj.org/article/b269643808004d63aa639888e988f1ba
Autor:
S Tkáčiková, Guido Krenning, P. Vogelaar, Daniël Henri Swart, Robert H. Henning, Ľ Tkáčiková, D Nakladal, A C van der Graaf
Publikováno v:
European Journal of Pharmaceutical Sciences, 168:106033. ELSEVIER SCIENCE BV
Acute kidney injury (AKI) is a global healthcare burden attributable to high mortality and staggering costs of dialysis. The underlying causes of AKI include hypothermia and rewarming (H/R), ischemia/reperfusion (I/R), mitochondrial dysfunction and r
Autor:
Fatemeh Talaei, Hjalmar R Bouma, Adrianus C Van der Graaf, Arjen M Strijkstra, Martina Schmidt, Robert H Henning
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22568 (2011)
Biogenic amines have been demonstrated to protect cells from apoptotic cell death. Herein we show for the first time that serotonin and dopamine increase H(2)S production by the endogenous enzyme cystathionine-β-synthase (CBS) and protect cells agai
Externí odkaz:
https://doaj.org/article/cbbbd15bb6a74579bfe9c147d7bbb5e7
Autor:
D, Nakladal, H, Buikema, A Reyes, Romero, S P H, Lambooy, J, Bouma, G, Krenning, P, Vogelaar, A C, van der Graaf, M R, Groves, J, Kyselovic, R H, Henning, L E, Deelman
Publikováno v:
Scientific Reports
SUL-compounds are protectants from cold-induced ischemia and mitochondrial dysfunction. We discovered that adding SUL-121 to renal grafts during warm machine reperfusion elicits a rapid improvement in perfusion parameters. Therefore, we investigate t