Type I interferon signaling in dendritic cells limits direct antigen presentation and CD8+ T cell responses against an arthritogenic alphavirus

Autor: Christopher B. Bullock, Leran Wang, Brian C. Ware, Ngan Wagoner, Ray A. Ohara, Tian-Tian Liu, Pritesh Desai, Bjoern Peters, Kenneth M. Murphy, Scott A. Handley, Thomas E. Morrison, Michael S. Diamond

Publikováno v: mBio, Vol 15, Iss 12 (2024)

ABSTRACT Ross River virus (RRV) and other alphaviruses cause chronic musculoskeletal syndromes that are associated with viral persistence, which suggests deficits in immune clearance mechanisms, including CD8+ T-cell responses. Here, we used a recomb

Externí odkaz: https://doaj.org/article/abb30f3dcbfe47739c933318bc3cd7c9

Urine tenofovir testing for real‐time PrEP adherence feedback: a qualitative study involving transgender women in Uganda

Autor: Andrew Mujugira, Beyonce Karungi, Jackson Mugisha, Agnes Nakyanzi, Olivia Nampewo, Faith Naddunga, Brenda Kamusiime, Rogers Nsubuga, Kikulwe R. Nyanzi, Timothy R. Muwonge, Monique A. Wyatt, Norma C. Ware, Monica Gandhi, Jessica E. Haberer

Publikováno v: Journal of the International AIDS Society, Vol 27, Iss 5, Pp n/a-n/a (2024)

Abstract Introduction Adherence counselling with point‐of‐care (POC) drug‐level feedback using a novel tenofovir assay may support pre‐exposure prophylaxis (PrEP) adherence; however, perceptions of urine testing and its impact on adherence ar

Externí odkaz: https://doaj.org/article/adb5b17a22a8484786b4c01e657d7a00

Chikungunya virus infection disrupts MHC-I antigen presentation via nonstructural protein 2.

Autor: Brian C Ware, M Guston Parks, Mariana O L da Silva, Thomas E Morrison

Publikováno v: PLoS Pathogens, Vol 20, Iss 3, p e1011794 (2024)

Infection by chikungunya virus (CHIKV), a mosquito-borne alphavirus, causes severe polyarthralgia and polymyalgia, which can last in some people for months to years. Chronic CHIKV disease signs and symptoms are associated with the persistence of vira

Externí odkaz: https://doaj.org/article/dc18606325354d899c3e8a7944242b74

How PrEP delivery was integrated into public ART clinics in central Uganda: A qualitative analysis of implementation processes.

Autor: Monique A Wyatt, Emily E Pisarski, Alisaati Nalumansi, Vicent Kasiita, Brenda Kamusiime, Grace K Nalukwago, Dorothy Thomas, Timothy R Muwonge, Andrew Mujugira, Renee Heffron, Norma C Ware, Partners PrEP Program Study Team

Publikováno v: PLOS Global Public Health, Vol 4, Iss 3, p e0002916 (2024)

Tailored delivery strategies are important for optimizing the benefit and overall reach of PrEP in sub-Saharan Africa. An integrated approach of delivering time-limited PrEP in combination with ART to serodifferent couples encourages PrEP use in the

Externí odkaz: https://doaj.org/article/e467476fbf234c2c9ebef0a188726ede

Models of classroom assessment for course-based research experiences

Autor: David I. Hanauer, Tong Zhang, Mark J. Graham, Sandra D. Adams, Yesmi Patricia Ahumada-Santos, Richard M. Alvey, Mauricio S. Antunes, Mary A. Ayuk, María Elena Báez-Flores, Christa T. Bancroft, Tonya C. Bates, Meghan J. Bechman, Elizabeth Behr, Andrea R. Beyer, Rebecca L. Bortz, Dane M. Bowder, Laura A. Briggs, Victoria Brown-Kennerly, Michael A. Buckholt, Sharon K. Bullock, Kristen A. Butela, Christine A. Byrum, Steven M. Caruso, Catherine P. Chia, Rebecca A. Chong, Hui-Min Chung, Kari L. Clase, Sean T. Coleman, D. Parks Collins, Stephanie B. Conant, Brett M. Condon, Pamela L. Connerly, Bernadette J. Connors, Jennifer E. Cook-Easterwood, Katie E. Crump, Tom D’Elia, Megan K. Dennis, Linda C. DeVeaux, Lautaro Diacovich, Iain Duffy, Nicholas P. Edgington, Dustin C. Edwards, Tenny O. G. Egwuatu, Elvira R. Eivazova, Patricia C. Fallest-Strobl, Christy L. Fillman, Ann M. Findley, Emily Fisher, Matthew R. Fisher, Marie P. Fogarty, Amanda C. Freise, Victoria J. Frost, Maria D. Gainey, Amaya M. Garcia Costas, Atenea A. Garza, Hannah E. Gavin, Raffaella Ghittoni, Bryan Gibb, Urszula P. Golebiewska, Anna S. Grinath, Susan M. R. Gurney, Rebekah F. Hare, Steven G. Heninger, John M. Hinz, Lee E. Hughes, Pradeepa Jayachandran, Kristen C. Johnson, Allison A. Johnson, Michelle Kanther, Margaret Kenna, Bridgette L. Kirkpatrick, Karen K. Klyczek, Kathryn P. Kohl, Michael Kuchka, Amber J. LaPeruta, Julia Y. Lee-Soety, Lynn O. Lewis, Heather M. Lindberg, Jaclyn A. Madden, Sergei A. Markov, Matthew D. Mastropaolo, Vinayak Mathur, Sean P. McClory, Evan C. Merkhofer, Julie A. Merkle, Scott F. Michael, Jon C. Mitchell, Sally D. Molloy, Denise L. Monti, María Alejandra Mussi, Holly Nance, Fernando E. Nieto-Fernandez, Jillian C. Nissen, Imade Y. Nsa, Mary G. O’Donnell, Shallee T. Page, Andrea Panagakis, Jesús Ricardo Parra-Unda, Tara A. Pelletier, Tiara G. Perez Morales, Nick T. Peters, Vipaporn Phuntumart, Richard S. Pollenz, Mary L. Preuss, David P. Puthoff, Muideen K. Raifu, Nathan S. Reyna, Claire A. Rinehart, Jessica M. Rocheleau, Ombeline Rossier, Adam D. Rudner, Elizabeth E. Rueschhoff, Amy Ryan, Sanghamitra Saha, Christopher D. Shaffer, Mary Ann V. Smith, Amy B. Sprenkle, Christy L. Strong, C. Nicole Sunnen, Brian P. Tarbox, Louise Temple, Kara R. Thoemke, Michael A. Thomas, Deborah M. Tobiason, Sara S. Tolsma, Julie Torruellas Garcia, Megan S. Valentine, Edwin Vazquez, Robert E. Ward, Catherine M. Ward, Vassie C. Ware, Marcie H. Warner, Jacqueline M. Washington, Daniel E. Westholm, Keith A. Wheaton, Beth M. Wilkes, Elizabeth C. Williams, William H. Biederman, Steven G. Cresawn, Danielle M. Heller, Deborah Jacobs-Sera, Graham F. Hatfull, David J. Asai, Viknesh Sivanathan

Publikováno v: Frontiers in Education, Vol 8 (2023)

Course-based research pedagogy involves positioning students as contributors to authentic research projects as part of an engaging educational experience that promotes their learning and persistence in science. To develop a model for assessing and gr

Externí odkaz: https://doaj.org/article/dbc6c31976584d29ae88631edf9ca15d