Zobrazeno 1 - 10
of 395
pro vyhledávání: '"A C, Tsoi"'
Autor:
Rachana Haliyur, MD, PhD, David H. Parkinson, MS, Feiyang Ma, PhD, Jing Xu, PhD, Qiang Li, MD, PhD, Yuanhao Huang, Lam C. Tsoi, PhD, Rachael Bogle, MS, Jie Liu, PhD, Johann E. Gudjonsson, MD, Rajesh C. Rao, MD
Publikováno v:
Ophthalmology Science, Vol 4, Iss 6, Pp 100539- (2024)
Purpose: Current therapies for proliferative diabetic retinopathy (PDR) do not specifically target VEGF-independent, cell-type–specific processes that lead to vision loss, such as inflammatory pathways. This study aimed to identify targetable cell
Externí odkaz:
https://doaj.org/article/f4ad998418104f48bf24a27ebc226ad3
Autor:
Junyan Duan, Michelle N. Ngo, Satya Swaroop Karri, Lam C. Tsoi, Johann E. Gudjonsson, Babak Shahbaba, John Lowengrub, Bogi Andersen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract As the circadian clock regulates fundamental biological processes, disrupted clocks are often observed in patients and diseased tissues. Determining the circadian time of the patient or the tissue of focus is essential in circadian medicine
Externí odkaz:
https://doaj.org/article/4081073e60234614bf817f5fce0ddaca
Autor:
Evgeniya Petrova, Jesús María López-Gay, Matthias Fahrner, Florent Leturcq, Jean-Pierre de Villartay, Claire Barbieux, Patrick Gonschorek, Lam C. Tsoi, Johann E. Gudjonsson, Oliver Schilling, Alain Hovnanian
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-24 (2024)
Abstract Netherton syndrome (NS) is a rare skin disease caused by loss-of-function mutations in the serine peptidase inhibitor Kazal type 5 (SPINK5) gene. Disease severity and the lack of efficacious treatments call for a better understanding of NS m
Externí odkaz:
https://doaj.org/article/a4b9cbf4d219401da0ec2c2e31fec3de
Autor:
Feiyang Ma, Pei-Suen Tsou, Mehrnaz Gharaee-Kermani, Olesya Plazyo, Xianying Xing, Joseph Kirma, Rachael Wasikowski, Grace A. Hile, Paul W. Harms, Yanyun Jiang, Enze Xing, Mio Nakamura, Danielle Ochocki, William D. Brodie, Shiv Pillai, Emanual Maverakis, Matteo Pellegrini, Robert L. Modlin, John Varga, Lam C. Tsoi, Robert Lafyatis, J. Michelle Kahlenberg, Allison C. Billi, Dinesh Khanna, Johann E. Gudjonsson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Systemic sclerosis (SSc) is a devastating autoimmune disease characterized by excessive production and accumulation of extracellular matrix, leading to fibrosis of skin and other internal organs. However, the main cellular participants in SS
Externí odkaz:
https://doaj.org/article/3b5a5e9a32fc4187b638ed4405b8d22c
Autor:
Robert J. Millikin, Kalpana Raja, John Steill, Cannon Lock, Xuancheng Tu, Ian Ross, Lam C. Tsoi, Finn Kuusisto, Zijian Ni, Miron Livny, Brian Bockelman, James Thomson, Ron Stewart
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-14 (2023)
Abstract Background The PubMed archive contains more than 34 million articles; consequently, it is becoming increasingly difficult for a biomedical researcher to keep up-to-date with different knowledge domains. Computationally efficient and interpre
Externí odkaz:
https://doaj.org/article/d8781b15ff3f482f95868b84ad1c6b1a
Autor:
Ranjitha Uppala, Mrinal K. Sarkar, Kelly Z. Young, Feiyang Ma, Pritika Vemulapalli, Rachael Wasikowski, Olesya Plazyo, William R. Swindell, Emanual Maverakis, Mehrnaz Gharaee-Kermani, Allison C. Billi, Lam C. Tsoi, J. Michelle Kahlenberg, Johann E. Gudjonsson
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108986- (2024)
Summary: Interferon (IFN) activity exhibits a gender bias in human skin, skewed toward females. We show that HERC6, an IFN-induced E3 ubiquitin ligase, is induced in human keratinocytes through the epidermal type I IFN; IFN-κ. HERC6 knockdown in hum
Externí odkaz:
https://doaj.org/article/87cba07b11fb49b59bbc593a99230d5e
Autor:
Erez Cohen, Craig N. Johnson, Rachael Wasikowski, Allison C. Billi, Lam C. Tsoi, J. Michelle Kahlenberg, Johann E. Gudjonsson, Pierre A. Coulombe
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108805- (2024)
Summary: A group of keratin intermediate filament genes, the type II KRT6A-C and type I KRT16 and KRT17, are deemed stress responsive as they are induced in keratinocytes of surface epithelia in response to environmental stressors, in skin disorders
Externí odkaz:
https://doaj.org/article/b80278a23f364084a5342052f0952287
Autor:
Qinmengge Li, Matthew T. Patrick, Sutharzan Sreeskandarajan, Jian Kang, J. Michelle Kahlenberg, Johann E. Gudjonsson, Zhi He, Lam C. Tsoi
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
IntroductionThe utilization of large-scale claims databases has greatly improved the management, accessibility, and integration of extensive medical data. However, its potential for systematically identifying comorbidities in the context of skin dise
Externí odkaz:
https://doaj.org/article/0fbcd6f6234f491598f3c09a1839c789
Autor:
Feiyang Ma, Olesya Plazyo, Allison C. Billi, Lam C. Tsoi, Xianying Xing, Rachael Wasikowski, Mehrnaz Gharaee-Kermani, Grace Hile, Yanyun Jiang, Paul W. Harms, Enze Xing, Joseph Kirma, Jingyue Xi, Jer-En Hsu, Mrinal K. Sarkar, Yutein Chung, Jeremy Di Domizio, Michel Gilliet, Nicole L. Ward, Emanual Maverakis, Eynav Klechevsky, John J. Voorhees, James T. Elder, Jun Hee Lee, J. Michelle Kahlenberg, Matteo Pellegrini, Robert L. Modlin, Johann E. Gudjonsson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract The immunopathogenesis of psoriasis, a common chronic inflammatory disease of the skin, is incompletely understood. Here we demonstrate, using a combination of single cell and spatial RNA sequencing, IL-36 dependent amplification of IL-17A a
Externí odkaz:
https://doaj.org/article/7d7e27df0a374d5eb3a7f42f1d8c5e5f
Autor:
Chachrit Khunsriraksakul, Qinmengge Li, Havell Markus, Matthew T. Patrick, Renan Sauteraud, Daniel McGuire, Xingyan Wang, Chen Wang, Lida Wang, Siyuan Chen, Ganesh Shenoy, Bingshan Li, Xue Zhong, Nancy J. Olsen, Laura Carrel, Lam C. Tsoi, Bibo Jiang, Dajiang J. Liu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
The genetic basis of systemic lupus erythematosus is not completely understood. Here, the authors perform multi-ancestry and multi-trait meta-analyses to identify 16 novel genetic loci and demonstrate the utility of polygenic risk score in clinical r
Externí odkaz:
https://doaj.org/article/967b70f77d724ef59ee7f509410de467