The germline factor DDX4 contributes to the chemoresistance of small cell lung cancer cells

Autor: Christopher Noyes, Shunsuke Kitajima, Fengkai Li, Yusuke Suita, Saradha Miriyala, Shakson Isaac, Nagib Ahsan, Erik Knelson, Amir Vajdi, Tetsuo Tani, Tran C. Thai, Derek Xu, Junko Murai, Nikos Tapinos, Chiaki Takahashi, David A. Barbie, Mamiko Yajima

Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)

DDX4, a conserved germline factor and RNA helicase, increases small cell lung cancer cell survival by regulating DNA damage and immune response pathways and contributes to cisplatin-mediated drug resistance.

Externí odkaz: https://doaj.org/article/fe86a334b97d47fd9a7feeb2bdd23dba

Vaccine Candidates for the Control and Prevention of the Sexually Transmitted Disease Gonorrhea

Autor: Ethan C. Haese, Van C. Thai, Charlene M. Kahler

Publikováno v: Vaccines, Vol 9, Iss 7, p 804 (2021)

The World Health Organization (WHO) has placed N. gonorrhoeae on the global priority list of antimicrobial resistant pathogens and is urgently seeking the development of new intervention strategies. N. gonorrhoeae causes 86.9 million cases globally p

Externí odkaz: https://doaj.org/article/d479f04ee3974c00a03252d47ffce2b1

Data from Activation of Tumor-Cell STING Primes NK-Cell Therapy

Autor: David A. Barbie, Raphael Bueno, Cloud P. Paweletz, Rizwan Romee, Michael Y. Tolstorukov, Juan J. Miret, Pasi A. Jänne, Eric L. Smith, Neil Lineberry, Alexander Parent, Richard C. Gregory, Vicky A. Appleman, Adnan O. Abu-Yousif, William G. Richards, Assunta De Rienzo, Marina Vivero, Israel Cañadas, Ze-Hua Li, Pinar O. Eser, Antja-Voy Hartley, Thomas P. Albertson, Timothy J. Haggerty, Kartika Venugopal, Corinne E. Gustafson, Tran C. Thai, Saemi Han, Arrien A. Bertram, Minh Ha, Ha V. Vo, Ari Zlota, Anna M. Lee-Hassett, Pieter J. Schol, Tetsuo Tani, Navin R. Mahadevan, Erin Shannon, Cameron M. Messier, Bonje Obua, Nathaniel Spicer, Brandon Piel, Minyue Chen, Brittany Meisenheimer, Moataz Noureddine, Ismail Ozgenc, Matthew A. Booker, Patrick H. Lizotte, Marco Campisi, Mubin Tarannum, Elena V. Ivanova, Erik H. Knelson

Activation of the stimulator of interferon genes (STING) pathway promotes antitumor immunity but STING agonists have yet to achieve clinical success. Increased understanding of the mechanism of action of STING agonists in human tumors is key to devel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34335b05bd2da45a66fc885095d546f7
https://doi.org/10.1158/2326-6066.c.6550907

Supplementary Data from Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

Autor: David A. Barbie, Cloud Peter Paweletz, David Dornan, Kwok-Kin Wong, Genevieve M. Boland, Roger D. Kamm, Keith T. Flaherty, F. Stephen Hodi, Patrick A. Ott, Jochen H. Lorch, Paul T. Kirschmeier, Gordon J. Freeman, Eliezer M. Van Allen, Levi A. Garraway, Meenhard Herlyn, Juan Miret, Charles H. Yoon, Raphael Bueno, William G. Richards, Joshua Wong, Vivek Sivathanu, Thanh U. Barbie, Benchun Miao, Rohit Thummalapalli, Shunsuke Kitajima, Brian C. Miller, James M. Cleary, Sareh Parangi, Viswanath Gunda, Guilherme Rabinowits, Nicole R. LeBoeuf, Manisha Thakuria, Benjamin Izar, Parin Shah, Mei-Ju Su, Lisa Cameron, Anat O. Stemmer-Rachamimov, Jean-Pierre Eliane, Adriano Piris, Mai P. Hoang, Wei Huang, Glenn J. Hanna, Shuai Li, Hua Zhang, Eric S. Wang, Raven Vlahos, Marc R. Hammond, Tran C. Thai, Israel Cañadas, Michal Barzily-Rokni, Zhiheng Jia, Lance Stapleton, Maria Anguiano, Lauren Keogh, Robert E. Jones, Asaf Rotem, Alicia Smart, Bart Phillips, Prafulla C. Gokhale, Andrew Portell, Joshua A. Kaplan, Chandrasekar Venkataramani, Max Quinn, Ashley Merlino, Jong Wook Kim, Hans Vitzthum, Mark Bittinger, Sangeetha Palakurthi, Zhi Wei, Chaoran Cheng, Tian Tian, Gao Zhang, William Walker, Meng Xiao He, Diana Miao, Hongye Liu, Jiehui Deng, Michaela Bowden, Chensheng W. Zhou, Susanna Stinson, Elena Ivanova, Patrick H. Lizotte, Amir R. Aref, Russell W. Jenkins

Supplementary Figure Legends and Figures

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c2e4f5e724ad7a5b7c5e1c4faeafecb
https://doi.org/10.1158/2159-8290.22531831.v1

Supp. Movie 1 from Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

Autor: David A. Barbie, Cloud Peter Paweletz, David Dornan, Kwok-Kin Wong, Genevieve M. Boland, Roger D. Kamm, Keith T. Flaherty, F. Stephen Hodi, Patrick A. Ott, Jochen H. Lorch, Paul T. Kirschmeier, Gordon J. Freeman, Eliezer M. Van Allen, Levi A. Garraway, Meenhard Herlyn, Juan Miret, Charles H. Yoon, Raphael Bueno, William G. Richards, Joshua Wong, Vivek Sivathanu, Thanh U. Barbie, Benchun Miao, Rohit Thummalapalli, Shunsuke Kitajima, Brian C. Miller, James M. Cleary, Sareh Parangi, Viswanath Gunda, Guilherme Rabinowits, Nicole R. LeBoeuf, Manisha Thakuria, Benjamin Izar, Parin Shah, Mei-Ju Su, Lisa Cameron, Anat O. Stemmer-Rachamimov, Jean-Pierre Eliane, Adriano Piris, Mai P. Hoang, Wei Huang, Glenn J. Hanna, Shuai Li, Hua Zhang, Eric S. Wang, Raven Vlahos, Marc R. Hammond, Tran C. Thai, Israel Cañadas, Michal Barzily-Rokni, Zhiheng Jia, Lance Stapleton, Maria Anguiano, Lauren Keogh, Robert E. Jones, Asaf Rotem, Alicia Smart, Bart Phillips, Prafulla C. Gokhale, Andrew Portell, Joshua A. Kaplan, Chandrasekar Venkataramani, Max Quinn, Ashley Merlino, Jong Wook Kim, Hans Vitzthum, Mark Bittinger, Sangeetha Palakurthi, Zhi Wei, Chaoran Cheng, Tian Tian, Gao Zhang, William Walker, Meng Xiao He, Diana Miao, Hongye Liu, Jiehui Deng, Michaela Bowden, Chensheng W. Zhou, Susanna Stinson, Elena Ivanova, Patrick H. Lizotte, Amir R. Aref, Russell W. Jenkins

PDOTS Movie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b5bb8094691604919e8b9895ba64f60
https://doi.org/10.1158/2159-8290.22531843.v1