Zobrazeno 1 - 10
of 28
pro vyhledávání: '"A C, Sulpizio"'
Autor:
Henry M. Sarau, Nambi Aiyar, Eliot H. Ohlstein, Valerie Piercy, Anthony C Sulpizio, Robert N. Willette, Robert S. Ames, Stephen A. Douglas
Publikováno v:
British Journal of Pharmacology. 131:1262-1274
1. Urotensin-II (U-II) and its G-protein-coupled receptor, GPR14, are expressed within mammalian cardiac and peripheral vascular tissue and, as such, may regulate mammalian cardiovascular function. The present study details the vasoconstrictor profil
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 33
Atheroprotective properties of high-density lipoproteins (HDL) may be due to the ability to remove lipids from peripheral cells to the liver for excretion during reverse cholesterol transport (RCT). Assays that measure functionality of serum HDL are
Publikováno v:
Archiv der Pharmazie. 329:125-132
Vinylogous (Groups III and V) and acetylenologous (Group IV) analogs of the classical β-adrenergic agents - stimulant and blockers - were prepared in order to evaluate the effect of degree of saturation, position of unsaturation and rigidity of the
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 32
In an effort to reduce the time and labor resources required for the standard HDL isolation protocol using sequential ultracentrifugation, our laboratory has investigated a modified process for isolation of HDL from human serum. Our method employs an
Publikováno v:
Stroke. 25:2450-2455
(+/-)-SB 209670, a potent nonpeptide endothelin (ET) receptor antagonist, was used to investigate the potential role of ET in cerebral vasospasm associated with subarachnoid hemorrhage. The effects of (+/-)-SB 209670 were evaluated in isolated segmen
Publikováno v:
ChemInform. 27
Autor:
Jeffrey D. Bray, Qi Wang, Ryan J. Boyle, Nicholas J. Laping, Eugene T. Grygielko, Lindsay Glace, Anthony C. Sulpizio
Publikováno v:
Steroids. 74(13-14)
Endometriosis, defined as the presence of endometrial glands and stroma at extra-uterine sites, is a gynecological condition that affects women of reproductive age. Consistent with its uterine origins, endometriotic lesions and resulting symptoms are
Autor:
Jian Jin, Xiaoping Hou, Charlene W. Wu, Dwight M. Morrow, Richard M. Edwards, Zhimin Du, Ning Wang, Rakesh Nagilla, Mark Pullen, Mark A. Hilfiker, Melanie Nord, A C Sulpizio, Jon-Paul Jaworski, Harvey E. Fries
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(15)
This Letter discloses a series of 2-aminothiadiazole amides as selective EP 3 receptor antagonists. SAR optimization resulted in compounds with excellent functional activity in vitro. In addition, efforts to optimize DMPK properties in the rat are di
Autor:
Jeffrey D. Bray, Beat M. Jucker, Anthony C. Sulpizio, David P. Brooks, Robin E. Haimbach, Stephen C. Lenhard
Publikováno v:
Fertility and sterility. 88
Objective To non-invasively characterize ectopic uterine tissue (EUT) development in a modified autologous rat surgical model of endometriosis using magnetic resonance imaging (MRI). Design Investigational MRI study. Setting A pharmaceutical company.
Autor:
Timothy D. Westfall, A C Sulpizio, Ishrat J. Mannan, Susan Gruver, V. Nambi Aiyar, Gerald P. McCafferty, Lisa C. Contino, Mark Pullen, J. Paul Hieble, Jyoti Disa
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 301(3)
Two endogenous receptors for the potent smooth muscle-stimulating peptide neuromedin U (NmU) have recently been identified and cloned. Pharmacological, binding, and expression studies were conducted in an attempt to determine the receptor(s) involved