Zobrazeno 1 - 10
of 571
pro vyhledávání: '"A C, Sims"'
Autor:
Amie J. Eisfeld, Lindsey N. Anderson, Shufang Fan, Kevin B. Walters, Peter J. Halfmann, Danielle Westhoff Smith, Larissa B. Thackray, Qing Tan, Amy C. Sims, Vineet D. Menachery, Alexandra Schäfer, Timothy P. Sheahan, Adam S. Cockrell, Kelly G. Stratton, Bobbie-Jo M. Webb-Robertson, Jennifer E. Kyle, Kristin E. Burnum-Johnson, Young-Mo Kim, Carrie D. Nicora, Zuleyma Peralta, Alhaji U. N’jai, Foday Sahr, Harm van Bakel, Michael S. Diamond, Ralph S. Baric, Thomas O. Metz, Richard D. Smith, Yoshihiro Kawaoka, Katrina M. Waters
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-34 (2024)
Abstract Human infections caused by viral pathogens trigger a complex gamut of host responses that limit disease, resolve infection, generate immunity, and contribute to severe disease or death. Here, we present experimental methods and multi-omics d
Externí odkaz:
https://doaj.org/article/150f2ad7d6bb4178aa94bba0ca48d3b5
Autor:
Yolanda López-Maldonado, Janet Anstee, Merrie Beth Neely, Jérôme Marty, Diana Mastracci, Happyness Ngonyani, Igor Ogashawara, Anham Salyani, Kabindra Sharma, Neil C. Sims
Publikováno v:
Frontiers in Water, Vol 6 (2024)
Indigenous Knowledge, observations and understandings of Earth processes are not sufficiently included in global Earth Observations. Drawing on the results obtained during a 3-day hackathon event, we present evidence, best practices and recommendatio
Externí odkaz:
https://doaj.org/article/ba84a236e18c4c1d93d91e3cf3737f59
Autor:
Ethan J. Fritch, Wes Sanders, Amy C. Sims, Laura E. Herring, Natalie K. Barker, Athena A. Schepmoes, Karl K. Weitz, Jordan R. Texier, Dirk P. Dittmer, Lee M. Graves, Richard D. Smith, Katrina M. Waters, Nathaniel J. Moorman, Ralph S. Baric, Rachel L. Graham
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106780- (2023)
Summary: Among all RNA viruses, coronavirus RNA transcription is the most complex and involves a process termed “discontinuous transcription” that results in the production of a set of 3′-nested, co-terminal genomic and subgenomic RNAs during i
Externí odkaz:
https://doaj.org/article/2bc0d11dd93b4dea94883e22e03d5645
Autor:
Lisa M. Bramer, Robert D. Hontz, Amie J. Eisfeld, Amy C. Sims, Young-Mo Kim, Kelly G. Stratton, Carrie D. Nicora, Marina A. Gritsenko, Athena A. Schepmoes, Osamu Akasaka, Michiko Koga, Takeya Tsutsumi, Morio Nakamura, Ichiro Nakachi, Rie Baba, Hiroki Tateno, Shoji Suzuki, Hideaki Nakajima, Hideaki Kato, Kazunari Ishida, Makoto Ishii, Yoshifumi Uwamino, Keiko Mitamura, Vanessa L. Paurus, Ernesto S. Nakayasu, Isaac K. Attah, Andrew G. Letizia, Katrina M. Waters, Thomas O. Metz, Karen Corson, Yoshihiro Kawaoka, Vincent R. Gerbasi, Hiroshi Yotsuyanagi, Kiyoko Iwatsuki-Horimoto
Publikováno v:
Heliyon, Vol 9, Iss 3, Pp e13795- (2023)
The detailed mechanisms of COVID-19 infection pathology remain poorly understood. To improve our understanding of SARS-CoV-2 pathology, we performed a multi-omics and correlative analysis of an immunologically naïve SARS-CoV-2 clinical cohort from b
Externí odkaz:
https://doaj.org/article/53d6cd1dfc184584aa9c45e5874a5dd0
Autor:
Zachary C. Sims, Hunter B. Henderson, Michael J. Thompson, Rakesh P. Chaudhary, Joshua A. Hammons, Jan Ilavsky, David Weiss, Kevin Anderson, Ryan Ott, Orlando Rios
Publikováno v:
European Journal of Materials, Vol 1, Iss 1, Pp 3-18 (2022)
Secondary (recycled) Al is increasingly used in castings due to its lower cost and carbon footprint relative to primary Al. However, the presence of certain impurity elements in secondary Al degrades its properties, often requiring dilution or downgr
Externí odkaz:
https://doaj.org/article/2b2362c2869043a9a866a07281594f27
Publikováno v:
BMC Medical Education, Vol 21, Iss 1, Pp 1-7 (2021)
Abstract Background Information learned over a longer period of time has been shown to result in better long-term knowledge retention than information learned over a shorter period of time. In order to address multiple curricular goals, the timing an
Externí odkaz:
https://doaj.org/article/69ee74cc3e3e48f08e5ffd72dd16e2c3
Autor:
Aki T. Chaffin, Karlton R. Larson, Kuei-Pin Huang, Chih-Ting Wu, Nadejda Godoroja, Yanbin Fang, Devi Jayakrishnan, Karla A. Soto Sauza, Landon C. Sims, Niloufar Mohajerani, Michael L. Goodson, Karen K. Ryan
Publikováno v:
JCI Insight, Vol 7, Iss 19 (2022)
The liver regulates energy partitioning and use in a sex-dependent manner, coupling hepatic substrate availability to female reproductive status. Fibroblast growth factor 21 (FGF21) is a hepatokine produced in response to metabolic stress that adapti
Externí odkaz:
https://doaj.org/article/1d9e6fc1c88b40d98447685025909051
Autor:
Song Feng, Emily Heath, Brett Jefferson, Cliff Joslyn, Henry Kvinge, Hugh D. Mitchell, Brenda Praggastis, Amie J. Eisfeld, Amy C. Sims, Larissa B. Thackray, Shufang Fan, Kevin B. Walters, Peter J. Halfmann, Danielle Westhoff-Smith, Qing Tan, Vineet D. Menachery, Timothy P. Sheahan, Adam S. Cockrell, Jacob F. Kocher, Kelly G. Stratton, Natalie C. Heller, Lisa M. Bramer, Michael S. Diamond, Ralph S. Baric, Katrina M. Waters, Yoshihiro Kawaoka, Jason E. McDermott, Emilie Purvine
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-21 (2021)
Abstract Background Representing biological networks as graphs is a powerful approach to reveal underlying patterns, signatures, and critical components from high-throughput biomolecular data. However, graphs do not natively capture the multi-way rel
Externí odkaz:
https://doaj.org/article/3730664a2b894f34b1b4e404f44398c0
Autor:
Kirsten P. Stone, Sujoy Ghosh, Jean Paul Kovalik, Manda Orgeron, Desiree Wanders, Landon C. Sims, Thomas W. Gettys
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract The initial sensing of dietary methionine restriction (MR) occurs in the liver where it activates an integrated stress response (ISR) that quickly reduces methionine utilization. The ISR program is regulated in part by ATF4, but ATF4’s pro
Externí odkaz:
https://doaj.org/article/47e11d4a223a47389d7444778bbfe088
Autor:
Timothy P. Sheahan, Amy C. Sims, Sarah R. Leist, Alexandra Schäfer, John Won, Ariane J. Brown, Stephanie A. Montgomery, Alison Hogg, Darius Babusis, Michael O. Clarke, Jamie E. Spahn, Laura Bauer, Scott Sellers, Danielle Porter, Joy Y. Feng, Tomas Cihlar, Robert Jordan, Mark R. Denison, Ralph S. Baric
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Remdesivir (RDV) is a broad-spectrum antiviral drug with activity against MERS coronavirus, but in vivo efficacy has not been evaluated. Here, the authors show that RDV has superior anti-MERS activity in vitro and in vivo compared to combination ther
Externí odkaz:
https://doaj.org/article/f17353d0fecb47bb853401bd79786ace