Výsledky vyhledávání - "A C, Rapraeger"

Akademický článek

Syndecans and Their Synstatins: Targeting an Organizer of Receptor Tyrosine Kinase Signaling at the Cell-Matrix Interface

Autor: Alan C. Rapraeger

Publikováno v: Frontiers in Oncology, Vol 11 (2021)

Receptor tyrosine kinases (RTKs) and integrin matrix receptors have well-established roles in tumor cell proliferation, invasion and survival, often functioning in a coordinated fashion at sites of cell-matrix adhesion. Central to this coordination a

Externí odkaz: https://doaj.org/article/c451e6ab641240dabb6ab835fa364640

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Inhibiting IGF1R-mediated Survival Signaling in Head and Neck Cancer with the Peptidomimetic SSTNIGF1R

Autor: Noah A. Stueven, DeannaLee M. Beauvais, Rong Hu, Randall J. Kimple, Alan C. Rapraeger

Publikováno v: Cancer Research Communications. 3:97-108

Previous studies have shown that the type I IGFR (IGF1R) suppresses apoptosis when it is autoactivated by coupling its extracellular domain to a matrix adhesion receptor complex consisting of syndecan-1 (Sdc1) and αvβ3 or αvβ5 integrin. We now re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf0b9a79b453f5effd611e069598a8fc
https://doi.org/10.1158/2767-9764.crc-22-0274

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Supplementary Material and Methods from Syndecan-1 (CD138) Suppresses Apoptosis in Multiple Myeloma by Activating IGF1 Receptor: Prevention by SynstatinIGF1R Inhibits Tumor Growth

Autor: Alan C. Rapraeger, Ralph D. Sanderson, Yang Yang, Oisun Jung, DeannaLee M. Beauvais

Materials and Methods that apply to the supplemental figures

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e162a5cfb9d6dadbccd88cbb22f83880
https://doi.org/10.1158/0008-5472.22411506

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Supplementary Figure Legends from Syndecan-1 (CD138) Suppresses Apoptosis in Multiple Myeloma by Activating IGF1 Receptor: Prevention by SynstatinIGF1R Inhibits Tumor Growth

Autor: Alan C. Rapraeger, Ralph D. Sanderson, Yang Yang, Oisun Jung, DeannaLee M. Beauvais

Legends for supplemental figures

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ada6ed622708aa0c4c638d327927b11
https://doi.org/10.1158/0008-5472.22411509

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SUPPLEMENTARY FIGURE 1. Primary CD138+-myeloma cells in bone marrow aspirates express αvβ3/αvβ5 integrins and IGF1R. from Syndecan-1 (CD138) Suppresses Apoptosis in Multiple Myeloma by Activating IGF1 Receptor: Prevention by SynstatinIGF1R Inhibits Tumor Growth

Autor: Alan C. Rapraeger, Ralph D. Sanderson, Yang Yang, Oisun Jung, DeannaLee M. Beauvais

Bone marrow aspirates from 12 individual patients were incubated on Sdc1 antibody to capture CD138+ myeloma cells and exclude other cell types present in the aspirates. Captured cells were fixed and stained for αvβ3 (LM609), αvβ5 (P1F6), or IGF1R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::153d4387a5d9c82110977221974d0efc
https://doi.org/10.1158/0008-5472.22411515.v1

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SUPPLEMENTARY FIGURE 2. SSTN inhibition of IGF1R in myeloma inhibits adhesion-independent cell survival. from Syndecan-1 (CD138) Suppresses Apoptosis in Multiple Myeloma by Activating IGF1 Receptor: Prevention by SynstatinIGF1R Inhibits Tumor Growth

Autor: Alan C. Rapraeger, Ralph D. Sanderson, Yang Yang, Oisun Jung, DeannaLee M. Beauvais

A. CAG cells are plated for 2 hr on VN or FN in the presence or absence of 10 μg/mL VLA-4 (P1H4) or 30 μg/mL αvβ5 (P1F6) integrin blocking antibodies; B. CAG myeloma cells grown for 72 hr in the presence of 10 μg/mL VLA-4 (P1H4) or 30 μg/mL αv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::256e281373cafa02a12d096b816e5350
https://doi.org/10.1158/0008-5472.22411512

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Plasma membrane proteoglycans syndecan-2 and syndecan-4 engage with EGFR and RON kinase to sustain carcinoma cell cycle progression

Autor: DeannaLee M. Beauvais, Scott E. Nelson, Kristin M. Adams, Noah A. Stueven, Oisun Jung, Alan C. Rapraeger

Publikováno v: The Journal of biological chemistry. 298(6)

Epidermal growth factor receptor (EGFR) is a causal factor in carcinoma, yet many carcinoma patients are resistant to EGFR inhibitors. Potential insight into this resistance stems from prior work that showed EGFR in normal epithelial cells docks to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd6a4cd213b83310cb27b6d6ef74b9a6
https://pubmed.ncbi.nlm.nih.gov/35569509

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Matrix Interactions of Cell Surface Proteoglycans

Autor: Joy E. Koda, Alan C. Rapraeger, Merton Bernfield

Publikováno v: Connective Tissue Disease ISBN: 9781003210016

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35312d67645ea134265c27ec1d5b0bcf
https://doi.org/10.1201/9781003210016-11

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The Specificity of EGF-Stimulated IQGAP1 Scaffold Towards the PI3K-Akt Pathway is Defined by the IQ3 motif

Autor: Suyong Choi, Oisun Jung, Christina Baum, Mo Chen, Tianmu Wen, Richard A. Anderson, Paul F. Lambert, Narendra Thapa, Alan C. Rapraeger

Publikováno v: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)

Epidermal growth factor receptor (EGFR) and its downstream phosphoinositide 3-kinase (PI3K) pathway are commonly deregulated in cancer. Recently, we have shown that the IQ motif-containing GTPase-activating protein 1 (IQGAP1) provides a molecular pla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbcf9c173a20ae392a9e49b8b5f1c146
http://europepmc.org/articles/PMC6591252

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