Zobrazeno 1 - 10
of 459
pro vyhledávání: '"A C, Pavlick"'
Autor:
Michael J. Dennis, Dean C. Pavlick, Alec Kacew, Michael Wotman, Laura E. MacConaill, Stephanie M. Jones, Kathleen L. Pfaff, Scott J. Rodig, Stephen Eacker, Maika Malig, Emily Reister, David Piccioni, Santosh Kesari, Kartik Sehgal, Robert I. Haddad, Ezra Cohen, Marshall R. Posner, Ida Deichaite, Glenn J. Hanna
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background Brain metastasis (BM) is a rare but severe complication of head and neck squamous cell carcinoma (HNSCC), with limited knowledge of molecular characteristics and immunogenicity. Methods We analyzed 61 cases of HNSCC-BM from three
Externí odkaz:
https://doaj.org/article/c494f43336d14d3082d8e50a20f138b9
Autor:
Jie He, David Fabrizio, Jonathan Baden, Parul Doshi, James Pratt, Lee A Albacker, Geoffrey R Oxnard, Gina Fusaro, Natallia Kalinava, Dean C Pavlick, Ericka M Ebot, Hanna Tukachinsky, George Green
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 11 (2023)
Background An accumulation of somatic mutations in tumors leads to increased neoantigen levels and antitumor immune response. Tumor mutational burden (TMB) reflects the rate of somatic mutations in the tumor genome, as determined from tumor tissue (t
Externí odkaz:
https://doaj.org/article/67f683c42d324745bba4fb1c1790f1d3
Autor:
Omid Hamid, Diwakar Davar, Keisuke Shirai, Benjamin Izar, Charlotte E Ariyan, Michael K Wong, Jason J Luke, Janis M Taube, Anna C Pavlick, Meghan J Mooradian, Douglas B Johnson, Hussein A Tawbi, Tara C Mitchell, Ryan J Sullivan, April KS Salama, Krista M Rubin, Elizabeth I Buchbinder, Sarah A Weiss, Tina J Hieken, Geoffrey T Gibney, Rajan P Kulkarni, J Keith Tolley, Caressa Valdueza
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 10 (2023)
Since the first approval for immune checkpoint inhibitors (ICIs) for the treatment of cutaneous melanoma more than a decade ago, immunotherapy has completely transformed the treatment landscape of this chemotherapy-resistant disease. Combination regi
Externí odkaz:
https://doaj.org/article/f4721e0504094c6083b6710589696855
Publikováno v:
Российский офтальмологический журнал, Vol 15, Iss 1, Pp 122-127 (2022)
Purpose. To describe two ipsilateral, metachronous, ocular choroidal melanoma metastases.Material and methods. A 64-year-old choroidal melanoma patient was initially treated with palladium-103 ophthalmic plaque brachytherapy which induced local contr
Externí odkaz:
https://doaj.org/article/f811cf012e7543ec81341f81bdfc33ac
Autor:
Chien-Yu Lin, Sheng-Huan Wei, Yi-Lin Chen, Chung-Ta Lee, Shang-Yin Wu, Chung-Liang Ho, Dean C. Pavlick, Po-Lan Su, Chien-Chung Lin
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Telisotuzumab vedotin is a MET-targeting antibody–drug conjugate that has demonstrated a good treatment response in patients with EGFR wild-type MET-overexpressing non-squamous non-small cell lung cancer. However, patients have been reported to acq
Externí odkaz:
https://doaj.org/article/c5d82a14666246079097088647b395c1
Autor:
Christopher A Barker, Evan J Lipson, Harriet Kluger, Brian R Gastman, Michael T Tetzlaff, Igor Puzanov, Shailender Bhatia, Paul Nghiem, Ann W Silk, Zeynep Eroglu, Sunandana Chandra, Isaac Brownell, Anna C Pavlick, David M Miller, Vernon K Sondak, Kari L Kendra, Kathryn B Bollin, Kathleen Madden, Guilherme Rabinowits, Emily S Ruiz, Edward A Tavss
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 7 (2022)
Nonmelanoma skin cancers (NMSCs) are some of the most commonly diagnosed malignancies. In general, early-stage NMSCs have favorable outcomes; however, a small subset of patients develop resistant, advanced, or metastatic disease, or aggressive subtyp
Externí odkaz:
https://doaj.org/article/2231699fe22649279195857fb8881112
Autor:
Zhenfang Du, Benjamin P. Brown, Soyeon Kim, Donna Ferguson, Dean C. Pavlick, Gowtham Jayakumaran, Ryma Benayed, Jean-Nicolas Gallant, Yun-Kai Zhang, Yingjun Yan, Monica Red-Brewer, Siraj M. Ali, Alexa B. Schrock, Ahmet Zehir, Marc Ladanyi, Adam W. Smith, Jens Meiler, Christine M. Lovly
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
An EGFR mutant with kinase domain duplication (EGFR-KDD) was previously identified in an index patient, but the functional and therapeutic implications remain unclear. Here, the authors show that KDD occurs in other ErbB receptors in multiple cancers
Externí odkaz:
https://doaj.org/article/b948db7f0a2649d5908bbadfe529545e
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BRAF fusions are rare driver oncogenes in non-small cell lung cancer (NSCLC). Similar with BRAF V600E mutation, it could also activate the MAPK signaling pathway. There are a few case reports which had indicated the potential response to BRAF inhibit
Externí odkaz:
https://doaj.org/article/21c1ff32245b4559ad40e5ea9d66889c
Autor:
Coren A. Milbury, James Creeden, Wai-Ki Yip, David L. Smith, Varun Pattani, Kristi Maxwell, Bethany Sawchyn, Ole Gjoerup, Wei Meng, Joel Skoletsky, Alvin D. Concepcion, Yanhua Tang, Xiaobo Bai, Ninad Dewal, Pei Ma, Shannon T. Bailey, James Thornton, Dean C. Pavlick, Garrett M. Frampton, Daniel Lieber, Jared White, Christine Burns, Christine Vietz
Publikováno v:
PLoS ONE, Vol 17, Iss 3 (2022)
FoundationOne®CDx (F1CDx) is a United States (US) Food and Drug Administration (FDA)-approved companion diagnostic test to identify patients who may benefit from treatment in accordance with the approved therapeutic product labeling for 28 drug ther
Externí odkaz:
https://doaj.org/article/c077dd424a014a30b87dd38f621e7d50
Autor:
Guilherme Rabinowits, Michael R. Migden, Todd E. Schlesinger, Robert L. Ferris, Morganna Freeman, Valerie Guild, Shlomo Koyfman, Anna C. Pavlick, Neil Swanson, Gregory T. Wolf, Scott M. Dinehart
Publikováno v:
JID Innovations, Vol 1, Iss 4, Pp 100045- (2021)
Cutaneous squamous cell carcinoma is the second most common skin cancer in the United States. Currently, there is no standardized management approach for patients with cutaneous squamous cell carcinoma who develop metastatic or locally advanced disea
Externí odkaz:
https://doaj.org/article/7bfa396119cd430f85368f3066722ea1