Zobrazeno 1 - 10
of 598
pro vyhledávání: '"A C, Pahl"'
Autor:
Matthew C Pahl, Prabhat Sharma, Rajan M Thomas, Zachary Thompson, Zachary Mount, James A Pippin, Peter A Morawski, Peng Sun, Chun Su, Daniel Campbell, Struan FA Grant, Andrew D Wells
Publikováno v:
eLife, Vol 13 (2024)
Genome-wide association studies (GWAS) have identified hundreds of genetic signals associated with autoimmune disease. The majority of these signals are located in non-coding regions and likely impact cis-regulatory elements (cRE). Because cRE functi
Externí odkaz:
https://doaj.org/article/48b8e3b4f93d4805a83e4df3a71693d2
Autor:
Rajan M Thomas, Matthew C Pahl, Liqing Wang, Struan FA Grant, Wayne W Hancock, Andrew D Wells
Publikováno v:
eLife, Vol 12 (2024)
Ikaros is a transcriptional factor required for conventional T cell development, differentiation, and anergy. While the related factors Helios and Eos have defined roles in regulatory T cells (Treg), a role for Ikaros has not been established. To det
Externí odkaz:
https://doaj.org/article/ba76a93665e24702a7a850571913d233
Autor:
Chaojie Yang, Jenna Veenstra, Traci M. Bartz, Matthew C. Pahl, Brian Hallmark, Yii-Der Ida Chen, Jason Westra, Lyn M. Steffen, Christopher D. Brown, David Siscovick, Michael Y. Tsai, Alexis C. Wood, Stephen S. Rich, Caren E. Smith, Timothy D. O’Connor, Dariush Mozaffarian, Struan F. A. Grant, Floyd H. Chilton, Nathan L. Tintle, Rozenn N. Lemaitre, Ani Manichaikul
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Abstract Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) play critical roles in human health. Prior genome-wide association studies (GWAS) of n-3 and n-6 PUFAs in European Americans from the CHARGE Consortium have documented stron
Externí odkaz:
https://doaj.org/article/ddf869699ad642f1a57ef3ec28d71404
Autor:
Matthew C. Pahl, Lin Liu, James A. Pippin, Yadav Wagley, Keith Boehm, Kurt D. Hankenson, Andrew D. Wells, Wenli Yang, Struan F.A. Grant
Publikováno v:
EBioMedicine, Vol 101, Iss , Pp 105038- (2024)
Summary: Background: Carpal tunnel syndrome (CTS) is a common disorder caused by compression of the median nerve in the wrist, resulting in pain and numbness throughout the hand and forearm. While multiple behavioural and physiological factors influe
Externí odkaz:
https://doaj.org/article/936e1d8008fc4156b7c5db74b867d0b6
Autor:
Matthew C. Pahl, Carole Le Coz, Chun Su, Prabhat Sharma, Rajan M. Thomas, James A. Pippin, Emylette Cruz Cabrera, Matthew E. Johnson, Michelle E. Leonard, Sumei Lu, Alessandra Chesi, Kathleen E. Sullivan, Neil Romberg, Struan F. A. Grant, Andrew D. Wells
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-19 (2022)
Abstract Background SARS-CoV-2 infection results in a broad spectrum of COVID-19 disease, from mild or no symptoms to hospitalization and death. COVID-19 disease severity has been associated with some pre-existing conditions and the magnitude of the
Externí odkaz:
https://doaj.org/article/8df9b6167b7e4c4c861156596c1735c6
Autor:
Cameron C. Pahl, Luis A. Ruedas
Publikováno v:
PLoS ONE, Vol 18, Iss 11 (2023)
Externí odkaz:
https://doaj.org/article/8bae808de5124b11acc4779cdf054f04
Autor:
Matthew C. Pahl, Claudia A. Doege, Kenyaita M. Hodge, Sheridan H. Littleton, Michelle E. Leonard, Sumei Lu, Rick Rausch, James A. Pippin, Maria Caterina De Rosa, Alisha Basak, Jonathan P. Bradfield, Reza K. Hammond, Keith Boehm, Robert I. Berkowitz, Chiara Lasconi, Chun Su, Alessandra Chesi, Matthew E. Johnson, Andrew D. Wells, Benjamin F. Voight, Rudolph L. Leibel, Diana L. Cousminer, Struan F. A. Grant
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Understanding the genetic regulation of hypothalamic function could yield insights into disease pathogenesis, but its inaccessibility has made this challenging. Here the authors present a high-resolution chromatin atlas of a hypothalamic-like neuron
Externí odkaz:
https://doaj.org/article/87b561b18c73423d8f4af95c3968229a
Autor:
Diana L. Cousminer, Yadav Wagley, James A. Pippin, Ahmed Elhakeem, Gregory P. Way, Matthew C. Pahl, Shana E. McCormack, Alessandra Chesi, Jonathan A. Mitchell, Joseph M. Kindler, Denis Baird, April Hartley, Laura Howe, Heidi J. Kalkwarf, Joan M. Lappe, Sumei Lu, Michelle E. Leonard, Matthew E. Johnson, Hakon Hakonarson, Vicente Gilsanz, John A. Shepherd, Sharon E. Oberfield, Casey S. Greene, Andrea Kelly, Deborah A. Lawlor, Benjamin F. Voight, Andrew D. Wells, Babette S. Zemel, Kurt D. Hankenson, Struan F. A. Grant
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-32 (2021)
Abstract Background Bone accrual impacts lifelong skeletal health, but genetic discovery has been primarily limited to cross-sectional study designs and hampered by uncertainty about target effector genes. Here, we capture this dynamic phenotype by m
Externí odkaz:
https://doaj.org/article/165481b925744dddb170926499acd9cc
Autor:
Chiara Lasconi, Matthew C. Pahl, Diana L. Cousminer, Claudia A. Doege, Alessandra Chesi, Kenyaita M. Hodge, Michelle E. Leonard, Sumei Lu, Matthew E. Johnson, Chun Su, Reza K. Hammond, James A. Pippin, Natalie A. Terry, Louis R. Ghanem, Rudolph L. Leibel, Andrew D. Wells, Struan F.A. Grant
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 3, Pp 667-682 (2021)
Background & Aims: Inflammatory bowel disease (IBD) is a polygenic disorder characterized principally by dysregulated inflammation impacting the gastrointestinal tract. However, there also is increasing evidence for a clinical association with stress
Externí odkaz:
https://doaj.org/article/5ea732da22e64125aa7a08b992a12fda
Autor:
James A Pippin, Alessandra Chesi, Yadav Wagley, Chun Su, Matthew C Pahl, Kenyaita M Hodge, Matthew E Johnson, Andrew D Wells, Kurt D Hankenson, Struan F A Grant
Publikováno v:
JBMR Plus, Vol 5, Iss 9, Pp n/a-n/a (2021)
ABSTRACT Genome‐wide–association studies (GWASs) have discovered genetic signals robustly associated with BMD, but typically not the precise localization of effector genes. By intersecting genome‐wide promoter‐focused Capture C and assay for
Externí odkaz:
https://doaj.org/article/d08a24cbe2ab499ea2c8c4737f67ce68