Zobrazeno 1 - 10
of 205
pro vyhledávání: '"A C, Nathwani"'
Autor:
Mark A. Brimble, Pei-Hsin Cheng, Stephen M. Winston, Isaiah L. Reeves, Aisha Souquette, Yunyu Spence, Junfang Zhou, Yong-Dong Wang, Christopher L. Morton, Marcus Valentine, Paul G. Thomas, Amit C. Nathwani, John T. Gray, Andrew M. Davidoff
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 24, Iss , Pp 280-291 (2022)
Recombinant adeno-associated virus (rAAV) vectors are increasingly being used for clinical gene transfer and have shown great potential for the treatment of several monogenic disorders. However, contaminant DNA from producer plasmids can be packaged
Externí odkaz:
https://doaj.org/article/9ce90bd19a374a6086d2a19259d8a399
Publikováno v:
Human Gene Therapy. 33:879-888
Gene therapy is an exciting therapeutic concept that offers the promise of a cure for an array of inherited and acquired disorders. The liver has always been a key target for gene therapy as it controls essential biological processes including digest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abe0b0c1468d167ebed270cd086b470b
https://doi.org/10.1089/hum.2022.169
https://doi.org/10.1089/hum.2022.169
Autor:
Andrew M. Davidoff, Taosheng Chen, R. Kiplin Guy, Stephen White, Douglas R. Green, Junmin Peng, Chunxu Qu, Yong Cheng, Ashutosh Mishra, Jie J. Zheng, Zhenmei Li, Yinan Wu, Anang Shelat, Sourav Das, Brandon Young, Vincent A. Boyd, Su Sien Ong, Yingdi Wang, Ruoning Wang, Amit C. Nathwani, Pollyanna Goh, Ju Bao, Wenwei Lin, Jonathan Low, Jesse Davidson, Junfang Zhou, Rodrigo B. Interiano, Alaa M. AlTahan, Dongli Hu, Sandra Milasta, Jun Yang
Histone lysine demethylases facilitate the activity of oncogenic transcription factors, including possibly MYC. Here we show that multiple histone demethylases influence the viability and poor prognosis of neuroblastoma cells, where MYC is often over
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e96065cdcf2a58b228dbe3422f2dd09
https://doi.org/10.1158/0008-5472.c.6508916
https://doi.org/10.1158/0008-5472.c.6508916
Autor:
Andrew M. Davidoff, Taosheng Chen, R. Kiplin Guy, Stephen White, Douglas R. Green, Junmin Peng, Chunxu Qu, Yong Cheng, Ashutosh Mishra, Jie J. Zheng, Zhenmei Li, Yinan Wu, Anang Shelat, Sourav Das, Brandon Young, Vincent A. Boyd, Su Sien Ong, Yingdi Wang, Ruoning Wang, Amit C. Nathwani, Pollyanna Goh, Ju Bao, Wenwei Lin, Jonathan Low, Jesse Davidson, Junfang Zhou, Rodrigo B. Interiano, Alaa M. AlTahan, Dongli Hu, Sandra Milasta, Jun Yang
Figure S1 shows siRNA screening in neuroblastoma cells. Figure S2 shows the dentification of ciclopirox that targets KDM4B. Figure S3 shows the CPX effect on other histone methyl marks. Figure S4 shows that CPX targets the Myc pathway. Figure S5 show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c093311ea8c98a81adeb8b227cbaf3d
https://doi.org/10.1158/0008-5472.22414205
https://doi.org/10.1158/0008-5472.22414205
Publikováno v:
Cells, Vol 9, Iss 11, p 2474 (2020)
We have previously used a hepatotropic adeno-associated viral (AAV) vector with a modified human insulin gene to treat diabetic mice. The HLP (hybrid liver-specific promoter) used was constitutively active and non-responsive to glucose. In this study
Externí odkaz:
https://doaj.org/article/36140b25fe8f4692a27038cb298e2d6a
Autor:
Ellis J. Neufeld, Nickhill Bhakta, Nancy S. Bolous, Andrew M. Davidoff, Ulrike M. Reiss, Huiqi Wang, Carlos Rodriguez-Galindo, Amit C. Nathwani, Meenakshi Devidas, Michael M Meagher, Bryan A. Piras, Timothy W. Jacobs, Yichen Chen
Publikováno v:
Blood. 138:1677-1690
Adeno-associated virus (AAV)-mediated gene therapy is a novel treatment promising to reduce morbidity associated with hemophilia. Although multiple clinical trials continue to evaluate efficacy and safety, limited cost-effectiveness data have been pu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::614fba9b6e9970ba78c81a19a59f45d8
https://doi.org/10.1182/blood.2021010864
https://doi.org/10.1182/blood.2021010864
Autor:
Jonathan H. Foley, Erald Shehu, Anne Riddell, Elaine Gray, Andrew Goodale, I-Mei Yu, Daniël Verhoef, John Little, Diane Shattock, Steve Kitchen, Pratima Chowdary, Romuald Corbau, Amit C. Nathwani
Publikováno v:
Blood advances.
Adeno-associated virus (AAV) gene therapy has the potential to functionally cure hemophilia B by restoring factor (F)IX concentrations into the normal range. Next-generation AAV therapies express a naturally occurring gain-of-function FIX variant, FI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef828a6167768afc706cdf480a5ec2c0
https://pubmed.ncbi.nlm.nih.gov/35839077
https://pubmed.ncbi.nlm.nih.gov/35839077
Autor:
Adrian Bloor, Anna Hockaday, Amit C. Nathwani, David Allsup, Peter Hillmen, Andy C. Rawstron, Talha Munir, Dena R. Howard, Shankara Paneesha, Jamie B. Oughton, David Phillips, Jake Emmerson, Deborah Turner
Publikováno v:
British Journal of Haematology. 194:646-650
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::353da9ccdd0048d06aa4d84f04488d1b
https://doi.org/10.1111/bjh.17526
https://doi.org/10.1111/bjh.17526
Autor:
Albert J. R. Heck, Joanna R. Long, Terry R. Flotte, Maria Söderlund-Venermo, James M. Wilson, Jay Chiorini, Arun Srivastava, Dirk Grimm, Sawati Chatterjee, William W. Hauswirth, Guangping Gao, Robert Michael Kotin, Pat Ritschel, Ian E. Alexander, Joost Snijder, Amit C. Nathwani, Regine Heilbronn, Leszek Lisowski, Junghae Suh, Richard Snyder, Peter Tattersall, Dmitry Lyumkis, Juergen Dr Kleinschmidt, Michael Chapman, Colin R. Parrish, Aravind Asokan, José M. Almendral, Susan F. Cotmore, Grant J Logan, Kenneth Ira Berns
Publikováno v:
Human Gene Therapy. 32:321-326
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be6fcd52d390bb4fdec67ec23bb4ada
https://doi.org/10.1089/hum.2021.29158.mam
https://doi.org/10.1089/hum.2021.29158.mam
Autor:
David Granger, Patricia Henne, Annalisa Baccaro, Dinusha Fernando, Jasmine Gore, Ephraim Gbajumo, Vincent Muczynski, Mittal Shah, Kieran O'Donovan, Kerry Chester, Amit C. Nathwani
Publikováno v:
Blood. 140:7810-7811
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7857612fc23211333a899c33a54db0f
https://doi.org/10.1182/blood-2022-168961
https://doi.org/10.1182/blood-2022-168961