Zobrazeno 1 - 10
of 711
pro vyhledávání: '"A C, Nairn"'
Autor:
Simon J. Pelletier, Mickaël Leclercq, Florence Roux-Dalvai, Matthijs B. de Geus, Shannon Leslie, Weiwei Wang, TuKiet T. Lam, Angus C. Nairn, Steven E. Arnold, Becky C. Carlyle, Frédéric Precioso, Arnaud Droit
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Liquid Chromatography Mass Spectrometry (LC-MS) is a powerful method for profiling complex biological samples. However, batch effects typically arise from differences in sample processing protocols, experimental conditions, and data acquisit
Externí odkaz:
https://doaj.org/article/f411488984d94091a9e476c56116f06f
Autor:
Matthijs B. de Geus, Shannon N. Leslie, TuKiet Lam, Weiwei Wang, Florence Roux-Dalvai, Arnaud Droit, Pia Kivisakk, Angus C. Nairn, Steven E. Arnold, Becky C. Carlyle
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Alzheimer’s disease (AD) is a complex and heterogeneous neurodegenerative disorder with contributions from multiple pathophysiological pathways. One of the long-recognized and important features of AD is disrupted cerebral glucose metaboli
Externí odkaz:
https://doaj.org/article/3a59c8e75fa246d69d39653983e8997b
Autor:
Valeria Lallai, TuKiet T. Lam, Rolando Garcia-Milian, Yen-Chu Chen, James P. Fowler, Letizia Manca, Daniele Piomelli, Kenneth Williams, Angus C. Nairn, Christie D. Fowler
Publikováno v:
Biomolecules, Vol 14, Iss 9, p 1143 (2024)
Given the increasing use of cannabis in the US, there is an urgent need to better understand the drug’s effects on central signaling mechanisms. Extracellular vesicles (EVs) have been identified as intercellular signaling mediators that contain a v
Externí odkaz:
https://doaj.org/article/8a5e8ff0fc664decb38c759a33e11e57
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-6 (2023)
Abstract Recent technological advances have opened the door to single-cell proteomics that can answer key biological questions regarding how protein expression, post-translational modifications, and protein interactions dictate cell state in health a
Externí odkaz:
https://doaj.org/article/7950f11c69a14e6ca417ecafbbc9e6b1
Autor:
Shveta Bathla, Dibyadeep Datta, Feng Liang, Nicolas Barthelemy, Robyn Wiseman, Barbara S Slusher, Jennifer Asher, Caroline Zeiss, Dil Ekanayake‐Alper, Daniel Holden, Gordon Terwilliger, Alvaro Duque, Jon Arellano, Christopher van Dyck, Randall J. Bateman, Zhongcong Xie, Angus C. Nairn, Amy F. T. Arnsten
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 9, Iss 4, Pp n/a-n/a (2023)
Abstract Introduction Current approaches for treating sporadic Alzheimer's disease (sAD) focus on removal of amyloid beta 1‐42 (Aβ1‐42) or phosphorylated tau, but additional strategies are needed to reduce neuropathology at earlier stages prior
Externí odkaz:
https://doaj.org/article/4a8ad01a575e469c98877796355ff4db
Autor:
Mònica Pardo, Sara Gregorio, Enrica Montalban, Lluís Pujadas, Alba Elias-Tersa, Núria Masachs, Alba Vílchez-Acosta, Annabelle Parent, Carme Auladell, Jean-Antoine Girault, Miquel Vila, Angus C. Nairn, Yasmina Manso, Eduardo Soriano
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
In addition to neuronal migration, brain development, and adult plasticity, the extracellular matrix protein Reelin has been extensively implicated in human psychiatric disorders such as schizophrenia, bipolar disorder, and autism spectrum disorder.
Externí odkaz:
https://doaj.org/article/3cd3106052264619a64208bc8946f830
Autor:
Karl Foley, Haider Altimimi, Hailong Hou, Yu Zhang, Cody McKee, Makaía M. Papasergi-Scott, Hongtian Yang, Abigail Mayer, Nancy Ward, David M. MacLean, Angus C. Nairn, David Stellwagen, Houhui Xia
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 14 (2022)
Inhibitor-2 (I-2) is a prototypic inhibitor of protein phosphatase-1 (PP1), a major serine-threonine phosphatase that regulates synaptic plasticity and learning and memory. Although I-2 is a potent inhibitor of PP1 in vitro, our previous work has elu
Externí odkaz:
https://doaj.org/article/c086457f6f344661aadfe21d54e67f5d
Publikováno v:
Canadian Journal for the Scholarship of Teaching and Learning, Vol 11, Iss 3, Pp 1-15 (2020)
Past research on face-to-face instructional delivery demonstrates that students’ participation is positively related to their achievement in a course (Rocca, 2010), and that participation mediates the relation between attendance and achievement (Ki
Externí odkaz:
https://doaj.org/article/3e63825eb9044298a6c75d838ed4511b
Autor:
Avery D. Franzen, Tukiet T. Lam, Kenneth R. Williams, Angus C. Nairn, Ronald S. Duman, Monica Sathyanesan, Vikas Kumar, Linda L. Carpenter, Samuel S. Newton
Publikováno v:
BMC Psychiatry, Vol 20, Iss 1, Pp 1-12 (2020)
Abstract Background Depression affects approximately 7.1% of the United States population every year and has an annual economic burden of over $210 billion dollars. Several recent studies have sought to investigate the pathophysiology of depression u
Externí odkaz:
https://doaj.org/article/a114c8eade1c4e04a18a234e204ff3ee
Autor:
Dibyadeep Datta, Shannon N. Leslie, Yury M. Morozov, Alvaro Duque, Pasko Rakic, Christopher H. van Dyck, Angus C. Nairn, Amy F. T. Arnsten
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-15 (2020)
Abstract Background Cognitive impairment in schizophrenia, aging, and Alzheimer’s disease is associated with spine and synapse loss from the dorsolateral prefrontal cortex (dlPFC) layer III. Complement cascade signaling is critical in driving spine
Externí odkaz:
https://doaj.org/article/41ffea11f85e4da3bb94c0f905d4c13b