Zobrazeno 1 - 10
of 217
pro vyhledávání: '"A C, Looker"'
Autor:
Joseph J. Shearer, Maryam Hashemian, Robert G. Nelson, Helen C. Looker, Alanna M. Chamberlain, Tiffany M. Powell-Wiley, Eliseo J. Pérez-Stable, Véronique L. Roger
Publikováno v:
PLoS ONE, Vol 19, Iss 5 (2024)
Externí odkaz:
https://doaj.org/article/ef47392e1024417fbb98a47712e80926
Autor:
Kumar Sharma, Guanshi Zhang, Jens Hansen, Petter Bjornstad, Hak Joo Lee, Rajasree Menon, Leila Hejazi, Jian-Jun Liu, Anthony Franzone, Helen C. Looker, Byeong Yeob Choi, Roman Fernandez, Manjeri A. Venkatachalam, Luxcia Kugathasan, Vikas S. Sridhar, Loki Natarajan, Jing Zhang, Varun S. Sharma, Brian Kwan, Sushrut S. Waikar, Jonathan Himmelfarb, Katherine R. Tuttle, Bryan Kestenbaum, Tobias Fuhrer, Harold I. Feldman, Ian H. de Boer, Fabio C. Tucci, John Sedor, Hiddo Lambers Heerspink, Jennifer Schaub, Edgar A. Otto, Jeffrey B. Hodgin, Matthias Kretzler, Christopher R. Anderton, Theodore Alexandrov, David Cherney, Su Chi Lim, Robert G. Nelson, Jonathan Gelfond, Ravi Iyengar, for the Kidney Precision Medicine Project
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 20 (2023)
Diabetic kidney disease (DKD) can lead to end-stage kidney disease (ESKD) and mortality; however, few mechanistic biomarkers are available for high-risk patients, especially those without macroalbuminuria. Urine from participants with diabetes from t
Externí odkaz:
https://doaj.org/article/15a3cc7202a34114a72f51162fa19310
Autor:
Laura J. Smyth, Emma H. Dahlström, Anna Syreeni, Katie Kerr, Jill Kilner, Ross Doyle, Eoin Brennan, Viji Nair, Damian Fermin, Robert G. Nelson, Helen C. Looker, Christopher Wooster, Darrell Andrews, Kerry Anderson, Gareth J. McKay, Joanne B. Cole, Rany M. Salem, Peter J. Conlon, Matthias Kretzler, Joel N. Hirschhorn, Denise Sadlier, Catherine Godson, Jose C. Florez, GENIE consortium, Carol Forsblom, Alexander P. Maxwell, Per-Henrik Groop, Niina Sandholm, Amy Jayne McKnight
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Approximately 40 percent of people with type 1 diabetes develop kidney disease, but the risk factors are not well understood. Here, the authors identify DNA methylation signatures associated with diabetic kidney disease, of which 21 biomarkers predic
Externí odkaz:
https://doaj.org/article/777a9666411244d6bce4bb7f84d0b5c3
Autor:
Farsad Afshinnia, Evan L. Reynolds, Thekkelnaycke M. Rajendiran, Tanu Soni, Jaeman Byun, Masha G. Savelieff, Helen C. Looker, Robert G. Nelson, George Michailidis, Brian C. Callaghan, Subramaniam Pennathur, Eva L. Feldman
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 9, Iss 9, Pp 1392-1404 (2022)
Abstract Objective The serum lipidomic profile associated with neuropathy in type 2 diabetes is not well understood. Obesity and dyslipidemia are known neuropathy risk factors, suggesting lipid profiles early during type 2 diabetes may identify indiv
Externí odkaz:
https://doaj.org/article/d318044b851d4b8d8d34b931e9b4f96b
Autor:
Evan L. Reynolds, Gulcin Akinci, Mousumi Banerjee, Helen C. Looker, Adam Patterson, Robert G. Nelson, Eva L. Feldman, Brian C. Callaghan
Publikováno v:
JCI Insight, Vol 8, Iss 3 (2023)
Externí odkaz:
https://doaj.org/article/da1afe50f10d4ba39e9148e2ab94036c
Autor:
Mark L. Unruh, Soraya Arzhan, Harold I. Feldman, Helen C. Looker, Robert G. Nelson, Thomas Faber, David Johnson, Linda Son-Stone, Vernon S. Pankratz, Larissa Myaskovsky, Vallabh O. Shah, the CRIC study investigators
Publikováno v:
BMC Nephrology, Vol 21, Iss 1, Pp 1-11 (2020)
Abstract Background Chronic kidney disease (CKD) is an increasing epidemic globally that is associated with adverse health outcomes including end stage kidney disease (ESKD), cardiovascular disease (CVD), and death. American Indians (AIs) have a high
Externí odkaz:
https://doaj.org/article/f47acec2a5c4477fbf1cc07c1f3b1c13
Autor:
Patrice E. Fort, Thekkelnaycke M. Rajendiran, Tanu Soni, Jaeman Byun, Yang Shan, Helen C. Looker, Robert G. Nelson, Matthias Kretzler, George Michailidis, Jerome E. Roger, Thomas W. Gardner, Steven F. Abcouwer, Subramaniam Pennathur, Farsad Afshinnia
Publikováno v:
JCI Insight, Vol 6, Iss 19 (2021)
BACKGROUND This study systematically investigated circulating and retinal tissue lipid determinants of human diabetic retinopathy (DR) to identify underlying lipid alterations associated with severity of DR.METHODS Retinal tissues were retrieved from
Externí odkaz:
https://doaj.org/article/dbaa7f52a5e1422898c64c6489cc2f2b
Autor:
Evan L. Reynolds, Gulcin Akinci, Mousumi Banerjee, Helen C. Looker, Adam Patterson, Robert G. Nelson, Eva L. Feldman, Brian C. Callaghan
Publikováno v:
JCI Insight, Vol 6, Iss 10 (2021)
BACKGROUND We aimed to determine whether metabolic syndrome (MetS) affects longitudinal trajectories of diabetic complications, including neuropathy, cardiovascular autonomic neuropathy (CAN), and kidney disease in American Indians with type 2 diabet
Externí odkaz:
https://doaj.org/article/eea820c707c64febb7e7be7cca7c6677
Autor:
Shaween Al-Talabany, Ify Mordi, J. Graeme Houston, Helen M. Colhoun, Jonathan R. Weir-McCall, Shona Z. Matthew, Helen C. Looker, Daniel Levin, Jill J. F. Belch, Fiona Dove, Faisel Khan, Chim C. Lang
Publikováno v:
BMC Cardiovascular Disorders, Vol 18, Iss 1, Pp 1-8 (2018)
Abstract Background Epicardial adipose tissue (EAT) is an emerging cardio-metabolic risk factor and has been shown to correlate with adverse cardiovascular (CV) outcome; however the underlying pathophysiology of this link is not well understood. The
Externí odkaz:
https://doaj.org/article/e5ad439aea454f3e92d284483ef7c099
Autor:
F. Casanova, D. D. Adingupu, F. Adams, K. M. Gooding, H. C. Looker, K. Aizawa, F. Dove, S. Elyas, J. J. F. Belch, P. E. Gates, R. C. Littleford, M. Gilchrist, H. M. Colhoun, A. C. Shore, F. Khan, W. D. Strain
Publikováno v:
Cardiovascular Diabetology, Vol 16, Iss 1, Pp 1-11 (2017)
Abstract Background Good glycaemic control in type 2 diabetes (T2DM) protects the microcirculation. Current guidelines suggest glycaemic targets be relaxed in advanced diabetes. We explored whether disease duration or pre-existing macrovascular compl
Externí odkaz:
https://doaj.org/article/fa3ba5c4c84d4c1aa8248f75dd5ba348