Zobrazeno 1 - 10
of 94
pro vyhledávání: '"A C, Houtman"'
Autor:
J. J. A. van Bavel, C. Pham, H. D. M. Beekman, M. J. C. Houtman, A. Bossu, R. W. Sparidans, M. A. G. van der Heyden, M. A. Vos
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
BackgroundThe phosphoinositide 3-kinase (PI3K) signaling pathway is an interesting target in cancer treatment. The awareness of the proarrhythmic risk of PI3K inhibitors was raised because PI3K is also involved in regulating signaling toward cardiac
Externí odkaz:
https://doaj.org/article/babebe5088204972a6e5d4822409d2e5
Autor:
Muhammad Furqan, Taher Abu-Hejleh, Laura M. Stephens, Stacey M. Hartwig, Sarah L. Mott, Casey F. Pulliam, Michael Petronek, John B. Henrich, Melissa A. Fath, Jon C. Houtman, Steven M. Varga, Kellie L. Bodeker, Aaron D. Bossler, Andrew M. Bellizzi, Jun Zhang, Varun Monga, Hariharasudan Mani, Marina Ivanovic, Brian J. Smith, Margaret M. Byrne, William Zeitler, Brett A. Wagner, Garry R. Buettner, Joseph J. Cullen, John M. Buatti, Douglas R. Spitz, Bryan G. Allen
Publikováno v:
Redox Biology, Vol 53, Iss , Pp 102318- (2022)
Purpose: Platinum-based chemotherapy with or without immunotherapy is the mainstay of treatment for advanced stage non-small cell lung cancer (NSCLC) lacking a molecular driver alteration. Pre-clinical studies have reported that pharmacological ascor
Externí odkaz:
https://doaj.org/article/3029ad560b984a928c853c72d0650fca
Autor:
Marien J. C. Houtman, Theres Friesacher, Xingyu Chen, Eva-Maria Zangerl-Plessl, Marcel A. G. van der Heyden, Anna Stary-Weinzinger
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
Introduction: DEND syndrome is a rare channelopathy characterized by a combination of developmental delay, epilepsy and severe neonatal diabetes. Gain of function mutations in the KCNJ11 gene, encoding the KIR6.2 subunit of the IKATP potassium channe
Externí odkaz:
https://doaj.org/article/f720fead0f634b2e88a84576c7772e8d
Autor:
Evelynn Vergauwen, Anne-Marie Vanbinst, Carola Brussaard, Peter Janssens, Dieter De Clerck, Michel Van Lint, Anne C. Houtman, Olaf Michel, Kathelijn Keymolen, Bieke Lefevere, Susanne Bohler, Dirk Michielsen, Anna C. Jansen, Vera Van Velthoven, Sven Gläsker
Publikováno v:
Hereditary Cancer in Clinical Practice, Vol 16, Iss 1, Pp 1-9 (2018)
Abstract Background Patients with hereditary tumor syndromes undergo periodical magnetic resonance imaging (MRI) screening with Gadolinium contrast. Gadolinium accumulation has recently been described in the central nervous system after repeated admi
Externí odkaz:
https://doaj.org/article/2b166d78134048589910c4a810875367
Autor:
Yuan Ji, Marlieke G. Veldhuis, Jantien Zandvoort, Fee L. Romunde, Marien J. C. Houtman, Karen Duran, Gijs van Haaften, Eva-Maria Zangerl-Plessl, Hiroki Takanari, Anna Stary-Weinzinger, Marcel A. G. van der Heyden
Publikováno v:
Journal of Biomedical Science, Vol 24, Iss 1, Pp 1-10 (2017)
Abstract Background The inward rectifier potassium current IK1 contributes to a stable resting membrane potential and phase 3 repolarization of the cardiac action potential. KCNJ2 gain-of-function mutations V93I and D172N associate with increased IK1
Externí odkaz:
https://doaj.org/article/efbd78c2599d487c96e896e9cb6f2763
Autor:
Muge Qile, Yuan Ji, Marien J. C. Houtman, Marlieke Veldhuis, Fee Romunde, Bart Kok, Marcel A. G. van der Heyden
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
KIR2.1 potassium channels, producing inward rectifier potassium current (IK1), are important for final action potential repolarization and a stable resting membrane potential in excitable cells like cardiomyocytes. Abnormal KIR2.1 function, either de
Externí odkaz:
https://doaj.org/article/4879b9edd99e4745970180a8414bb651
Autor:
Xingyu Chen, Arthur Garon, Marcus Wieder, Marien J. C. Houtman, Eva-Maria Zangerl-Plessl, Thierry Langer, Marcel A. G. van der Heyden, Anna Stary-Weinzinger
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
KATP channels consist of four Kir6.x pore–forming subunits and four regulatory sulfonylurea receptor (SUR) subunits. These channels couple the metabolic state of the cell to membrane excitability and play a key role in physiological processes such
Externí odkaz:
https://doaj.org/article/aa05dd91a1274bf398cbe231dc7803e6
Autor:
Isaac J Jensen, Christina S Winborn, Micaela G Fosdick, Peng Shao, Mikaela M Tremblay, Qiang Shan, Sandeep Kumar Tripathy, Christopher M Snyder, Hai-Hui Xue, Thomas S Griffith, Jon C Houtman, Vladimir P Badovinac
Publikováno v:
PLoS Pathogens, Vol 14, Iss 10, p e1007405 (2018)
The sepsis-induced cytokine storm leads to severe lymphopenia and reduced effector capacity of remaining/surviving cells. This results in a prolonged state of immunoparalysis, that contributes to enhanced morbidity/mortality of sepsis survivors upon
Externí odkaz:
https://doaj.org/article/03b923b0ce134deaa8ed4995b5e1b679
Autor:
Jessica L Hastie, Kyle B Williams, Lindsey L Bohr, Jon C Houtman, Lokesh Gakhar, Craig D Ellermeier
Publikováno v:
PLoS Genetics, Vol 12, Iss 9, p e1006287 (2016)
σ factors provide RNA polymerase with promoter specificity in bacteria. Some σ factors require activation in order to interact with RNA polymerase and transcribe target genes. The Extra-Cytoplasmic Function (ECF) σ factor, σV, is encoded by sever
Externí odkaz:
https://doaj.org/article/9b9ce2b969a8457c9e4619de0bbbaf19
Autor:
Muge Qile, Gijs van Haaften, Anna Stary-Weinzinger, Karen Duran, Marcel A.G. van der Heyden, Marien J C Houtman, Xingyu Chen
Publikováno v:
Journal of Cellular and Molecular Medicine
Journal of Cellular and Molecular Medicine, 23(8), 4962. Wiley-Blackwell
Journal of Cellular and Molecular Medicine, 23(8), 4962. Wiley-Blackwell
Cantú syndrome (CS) is caused by dominant gain‐of‐function mutation in ATP‐dependent potassium channels. Cellular ATP concentrations regulate potassium current thereby coupling energy status with membrane excitability. No specific pharmacother
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10653c6322dd2bb1123bd7e73ec43149
http://europepmc.org/articles/PMC7346732
http://europepmc.org/articles/PMC7346732