Zobrazeno 1 - 10
of 1 098
pro vyhledávání: '"A C, Hopkins"'
Autor:
David T. Mitchell, MD, Noa G. Koppin, BS, Michael T. Talanker, BS, Mohin A. Bhadkamkar, MD, Erik S. Marques, MD, Matthew R. Greives, MD, David C. Hopkins, MD
Publikováno v:
Plastic and Reconstructive Surgery, Global Open, Vol 12, Iss 9, p e6191 (2024)
Background:. Unlike in-house call, the Accreditation Council for Graduate Medical Education (ACGME) does not require a postcall day for “home call” shifts. Despite this, we hypothesize that on-call residents are still in the hospital for the majo
Externí odkaz:
https://doaj.org/article/21979865725e4a06b512fff103a62e1b
Autor:
G. K. Scadding, C. Gray, D. M. Conti, M. McDonald, V. Backer, G. Scadding, M. Bernal-Sprekelsen, E. De Corso, Z. Diamant, C. Hopkins, M. Jesenak, P. Johansen, J. Kappen, J. Mullol, D. Price, S. Quirce, S. Reitsma, S. Toppila-Salmi, B. Senior, J. P. Thyssen, U. Wahn, P. W. Hellings
Publikováno v:
Frontiers in Allergy, Vol 5 (2024)
The concept of pre-diabetes has led to provision of measures to reduce disease progression through identification of subjects at risk of diabetes. We previously considered the idea of pre-asthma in relation to allergic asthma and considered that, in
Externí odkaz:
https://doaj.org/article/a74a1472bb1242eba0f900a96a21ef0c
Publikováno v:
BMJ Open, Vol 14, Iss 5 (2024)
Objectives Adverse childhood experiences (ACEs) can affect individuals’ resilience to stressors and their vulnerability to mental, physical and social harms. This study explored associations between ACEs, financial coping during the cost-of-living
Externí odkaz:
https://doaj.org/article/10d164fcbcaf48a59ee75fafcc2235b5
Publikováno v:
Pharmacology Research & Perspectives, Vol 12, Iss 2, Pp n/a-n/a (2024)
Abstract Ulotaront (SEP‐363856) is a TAAR1 agonist, with 5‐HT1A agonist activity, currently in clinical development for the treatment of schizophrenia. In vitro studies indicate ulotaront is an OCT2‐specific inhibitor with IC50 of 1.27 μM. The
Externí odkaz:
https://doaj.org/article/6ab6e839dc2b4529b1b2f4f221971a6c
Autor:
Francesca Perini, Jadwiga Maria Nazimek, Shane Mckie, Liliana P. Capitão, Jessica Scaife, Deepa Pal, Michael Browning, Gerard R. Dawson, Hiroyuki Nishikawa, Una Campbell, Seth C. Hopkins, Antony Loebel, Rebecca Elliott, Catherine J. Harmer, Bill Deakin, Kenneth S. Koblan
Publikováno v:
Schizophrenia, Vol 9, Iss 1, Pp 1-11 (2023)
Abstract Ulotaront, a trace amine-associated receptor 1 (TAAR1) and serotonin 5-HT1A receptor agonist without antagonist activity at dopamine D2 or the serotonin 5-HT2A receptors, has demonstrated efficacy in the treatment of schizophrenia. Here we r
Externí odkaz:
https://doaj.org/article/8e93de31cac74e1c866d57bdd55e4b8e
Autor:
Nina Dedic, Lien Wang, Eva Hajos-Korcsok, Jacob Hecksher-Sørensen, Urmas Roostalu, Steven P. Vickers, Serena Wu, Christoph Anacker, Colleen Synan, Philip G. Jones, Snezana Milanovic, Seth C. Hopkins, Linda J. Bristow, Kenneth S. Koblan
Publikováno v:
Molecular Metabolism, Vol 80, Iss , Pp 101883- (2024)
Objective: Metabolic Syndrome, which can be induced or exacerbated by current antipsychotic drugs (APDs), is highly prevalent in schizophrenia patients. Recent preclinical and clinical evidence suggest that agonists at trace amine-associated receptor
Externí odkaz:
https://doaj.org/article/b7fe5a8971f046fa9b051d0ee080c127
Autor:
G. K. Scadding, M. McDonald, V. Backer, G. Scadding, M. Bernal-Sprekelsen, D. M. Conti, E. De Corso, Z. Diamant, C. Gray, C. Hopkins, M. Jesenak, P. Johansen, J. Kappen, J. Mullol, D. Price, S. Quirce, S. Reitsma, S. Salmi, B. Senior, J. P. Thyssen, U. Wahn, P. W. Hellings
Publikováno v:
Frontiers in Allergy, Vol 4 (2024)
Asthma, which affects some 300 million people worldwide and caused 455,000 deaths in 2019, is a significant burden to suffers and to society. It is the most common chronic disease in children and represents one of the major causes for years lived wit
Externí odkaz:
https://doaj.org/article/782331af574a44d995c7d238b04195cf
Autor:
Hironobu Tsukada, Snezana M. Milanovic, Borje Darpo, Hongqi Xue, Kuangnan Xiong, Emily Tripp, Lisa Lennek, MaryAlice Worden, Seth C. Hopkins, Gerald R. Galluppi
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 6, Pp 1063-1074 (2023)
Abstract This study (NCT04369391) evaluated the effects of ulotaront (SEP‐363856), a novel trace amine‐associated receptor 1 (TAAR1) agonist in development for schizophrenia, on electrocardiogram parameters. Study design was a randomized, single
Externí odkaz:
https://doaj.org/article/fb931202cdb44672bb881bd23a3cb680
Autor:
Josh N. Vo, Yi-Mi Wu, Jeanmarie Mishler, Sarah Hall, Rahul Mannan, Lisha Wang, Yu Ning, Jin Zhou, Alexander C. Hopkins, James C. Estill, Wallace K. B. Chan, Jennifer Yesil, Xuhong Cao, Arvind Rao, Alexander Tsodikov, Moshe Talpaz, Craig E. Cole, Jing C. Ye, Multiple Myeloma Research Consortium, P. Leif Bergsagel, Daniel Auclair, Hearn Jay Cho, Dan R. Robinson, Arul M. Chinnaiyan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The genetic factors involved in disease progression and drug resistance in multiple myeloma (MM) are varied and complex. Here, genomic and transcriptomic profiling of 511 relapsed and refractory MM patients reveals genetic alterations in several onco
Externí odkaz:
https://doaj.org/article/f655f451b78e4e7097fa8cd313e2e43d
Autor:
Christoph U. Correll, Kenneth S. Koblan, Seth C. Hopkins, Yan Li, Heather Dworak, Robert Goldman, Antony Loebel
Publikováno v:
npj Schizophrenia, Vol 7, Iss 1, Pp 1-9 (2021)
Abstract Ulotaront, a trace amine-associated receptor 1 (TAAR1) and serotonin 5-HT1A receptors agonist, has demonstrated efficacy in the treatment of patients with an acute exacerbation of schizophrenia in a 4-week, double-blind, placebo-controlled s
Externí odkaz:
https://doaj.org/article/4df301f738ad41ac8b6310a8ae1d5dbb