Zobrazeno 1 - 10
of 287
pro vyhledávání: '"A C, Dolphin"'
Publikováno v:
Channels, Vol 17, Iss 1 (2023)
ABSTRACTIn this hybrid review, we have first collected and reviewed available information on the structure and function of the enigmatic cache domains in α2δ proteins. These are organized into two double cache (dCache_1) domains, and they are prese
Externí odkaz:
https://doaj.org/article/29b85d8ff155416898076adb66684e7c
Autor:
Aleksandra Topczewska, Elisabetta Giacalone, Wendy S. Pratt, Michele Migliore, Annette C. Dolphin, Mala M. Shah
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112699- (2023)
Summary: Dorsal and ventral medial entorhinal cortex (mEC) regions have distinct neural network firing patterns to differentially support functions such as spatial memory. Accordingly, mEC layer II dorsal stellate neurons are less excitable than vent
Externí odkaz:
https://doaj.org/article/56be061d211b45108b9f50f0c695a6ac
Autor:
James O. Meyer, Annette C. Dolphin
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract N-type voltage-gated calcium channels (CaV2.2) are predominantly expressed at presynaptic terminals, and their function is regulated by auxiliary α2δ and β subunits. All four mammalian α2δ subunits enhance calcium currents through CaV1
Externí odkaz:
https://doaj.org/article/505d687843834437b5e5ce83ac45051f
Publikováno v:
Pain. 164:1264-1279
Neuronal N-type (CaV2.2) voltage-gated calcium channels are essential for neurotransmission from primary afferent terminals in the dorsal horn. In this study we have utilized a knock-in mouse expressing CaV2.2 with an inserted extracellular hemagglut
Publikováno v:
The Journal of Physiology. 600:5333-5351
Autor:
Laurent Ferron, Cesare G. Novazzi, Kjara S. Pilch, Cristian Moreno, Krishma Ramgoolam, Annette C. Dolphin
Publikováno v:
Neurobiology of Disease, Vol 138, Iss , Pp 104779- (2020)
Fragile X syndrome (FXS), the most common form of inherited intellectual disability and autism, results from the loss of fragile X mental retardation protein (FMRP). We have recently identified a direct interaction of FMRP with voltage-gated Ca2+ cha
Externí odkaz:
https://doaj.org/article/780cdc6e52d64a73a01459777141168e
Autor:
James O. Meyer, Shehrazade Dahimene, Karen M. Page, Laurent Ferron, Ivan Kadurin, Joseph I.J. Ellaway, Pengxiang Zhao, Tarun Patel, Simon W. Rothwell, Peipeng Lin, Wendy S. Pratt, Annette C. Dolphin
Publikováno v:
Cell Reports, Vol 29, Iss 1, Pp 22-33.e5 (2019)
Summary: Voltage-gated calcium channels are exquisitely Ca2+ selective, conferred primarily by four conserved pore-loop glutamate residues contributing to the selectivity filter. There has been little previous work directly measuring whether the traf
Externí odkaz:
https://doaj.org/article/b96fac46c3774fd5a3d05be757aa82e6
Autor:
Shehrazade Dahimene, Leonie von Elsner, Tess Holling, Lauren S Mattas, Jess Pickard, Davor Lessel, Kjara S Pilch, Ivan Kadurin, Wendy S Pratt, Igor B Zhulin, Hongzheng Dai, Maja Hempel, Maura R Z Ruzhnikov, Kerstin Kutsche, Annette C Dolphin
Publikováno v:
Brain. 145:2721-2729
Voltage-gated calcium (CaV) channels form three subfamilies (CaV1–3). The CaV1 and CaV2 channels are heteromeric, consisting of an α1 pore-forming subunit, associated with auxiliary CaVβ and α2δ subunits. The α2δ subunits are encoded in mamma
Autor:
Shehrazade Dahimene, Karen M. Page, Manuela Nieto-Rostro, Wendy S. Pratt, Marianna D'Arco, Annette C. Dolphin
Publikováno v:
Neurobiology of Disease, Vol 93, Iss , Pp 243-256 (2016)
Episodic ataxia 2 (EA2) is an autosomal dominant disorder caused by mutations in the gene CACNA1A that encodes the pore-forming CaV2.1 calcium channel subunit. The majority of EA2 mutations reported so far are nonsense or deletion/insertion mutations
Externí odkaz:
https://doaj.org/article/7f9c96e2028b44edbadf8d67e0de0f2f
Autor:
Shehrazade Dahimene, Karen M. Page, Ivan Kadurin, Laurent Ferron, Dominique Y. Ho, Gareth T. Powell, Wendy S. Pratt, Stephen W. Wilson, Annette C. Dolphin
Publikováno v:
Cell Reports, Vol 25, Iss 6, Pp 1610-1621.e5 (2018)
Summary: Voltage-gated calcium channel auxiliary α2δ subunits are important for channel trafficking and function. Here, we compare the effects of α2δ-1 and an α2δ-like protein called Cachd1 on neuronal N-type (CaV2.2) channels, which are import
Externí odkaz:
https://doaj.org/article/18afc7732ea249b79a59826d0608911d