The AF4·MLL fusion protein is capable of inducing ALL in mice without requirement of MLL·AF4

Autor: Bursen, Adelheid ^*, Schwabe, Karen ^*, Rüster, Brigitte, Henschler, Reinhard, Ruthardt, Martin, Dingermann, Theo, Marschalek, Rolf ^*

Publikováno v: In Blood 29 April 2010 115(17):3570-3579

Interaction of AF4 wild-type and AF4·MLL fusion protein with SIAH proteins: indication for t(4;11) pathobiology?

Autor: Bursen, Adeiheid¹, Moritz, Sven¹, Gaussmann, Anne¹, Moritz, Sören², Dingermann, Theo¹, Marschalek, Rolf¹ Rolf.Marschalek@em.uni-frankfurt.de

Publikováno v: Oncogene. 8/19/2004, Vol. 23 Issue 37, p6237-6249. 13p.

Activated KRAS Cooperates with MLL-AF4 to Promote Extramedullary Engraftment and Migration of Cord Blood CD34+ HSPC But Is Insufficient to Initiate Leukemia

Autor: Paola Ballerini, Julio Castaño, Rolf Marschalek, Cristina Prieto, Aldeheid Bursen, Mireia Camós, Ignacio Varela, Pablo Menendez, Antonio Agraz-Doblas, Ronald W. Stam, Clara Bueno

Publikováno v: Cancer Research, 76(8), 2478-2489. American Association for Cancer Research Inc.
Cancer Research
CANCER RESEARCH
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
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r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu

Prieto et al.
The MLL-AF4 (MA4) fusion gene is the genetic hallmark of an aggressive infant pro-B-acute lymphoblastic leukemia (B-ALL). Our understanding of MA4-mediated transformation is very limited. Whole-genome sequencing studies revealed a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5203174be8ca11b7447d8a9bbd4e426
https://pubmed.ncbi.nlm.nih.gov/26837759

Secondary mutations in t(4;11) leukemia patients

Autor: A Bursen, Rolf Marschalek, Theodor Dingermann, C Prelle

Publikováno v: Leukemia

MLL rearrangements are a genetic hallmark of acute leukemia patients, which exhibit a particular poor outcome. To date, more than 70 MLL rearrangements have been described at the molecular level.1 For the most frequently diagnosed MLL rearrangements,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38eedfa97c311494435eb40d528db321
https://doi.org/10.1038/leu.2012.365

Ligand-independent FLT3 activation does not cooperate with MLL-AF4 to immortalize/transform cord blood CD34+ cells

Autor: C Prelle, Aldeheid Bursen, Damia Romero-Moya, Cristina Prieto, Clara Bueno, C Chillón, Pedro J. Real, Oscar Navarro-Montero, Verónica Ayllón, Rosa Montes, Rolf Marschalek, Pablo Menendez

Publikováno v: Leukemia. 28(3)

MLL-AF4 fusion is hallmark in high-risk infant pro-B-acute lymphoblastic leukemia (pro-B-ALL). Our limited understanding of MLL-AF4-mediated transformation reflects the absence of human models reproducing this leukemia. Hematopoietic stem/progenitor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cebab6ed4c721ed7512da50632a0e8a6
https://pubmed.ncbi.nlm.nih.gov/24240202