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Akademický článek

Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus

Autor: Angel Rivera-Calzada, Raquel Arribas-Bosacoma, Alba Ruiz-Ramos, Paloma Escudero-Bravo, Jasminka Boskovic, Rafael Fernandez-Leiro, Antony W. Oliver, Laurence H. Pearl, Oscar Llorca

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)

Vaccinia virus expresses two proteins that interfere with the host immune response. Here, authors provide the structural basis for this viral defence mechanism, conserved in other poxviruses such as the causatives agents of smallpox and monkeypox.

Externí odkaz: https://doaj.org/article/8166a1fa6c9d47a0afe20872a86f6ed5

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Akademický článek

APLF and long non-coding RNA NIHCOLE promote stable DNA synapsis in non-homologous end joining

Autor: Sara De Bragança, Clara Aicart-Ramos, Raquel Arribas-Bosacoma, Angel Rivera-Calzada, Juan Pablo Unfried, Laura Prats-Mari, Mikel Marin-Baquero, Puri Fortes, Oscar Llorca, Fernando Moreno-Herrero

Publikováno v: Cell Reports, Vol 42, Iss 1, Pp 111917- (2023)

Summary: The synapsis of DNA ends is a critical step for the repair of double-strand breaks by non-homologous end joining (NHEJ). This is performed by a multicomponent protein complex assembled around Ku70-Ku80 heterodimers and regulated by accessory

Externí odkaz: https://doaj.org/article/bdd06c938e2c4905878ed00d980ca5c2

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Akademický článek

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Akademický článek

Differences and Similarities between the Lung Transcriptomic Profiles of COVID-19, COPD, and IPF Patients: A Meta-Analysis Study of Pathophysiological Signaling Pathways

Autor: Daniel Aguilar, Adelaida Bosacoma, Isabel Blanco, Olga Tura-Ceide, Anna Serrano-Mollar, Joan Albert Barberà, Victor Ivo Peinado

Publikováno v: Life, Vol 12, Iss 6, p 887 (2022)

Coronavirus disease 2019 (COVID-19) is a pandemic respiratory disease associated with high morbidity and mortality. Although many patients recover, long-term sequelae after infection have become increasingly recognized and concerning. Among other seq

Externí odkaz: https://doaj.org/article/1b6a03a8fdf84b1e8e7bcfa8dde1c19e

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Akademický článek

Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein

Autor: Xiangrong Chen, Yusuf I Ali, Charlotte EL Fisher, Raquel Arribas-Bosacoma, Mohan B Rajasekaran, Gareth Williams, Sarah Walker, Jessica R Booth, Jessica JR Hudson, S Mark Roe, Laurence H Pearl, Simon E Ward, Frances MG Pearl, Antony W Oliver

Publikováno v: eLife, Vol 10 (2021)

BLM (Bloom syndrome protein) is a RECQ-family helicase involved in the dissolution of complex DNA structures and repair intermediates. Synthetic lethality analysis implicates BLM as a promising target in a range of cancers with defects in the DNA dam

Externí odkaz: https://doaj.org/article/9ec1a9ebd4b44f678f41f09602610beb

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Akademický článek

Differences and Similarities between the Lung Transcriptomic Profiles of COVID-19, COPD, and IPF Patients: A Meta-Analysis Study of Pathophysiological Signaling Pathways.

Autor: Aguilar, Daniel^1,2 (AUTHOR) adelaidabosacoma@gmail.com, Bosacoma, Adelaida^2,3 (AUTHOR) iblanco2@clinic.cat, Blanco, Isabel^2,3,4 (AUTHOR) olgaturac@gmail.com, Tura-Ceide, Olga^2,3,4,5 (AUTHOR) anna.serranomollar@iibb.csic.es, Serrano-Mollar, Anna^2,3,6 (AUTHOR) jbarbera@clinic.cat, Barberà, Joan Albert^2,3,4 (AUTHOR), Peinado, Victor Ivo^2,3,4,6 (AUTHOR) vpeinado@iibb.csic.es

Publikováno v: Life (2075-1729). Jun2022, Vol. 12 Issue 6, p887. 16p.

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