Zobrazeno 1 - 10
of 11
pro vyhledávání: '"A B Sanchez-Spitman"'
Autor:
A. B. Sanchez-Spitman, J. J. Swen, V. O. Dezentjé, D. J. A. R. Moes, H. Gelderblom, H. J. Guchelaar
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract CYP2C19*2 and CYP2C19*17 might influence tamoxifen metabolism and clinical outcome. Our aim was to investigate the effect of CYP2C19 genotypes on tamoxifen concentrations and metabolic ratios (MRs) and breast cancer recurrence in a large coh
Externí odkaz:
https://doaj.org/article/59296d30f6094050a721f97177efd78a
Autor:
Hans Gelderblom, Vincent O. Dezentjé, Jesse J. Swen, Henk-Jan Guchelaar, A B Sanchez-Spitman, D J A R Moes
Publikováno v:
Expert Review of Clinical Pharmacology, 12(6), 523-536
Introduction: Tamoxifen dominates the anti-estrogenic therapy in the early and metastatic breast cancer setting. Tamoxifen has a complex metabolism, being mainly metabolized by CYP2D6 into its 30-100 times more potent metabolite, endoxifen. Recently,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::733cb35d6e656a1278c55ec8fb619b6c
https://doi.org/10.1080/17512433.2019.1610390
https://doi.org/10.1080/17512433.2019.1610390
Autor:
Hans Gelderblom, H-J Guchelaar, J.J. Swen, A B Sanchez-Spitman, D J A R Moes, Vincent O. Dezentjé
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports, 11(1). NATURE RESEARCH
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports, 11(1). NATURE RESEARCH
CYP2C19*2 and CYP2C19*17 might influence tamoxifen metabolism and clinical outcome. Our aim was to investigate the effect of CYP2C19 genotypes on tamoxifen concentrations and metabolic ratios (MRs) and breast cancer recurrence in a large cohort of Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::931ba3f35ef67b3d4bbdf30d0581f35d
https://hdl.handle.net/1887/3196264
https://hdl.handle.net/1887/3196264
Autor:
Henk-Jan Guchelaar, Hans Gelderblom, Diether Lambrechts, Vincent O. Dezentjé, D J A R Moes, A B Sanchez-Spitman, Jesse J. Swen, Patrick Neven
Publikováno v:
Cancer Chemotherapy and Pharmacology
Cancer Chemotherapy and Pharmacology, 85(6), 1141-1152. SPRINGER
Cancer Chemotherapy and Pharmacology, 85(6), 1141-1152. SPRINGER
Purpose Tamoxifen is part of endocrine therapy in breast cancer treatment. Studies have indicated the use of endoxifen concentrations, tamoxifen active metabolite, to guide tamoxifen efficacy. Three endoxifen thresholds have been suggested (5.9 ng/ml
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e68c10a718a775049582204dde4f0d56
https://hdl.handle.net/1887/3181912
https://hdl.handle.net/1887/3181912
Autor:
Henk-Jan Guchelaar, Vincent O. Dezentjé, Jesse J. Swen, D J A R Moes, Hans Gelderblom, A B Sanchez-Spitman
Publikováno v:
Breast Cancer Research and Treatment, 172(2), 401-411
Breast Cancer Research and Treatment
Breast Cancer Research and Treatment
Purpose Tamoxifen has a wide inter-variability. Recently, two SNPs in the 3′-untranslated region (UTR) of the SULT1A1 gene, rs6839 and rs1042157, have been associated with decreased SULT1A1 activity. The aim of this study is to investigate the role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab0624cfcb8db54ea964e357d9e7819f
https://doi.org/10.1007/s10549-018-4923-7
https://doi.org/10.1007/s10549-018-4923-7
Autor:
Hans Gelderblom, A B Sanchez-Spitman, Henk-Jan Guchelaar, Vincent O. Dezentjé, Jesse J. Swen, Stefan Böhringer, Patrick Neven
Publikováno v:
J Clin Oncol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73cc760d41d8a2c9bade544375104bb6
https://pubmed.ncbi.nlm.nih.gov/31211604
https://pubmed.ncbi.nlm.nih.gov/31211604
Autor:
Stefan Böhringer, Dirk Jan A.R. Moes, Henk-Jan Guchelaar, Maartje Los, Carolien H. Smorenburg, Hans Gelderblom, Vincent O. Dezentjé, Patrick Neven, Edith van Druten, Lynn Jongen, Erdogan Batman, Jesse J. Swen, A B Sanchez-Spitman, Aart van Bochove, Anneke Zeillemaker
Publikováno v:
Journal of Clinical Oncology, 37(8), 636
PURPOSE Tamoxifen is widely prescribed as adjuvant therapy in patients with early-stage breast cancer. It has been postulated that concentrations of endoxifen, the active metabolite of tamoxifen, are a better predictor of tamoxifen efficacy than CYP2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78af074106d5afd069289678ab2ec826
https://hdl.handle.net/1887/120026
https://hdl.handle.net/1887/120026
Autor:
Henk-Jan Guchelaar, A. B. Sanchez Spitman, Vincent O. Dezentjé, D J A R Moes, Jesse J. Swen, Hans Gelderblom
Publikováno v:
European Journal of Clinical Pharmacology, 73(12), 1589-1598
European Journal of Clinical Pharmacology
European Journal of Clinical Pharmacology
Background Tamoxifen is one of the cornerstones of endocrine therapy for breast cancer. Recently, the decreased activity CYP3A4*22 allele and the loss of function CYP3A5*3 allele have been described as potential factors that could help to explain the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e888628634e5a5e586f1122247f609e9
https://hdl.handle.net/1887/116042
https://hdl.handle.net/1887/116042
Autor:
Henk-Jan Guchelaar, A B Sanchez-Spitman, Vincent O. Dezentjé, D J A R Moes, Jesse J. Swen, Hans Gelderblom
Publikováno v:
Pharmacogenomics, 18(12), 1125-1132
Aim: CYP2D6*2 is considered fully active, but it has been suggested that it only happens in the presence of rs5758550. This study aims to elucidate the impact of this enhancer. Materials & methods: DNA and blood samples from women enrolled in the CYP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66ad4c0264b3d1ed7e0c7c049733711a
https://doi.org/10.2217/pgs-2017-0080
https://doi.org/10.2217/pgs-2017-0080
Autor:
Vincent O. Dezentjé, Stefanie L. Groenland, N. P. van Erp, A B Sanchez-Spitman, D J A R Moes, A. D. R. Huitema, Neeltje Steeghs, H-J Guchelaar, Ron H.J. Mathijssen, Stijn L.W. Koolen
Publikováno v:
Annals of Oncology. 29:viii82
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba3283993fa97d1d0a24b8eacbeddfb3
https://doi.org/10.1093/annonc/mdy270.252
https://doi.org/10.1093/annonc/mdy270.252