Výsledky vyhledávání

Phase 1 and Phase 2 Studies ofSalmonella entericaSerovar Paratyphi A O-Specific Polysaccharide-Tetanus Toxoid Conjugates in Adults, Teenagers, and 2- to 4-Year-Old Children in Vietnam

Autor: Tran Cong Thanh, Arthur B. Karpas, Dang Duc Trach, Jianping Li, Edward Konadu, Nguyen Thi Thanh Thuy, Vo Anh Ho, Shousun C. Szu, Feng-Ying C. Lin, Dolores A. Bryla, John B. Robbins, Ha Ba Khiem, Phan Van Be Bay

Publikováno v: Infection and Immunity. 68:1529-1534

Salmonella entericaserovar Paratyphi A O-specific polysaccharide (O-SP) was activated with 1-cyano-4-dimethylaminopyridinium tetrafluoroborate (CDAP) and bound to tetanus toxoid (TT) with adipic acid dihydrazide as a linker (SPA-TT1) or directly (SPA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1da702635e84c34eec6089d31906602
https://doi.org/10.1128/iai.68.3.1529-1534.2000

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Differential Expression of Vibrio vulnificus Capsular Polysaccharide

Autor: Arthur B. Karpas, JL Powell, LA Ensor, Michael K. Tanner, A C Wright, Jr Jg Morris, Marcelo B. Sztein

Publikováno v: Infection and Immunity. 67:2250-2257

Vibrio vulnificus is a human pathogen whose virulence has been associated with the expression of capsular polysaccharide (CPS). Multiple CPS types have been described; however, virulence does not appear to correlate with a particular CPS composition.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad51d5a0027512a8e9138aa164f1219d
https://doi.org/10.1128/iai.67.5.2250-2257.1999

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Identification of Common Lipooligosaccharide Types in Isolates from Patients with Otitis Media by Monoclonal Antibodies against Nontypeable Haemophilus influenzae 9274

Autor: Tomoyo Ueyama, David J. Lim, Arthur B. Karpas, Xin Xing Gu, Chao Ming Tsai

Publikováno v: Clinical Diagnostic Laboratory Immunology. 6:96-100

Twenty-one murine monoclonal antibodies (MAbs) were induced by nontypeable Haemophilus influenzae (NTHi) 9274. Nineteen MAbs were specific for the lipooligosaccharide (LOS) as determined by enzyme-linked immunosorbent assay (ELISA) and Western blot a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3128befb2c3371850bc19a60c70dd05
https://doi.org/10.1128/cdli.6.1.96-100.1999

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A murine antibody to Shigella dysenteriae type 1 employs V-genes that contain a rearranged codon for the λ light chain

Autor: D. Siwarski, Cornelis P.J. Glaudemans, Charles E. Miller, Konrad Huppi, Arthur B. Karpas, C R Mainhart, Andrew Newman

Publikováno v: Molecular Immunology. 32:679-682

The cDNA coding for a hybridoma anti Shigella dysenteriae type 1 antibody (3707 E9) has been cloned, and sequenced. Binding patterns with fragments of the bacterial polysaccharide antigen had already been studied in detail. The VH sequence utilizes t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cbcbe6829833e9b06f0b89eae5696a1
https://doi.org/10.1016/0161-5890(95)00072-m

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Phase 1 Study of a Recombinant Mutant Protective Antigen of Bacillus anthracis

Autor: Rachel Schneerson, Feng-Ying C. Lin, German A. Benavides, Joseph Shiloach, Chunyan Guo, Mahtab Moayeri, Joseph A. Bellanti, Stephen H. Leppla, Chiayung Chu, John B. Robbins, Arthur B. Karpas

A phase 1 study of a recombinant mutant protective antigen (rPA) vaccine was conducted in 186 healthy adults aged 18 to 45 years. Volunteers were randomized to receive one of three formulations of rPA (formalin treated, alum adsorbed, or both), in 10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0942d9f88143a18cd1d6ab6281e3d6a
https://europepmc.org/articles/PMC3272932/

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Immunological characterization of recombinant antigens isolated from a Mycobacterium avium lambda gt11 expression library by using monoclonal antibody probes

Autor: A B Karpas, S D Chaparas, D A Rouse, P G Probst, Sheldon L. Morris, J.C. Mackall

Publikováno v: Infection and Immunity. 59:2595-2600

Nontuberculous mycobacteria, particularly Mycobacterium avium, have been isolated from a significant percentage of patients with AIDS. Early detection of M. avium infection is difficult, and treatment regimens are often ineffective. Much needs to be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::126ebe3e6abefa3b6ad429c06da82f60
https://doi.org/10.1128/iai.59.8.2595-2600.1991

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Production, characterization, and species specificity of monoclonal antibodies to Mycobacterium avium complex protein antigens

Autor: S D Chaparas, P G Probst, D A Rouse, A B Karpas, Sheldon L. Morris

Publikováno v: Infection and Immunity. 58:1445-1449

The incidence of Mycobacterium avium-Mycobacterium intracellulare complex infections has increased in recent years primarily because a significant proportion of acquired immunodeficiency syndrome patients develop disseminated M. avium complex disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96de50d3c9d408576a04035498a42d6a
https://doi.org/10.1128/iai.58.5.1445-1449.1990

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Safety and immunogenicity of Vi conjugate vaccines for typhoid fever in adults, teenagers, and 2- to 4-year-old children in Vietnam

Autor: Rachel Schneerson, Nguyen Thi Thanh Thuy, Shousun C. Szu, Zuzana Kossaczka, Dolores A. Bryla, Tran Cong Thanh, Feng-Ying C. Lin, Arthur B. Karpas, Steven Hunt, Vo Anh Ho, Dang Duc Trach, Ha Ba Khiem, Phan Van Be Bay, John B. Robbins

Publikováno v: Infection and immunity. 67(11)

The capsular polysaccharide of Salmonella typhi, Vi, is an essential virulence factor and a protective vaccine for people older than 5 years. The safety and immunogenicity of two investigational Vi conjugate vaccines were evaluated in adults, 5- to 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::425e767fd7c97f60096ae82ac5d6bb44
https://pubmed.ncbi.nlm.nih.gov/10531232

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Safety and immunogenicity of Shigella sonnei and Shigella flexneri 2a O-specific polysaccharide conjugates in children

Autor: Ron Dagan, Justen H. Passwell, Fathy Majadly, Nahid Farzan, Dan Miron, Reut Ramon, Dolores A. Bryla, Efrat Harlev, Arthur B. Karpas, Shai Ashkenazi, John B. Robbins, Rachel Schneerson

Publikováno v: The Journal of infectious diseases. 179(6)

O-specific polysaccharide conjugates of shigellae were safe and immunogenic in young adults, and a Shigella sonnei conjugate conferred protection [1-3]. Shigellosis is primarily a disease of children; therefore, the safety and immunogenicity of S. so

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef9305e810463f2b96c5fb0531cbefe3
https://pubmed.ncbi.nlm.nih.gov/10228084

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Differential posttranslational processing confers intraspecies variation of a major surface lipoprotein and a macrophage-activating lipopeptide of Mycoplasma fermentans

Autor: Michael J. Calcutt, Peter F. Mühlradt, Arthur B. Karpas, Kim S. Wise, M F Kim

Publikováno v: Infection and immunity. 67(2)

The malp gene of Mycoplasma fermentans is shown to occur in single copy but to encode two discrete translated forms of lipid-modified surface protein that can be differentially expressed on isolates within this species: MALP-2, a 14-amino-acid (2-kDa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ac19e1aa6f03f45bc42c804ab6334cf
https://pubmed.ncbi.nlm.nih.gov/9916088

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