Zobrazeno 1 - 10
of 3 491
pro vyhledávání: '"A B, Ward"'
Autor:
Melanie R. Walker, Alexander Underwood, Kasper H. Björnsson, Sai Sundar Rajan Raghavan, Maria R. Bassi, Alekxander Binderup, Long V. Pham, Santseharay Ramirez, Mette Pinholt, Robert Dagil, Anne S. Knudsen, Manja Idorn, Max Soegaard, Kaituo Wang, Andrew B. Ward, Ali Salanti, Jens Bukh, Lea Barfod
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract The continuous emergence of SARS-CoV-2 variants of concern has rendered many therapeutic monoclonal antibodies (mAbs) ineffective. To date, there are no clinically authorized therapeutic antibodies effective against the recently circulating
Externí odkaz:
https://doaj.org/article/2b11d3e3d9f0431f9a67e240f7b90062
Autor:
Marloes Grobben, Margreet Bakker, Angela I Schriek, Liesbeth J J Levels, Jeffrey C Umotoy, Khadija Tejjani, Mariëlle J van Breemen, Ryan N Lin, Steven W de Taeye, Gabriel Ozorowski, Neeltje A Kootstra, Andrew B Ward, Stephen J Kent, P Mark Hogarth, Bruce D Wines, Rogier W Sanders, Amy W Chung, Marit J van Gils
Publikováno v:
PLoS Pathogens, Vol 20, Iss 12, p e1012739 (2024)
HIV-1 infection leads to chronic disease requiring life-long treatment and therefore alternative therapeutics, a cure and/or a protective vaccine are needed. Antibody-mediated effector functions could have a role in the fight against HIV-1. However,
Externí odkaz:
https://doaj.org/article/b7fc8d66d7814d5bb991e391aaec82f3
Autor:
Denise Guerra, Laura Radić, Mitch Brinkkemper, Meliawati Poniman, Lara van der Maas, Jonathan L. Torres, Andrew B. Ward, Kwinten Sliepen, Janke Schinkel, Rogier W. Sanders, Marit J. van Gils, Tim Beaumont
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 20, Iss 1 (2024)
Monoclonal neutralizing antibodies (mAbs) are considered an important prophylactic against SARS-CoV-2 infection in at-risk populations and a strategy to counteract future sarbecovirus-induced disease. However, most mAbs isolated so far neutralize onl
Externí odkaz:
https://doaj.org/article/1fbcc6e3d1d94ac096e091f76a23bb0a
Publikováno v:
Biogeosciences, Vol 21, Pp 3215-3238 (2024)
Nitrous oxide (N2O) is a potent greenhouse gas and ozone depletion agent, with a significant natural source from marine oxygen-deficient zones (ODZs). Open questions remain, however, about the microbial processes responsible for this N2O production,
Externí odkaz:
https://doaj.org/article/7a52158e3f6e43a1b068d3f6886163d1
Publikováno v:
Biogeosciences, Vol 21, Pp 3239-3250 (2024)
Nitrous oxide (N2O), a potent greenhouse gas and ozone-destroying agent, is produced during nitrogen transformations in both natural and human-constructed environments. Wastewater treatment plants (WWTPs) produce and emit N2O into the atmosphere duri
Externí odkaz:
https://doaj.org/article/8fdc806214bc4563981b2916acfdb126
Autor:
Christopher A. Cottrell, Payal P. Pratap, Kimberly M. Cirelli, Diane G. Carnathan, Chiamaka A. Enemuo, Aleksandar Antanasijevic, Gabriel Ozorowski, Leigh M. Sewall, Hongmei Gao, Joel D. Allen, Bartek Nogal, Murillo Silva, Jinal Bhiman, Matthias Pauthner, Darrell J. Irvine, David Montefiori, Max Crispin, Dennis R. Burton, Guido Silvestri, Shane Crotty, Andrew B. Ward
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-14 (2024)
Abstract Immunodominance of antibodies targeting non-neutralizing epitopes and the high level of somatic hypermutation within germinal centers (GCs) required for most HIV broadly neutralizing antibodies (bnAbs) are major impediments to the developmen
Externí odkaz:
https://doaj.org/article/bdb802dbabe14d2b9e05554af9fa7556
Autor:
Philip J.M. Brouwer, Hailee R. Perrett, Tim Beaumont, Haye Nijhuis, Sabine Kruijer, Judith A. Burger, Ilja Bontjer, Wen-Hsin Lee, James A. Ferguson, Martin Schauflinger, Helena Müller-Kräuter, Rogier W. Sanders, Thomas Strecker, Marit J. van Gils, Andrew B. Ward
Publikováno v:
Cell Reports, Vol 43, Iss 9, Pp 114708- (2024)
Summary: Lassa fever continues to be a major public health burden in West Africa, yet effective therapies or vaccines are lacking. The isolation of protective neutralizing antibodies against the Lassa virus glycoprotein complex (GPC) justifies the de
Externí odkaz:
https://doaj.org/article/6024a95cb789487bbd0a23b8611ae42e
Autor:
Iván del Moral-Sánchez, Edmund G. Wee, Yuejiao Xian, Wen-Hsin Lee, Joel D. Allen, Alba Torrents de la Peña, Rebeca Fróes Rocha, James Ferguson, André N. León, Sylvie Koekkoek, Edith E. Schermer, Judith A. Burger, Sanjeev Kumar, Robby Zwolsman, Mitch Brinkkemper, Aafke Aartse, Dirk Eggink, Julianna Han, Meng Yuan, Max Crispin, Gabriel Ozorowski, Andrew B. Ward, Ian A. Wilson, Tomáš Hanke, Kwinten Sliepen, Rogier W. Sanders
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-18 (2024)
Abstract Recombinant native-like HIV-1 envelope glycoprotein (Env) trimers are used in candidate vaccines aimed at inducing broadly neutralizing antibodies. While state-of-the-art SOSIP or single-chain Env designs can be expressed as native-like trim
Externí odkaz:
https://doaj.org/article/9406da7e97304295838f177acd6e13b0
Autor:
Javier Guenaga, Mehrdad Alirezaei, Yu Feng, Mohamad-Gabriel Alameh, Wen-Hsin Lee, Sabyasachi Baboo, Jocelyn Cluff, Richard Wilson, Shridhar Bale, Gabriel Ozorowski, Paulo Lin, Ying Tam, Jolene K. Diedrich, John R. Yates, James C. Paulson, Andrew B. Ward, Drew Weissman, Richard T. Wyatt
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The HIV-1 envelope glycoprotein (Env) is the sole neutralizing determinant on the surface of the virus. The Env gp120 and gp41 subunits mediate receptor binding and membrane fusion and are generated from the gp160 precursor by cellular furins. This c
Externí odkaz:
https://doaj.org/article/37d2ab50b881474f81175ff5bf88cc4e
Autor:
Jonathan Hurtado, Thomas F. Rogers, David B. Jaffe, Bruce A. Adams, Sandhya Bangaru, Elijah Garcia, Tazio Capozzola, Terrence Messmer, Pragati Sharma, Ge Song, Nathan Beutler, Wanting He, Katharina Dueker, Rami Musharrafieh, Sarah Burbach, Alina Truong, Michael J.T. Stubbington, Dennis R. Burton, Raiees Andrabi, Andrew B. Ward, Wyatt J. McDonnell, Bryan Briney
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114307- (2024)
Summary: The development of vaccines and therapeutics that are broadly effective against known and emergent coronaviruses is an urgent priority. We screened the circulating B cell repertoires of COVID-19 survivors and vaccinees to isolate over 9,000
Externí odkaz:
https://doaj.org/article/f79894ea6aa64842a740394d85fccf3e