Výsledky vyhledávání - "A B, Straughn"

Autor: Ian B. Straughn

Publikováno v: Imagining Antiquity in Islamic Societies ISBN: 9781789385496

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a7cb03ae0737e48831bfcf55b695393e
https://doi.org/10.2307/j.ctv36xvm35.15

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Modulation of Response Regulator CheY Reaction Kinetics by Two Variable Residues That Affect Conformation

Autor: Philip B. Straughn, Robert B. Bourret, Luke R. Vass, Emily N. Kennedy, Chase Yuan, Clay A. Foster

Publikováno v: J Bacteriol

Microorganisms and plants utilize two-component systems to regulate adaptive responses to changing environmental conditions. Sensor kinases detect stimuli and alter their autophosphorylation activity accordingly. Signal propagation occurs via the tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ab18d11f8e4fb3a1e776e7e01edb57b
https://doi.org/10.1128/jb.00089-20

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Drug Regimen Individualization for Attention-Deficit/Hyperactivity Disorder: Guidance for Methylphenidate and Dexmethylphenidate Formulations

Autor: Arthur B. Straughn, Wendy Rodriguez, Jennifer L. Radke, Kennerly S. Patrick, John R. Raymond, Linda V. Nguyen, Lauren Koller

Publikováno v: Pharmacotherapy. 39(6)

In 2000, the first biphasic modified-release (MR) formulation of methylphenidate (MPH) was approved for the treatment of attention-deficit/hyperactivity disorder (ADHD). An immediate-release (IR) MPH pulse (22% of the dose) facilitates rapid onset of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1ed620dd8a4a9414c13c4220afe7ba1
https://pubmed.ncbi.nlm.nih.gov/30351459

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Ethanol Interactions with Dexmethylphenidate and dl-Methylphenidate Spheroidal Oral Drug Absorption Systems in Healthy Volunteers

Autor: Kennerly S. Patrick, John S. Markowitz, Hao Jie Zhu, Owen T. Reeves, Arthur B. Straughn, Joshua M. Knight, Aaron Smith, Heather J. Johnson, Robert Malcolm, Jian Shi, Hilary J. Bernstein

Ethanol coadministered with immediate-release dl-methylphenidate (dl-MPH) or dexmethylphenidate (d-MPH) significantly increases the geomean maximum plasma concentration (Cmax) of d-MPH 22% and 15%, respectively, and elevates overall drug exposure and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5adbb8dedc185bf22c4c9ad75f3b47a6
https://europepmc.org/articles/PMC5484776/

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Differential Influences of Ethanol on Early Exposure to Racemic Methylphenidate Compared with Dexmethylphenidate in Humans

Autor: Kennerly S. Patrick, Owen T. Reeves, Guinevere H Bell, Erica Anderson, Hilary J. Bernstein, Robert Malcolm, Arthur B. Straughn

Publikováno v: Drug Metabolism and Disposition. 41:197-205

Enantioselective hydrolysis of oral racemic methylphenidate (dl-MPH) by carboxylesterase 1 (CES1) limits the absolute bioavailability of the pharmacologically active d-MPH isomer to approximately 30% and that of the inactive l-MPH to only 1-2%. Coadm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::403a39c24587c956337a72a574f266b6
https://doi.org/10.1124/dmd.112.048595

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Absorption Differences between Immediate-Release Dexmethylphenidate and dl-Methylphenidate

Autor: Kennerly S. Patrick, Arthur B. Straughn

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 44(3)

The postulate that twice the milligram/kilogram dose of dl-methylphenidate (dl-MPH) would result in equal exposure to d-MPH compared with half that milligram/kilogram dose of the chiral switch product dexmethylphenidate (d-MPH) was tested. Using a ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d17f7b43da45172083ee1c4827b50a51
https://pubmed.ncbi.nlm.nih.gov/26729760

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Comparative Ethanol-Induced Potentiation of Stimulatory Responses to Dexmethylphenidate Versus Methylphenidate

Autor: Arthur B. Straughn, Kennerly S. Patrick, Owen T. Reeves, Hilary J. Bernstein, Robert Malcolm

Publikováno v: Journal of clinical psychopharmacology. 35(4)

The potentiation of positive subjective responses to immediate-release dexmethylphenidate (d-MPH) or dl-methylphenidate (dl-MPH) by ethanol was investigated over the time course of maximal drug exposure after a single dose. In a 4-way, randomized, cr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dd89c5694c5cece224674dfd9a5bc07
https://pubmed.ncbi.nlm.nih.gov/26075488

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The Effect of Food on the Relative Bioavailability of Rapidly Dissolving Immediate-Release Solid Oral Products Containing Highly Soluble Drugs

Autor: Patrick J. Faustino, Lawrence J. Lesko, Mehul Mehta, Dale P. Conner, Anthony B. Ciavarella, Ebenezer B. Asafu-Adjaye, Lawrence X. Yu, Yongsheng Yang, Arthur B Straughn, Ajaz S. Hussain, Ameeta Parekh

Publikováno v: Molecular Pharmaceutics. 1:357-362

The purpose of this study is to test the hypothesis that rapidly dissolving immediate-release (IR) solid oral products containing a highly soluble and highly permeable drug [biopharmaceutical classification system (BCS) class I] are bioequivalent und

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f62de4f75fedfff8c2b0ff9050de6be6
https://doi.org/10.1021/mp0499407

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