Zobrazeno 1 - 10
of 54
pro vyhledávání: '"A B, Pupyshev"'
Autor:
Alexander B. Pupyshev, Anna A. Akopyan, Michael V. Tenditnik, Marina V. Ovsyukova, Nina I. Dubrovina, Victor M. Belichenko, Tatiana A. Korolenko, Svetlana A. Zozulya, Tatiana P. Klyushnik, Maria A. Tikhonova
Publikováno v:
Pharmaceutics, Vol 16, Iss 6, p 813 (2024)
In the treatment of experimental neurodegeneration with disaccharide trehalose, various regimens are used, predominantly a 2% solution, drunk for several weeks. We studied the effects of different regimens of dietary trehalose treatment in an amyloid
Externí odkaz:
https://doaj.org/article/35c4efef3f3d44fa9ae20d255f1ef955
Autor:
Alexander B. Pupyshev, Tatyana P. Klyushnik, Anna A. Akopyan, Sandeep Kumar Singh, Maria A. Tikhonova
Publikováno v:
Pharmacological Research, Vol 183, Iss , Pp 106373- (2022)
Induction of autophagy is a prospective approach to the treatment of neurodegeneration. In the recent decade, trehalose attracted special attention. It is an autophagy inducer with negligible adverse effects and is approved for use in humans accordin
Externí odkaz:
https://doaj.org/article/2bb6de8fa85a4b50bdf47ee3af68488c
Autor:
T. A. Korolenko, A. B. Shintyapina, A. B. Pupyshev, A. A. Akopyan, G. S. Russkikh, M. A. Dikovskaya, V. A. Vavilin, E. L Zavjalov, M. A. Tikhonova, T. G. Amstislavskaya
Publikováno v:
Вавиловский журнал генетики и селекции, Vol 23, Iss 4, Pp 390-397 (2019)
Autophagy is a dynamic cellular process involved in the turnover of proteins, protein complexes, and organelles through lysosomal degradation. It is particularly important in neurons, which do not have a proliferative option for cellular repair. Auto
Externí odkaz:
https://doaj.org/article/d27d7019c4124e1b83beba1f459c6e79
Autor:
Tatiana A. Korolenko, Nina I. Dubrovina, Marina V. Ovsyukova, Nataliya P. Bgatova, Michael V. Tenditnik, Alexander B. Pupyshev, Anna A. Akopyan, Natalya V. Goncharova, Chih-Li Lin, Evgeny L. Zavjalov, Maria A. Tikhonova, Tamara G. Amstislavskaya
Publikováno v:
Cells, Vol 10, Iss 10, p 2557 (2021)
Autophagy attenuation has been found in neurodegenerative diseases, aging, diabetes mellitus, and atherosclerosis. In experimental models of neurodegenerative diseases, the correction of autophagy in the brain reverses neuronal and behavioral deficit
Externí odkaz:
https://doaj.org/article/cff7cac16e3b438c8afab5d419c4b85b
Publikováno v:
Bulletin of Experimental Biology and Medicine. 171:425-430
We studied the possibilities of inhibition of neurodegeneration in MPTP-induced model of Parkinson's disease (PD) in C57Bl/6J mice and transgenic model of early PD stage (5-monthold B6.Cg-Tg(Prnp-SNCA*A53T)23Mkle/J mice) by autophagy activation throu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a32532c46f7290c9cbc2f4dd78f91830
https://doi.org/10.1007/s10517-021-05242-z
https://doi.org/10.1007/s10517-021-05242-z
Autor:
A. B. Pupyshev, A.A. Akopyan, T. A. Korolenko, M.V. Tenditnik, V.M. Belichenko, V.A. Vavilin, L. A. Fedoseeva, A.B. Shintyapina, G.S. Russkikh, T.G. Amstislavskaya, Chih-Li Lin, Maria A. Tikhonova
Publikováno v:
Medical University. 3:66-78
Pathological aggregation and accumulation of α-synuclein in neurons play a core role in Parkinson’s disease (PD) while its overexpression is a common PD model. Autophagy-lysosomal pathways are general intraneural mechanisms of protein clearance. E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d65757c47768ba5a22d716682f99c7ec
https://doi.org/10.2478/medu-2020-0008
https://doi.org/10.2478/medu-2020-0008
Publikováno v:
Бюллетень сибирской медицины, Vol 10, Iss 3, Pp 139-144 (2011)
For the determining of the role of clinical data and integral laboratory indices in the valuation of endogenic intoxication (EI) in chronic hepatitis B (HHB) 100 patients and 20 healthy adults were examined. The present symptoms of the disease and th
Externí odkaz:
https://doaj.org/article/ce6afa54f830438ba168fe098b8e32cd
Autor:
Alexander B. Pupyshev, Victor M. Belichenko, Michael V. Tenditnik, Alim A. Bashirzade, Nina I. Dubrovina, Marina V. Ovsyukova, Anna A. Akopyan, Larisa A. Fedoseeva, Tatiana A. Korolenko, Tamara G. Amstislavskaya, Maria A. Tikhonova
Publikováno v:
Pharmacology, biochemistry, and behavior. 217
Alzheimer's disease (AD) is associated with amyloid-β (Aβ) accumulation that might be hindered by autophagy. There are two ways to induce autophagy: through mTOR-dependent and mTOR-independent pathways (here, by means of rapamycin and trehalose, re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3a119f5bc32c167084947e682c0325b
https://pubmed.ncbi.nlm.nih.gov/35609863
https://pubmed.ncbi.nlm.nih.gov/35609863
Autor:
Irina Arkad'evna Bondar', Vadim Valerievich Klimentov, G A Paul', A B Pupyshev, S M Ambrosova
Publikováno v:
Сахарный диабет, Vol 5, Iss 1, Pp 46-49 (2002)
Цель: изучение взаимосвязи экскреции ГАГ с качеством гликемического контроля, стадией ДН и активностью вовлеченных в катаболизм протео
Externí odkaz:
https://doaj.org/article/87634d477cd24e29bc6956a6e2f3ff90
Publikováno v:
Bulletin of experimental biology and medicine. 171(4)
We studied the possibilities of inhibition of neurodegeneration in MPTP-induced model of Parkinson's disease (PD) in C57Bl/6J mice and transgenic model of early PD stage (5-monthold B6.Cg-Tg(Prnp-SNCA*A53T)23Mkle/J mice) by autophagy activation throu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6634606d704253d16aebe55ccc68d39f
https://pubmed.ncbi.nlm.nih.gov/34542745
https://pubmed.ncbi.nlm.nih.gov/34542745