Výsledky vyhledávání

A conserved protein interaction network involving the yeast MAP kinases Fus3 and Kss1

Autor: Walid Sabbagh, Anasua B. Kusari, Douglas M. Molina, Lee Bardwell, Chang S. Lau

Publikováno v: The Journal of Cell Biology

The Saccharomyces cerevisiae mitogen-activated protein kinases (MAPKs) Fus3 and Kss1 bind to multiple regulators and substrates. We show that mutations in a conserved docking site in these MAPKs (the CD/7m region) disrupt binding to an important subs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::348e6f614cfa8728ecfc98621284068c
http://europepmc.org/articles/PMC2172336

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[Untitled]

Autor: Anasua B. Kusari, Shrikrishna Dadke, Jyotirmoy Kusari

Publikováno v: Molecular and Cellular Biochemistry. 221:147-154

We have previously reported a direct in vivo interaction between the activated insulin receptor and protein-tyrosine phosphatase-1B (PTP1B), which leads to an increase in PTP1B tyrosine phosphorylation. In order to determine if PTP1B is a substrate f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33c167ad2dc89e0dc5b199abfe2491a6
https://doi.org/10.1023/a:1010909031310

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[Untitled]

Autor: Shrikrishna S. Dadke, Samuel Rulli, Jyotirmoy Kusari, Anasua B. Kusari, John C.H. Byon

Publikováno v: Molecular and Cellular Biochemistry. 218:131-138

Previously, we have reported that insulin induces the expression of the dual-specificity tyrosine phosphatase Mitogen-activated protein (MAP) kinase phosphatase-1 (MKP-1) and that this may represent a negative feedback mechanism to regulate insulin-s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9141726b587bfeebefb87fbdcc8636ab
https://doi.org/10.1023/a:1007204508882

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Elevated Expression and Activity of Protein-Tyrosine Phosphatase 1B in Skeletal Muscle of Insulin-Resistant Type II Diabetic Goto-Kakizaki Rats

Autor: Jyotirmoy Kusari, Anasua B. Kusari, Najma Begum, Hong C. Li, Shrikrishna S. Dadke

Publikováno v: Biochemical and Biophysical Research Communications. 274:583-589

We investigated the cellular mechanism(s) of insulin resistance associated with non-insulin dependent diabetes mellitus (NIDDM) using skeletal muscles isolated from non-obese, insulin resistant type II diabetic Goto-Kakizaki (GK) rats, a well known g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d35dead49ce1cfcae87ac0dd7adfd09
https://doi.org/10.1006/bbrc.2000.3188

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[Untitled]

Autor: Anasua B. Kusari, Jyotirmoy Kusari, John C.H. Byon

Publikováno v: Molecular and Cellular Biochemistry. 211:27-37

Cells expressing mutant insulin receptors (Y/F2), in which tyrosines 1316 and 1322 have been replaced with phenylalanine, exhibit enhanced insulin-induced MAP kinase activity and DNA synthesis in comparison with cells expressing wild type insulin rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ab65880f459c1b03858d9c936f10e090
https://doi.org/10.1023/a:1007102428735

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[Untitled]

Autor: Jyotirmoy Kusari, John C. H. Byon, Anasua B. Kusari

Publikováno v: Molecular and Cellular Biochemistry. 182:101-108

Insulin signaling involves a dynamic cascade of protein tyrosine phosphorylation and dephosphorylation. Most of our understanding of this process comes from studies focusing on tyrosine kinases, which are signal activators. Our knowledge of the role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d152d9f7d0c2612b5057837b9bf1801d
https://doi.org/10.1023/a:1006868409841

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Regulation of Growth Factor-Induced Signaling by Protein-Tyrosine-Phosphatases

Autor: Jyotirmoy Kusari, Anasua B. Kusari, Kathleen A. Kenner, John C. H. Byon

Publikováno v: Experimental Biology and Medicine. 216:1-20

The binding of a growth factor to its specific receptor catalyzes a complex cascade of intracellular signaling events, characterized by changes in the phosphorylation state of many key proteins. Among these phosphorylation events, tyrosine phosphoryl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eb26a1f8543653007d723f966c6bf16
https://doi.org/10.3181/00379727-216-44153

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Protein-Tyrosine Phosphatase 1B Complexes with the Insulin Receptor in Vivo and Is Tyrosine-phosphorylated in the Presence of Insulin

Autor: Thomas A. Gustafson, Jyotirmoy Kusari, Feng Liu, Anasua B. Kusari, Debdutta Bandyopadhyay, Jonathan Chernoff, Kathleen A. Kenner

Publikováno v: Journal of Biological Chemistry. 272:1639-1645

In response to insulin, protein-tyrosine phosphatase 1B (PTPase 1B) dephosphorylates 95- and 160-180-kDa tyrosine phosphorylated (PY) proteins (Kenner, K. A., Anyanwu, E., Olefsky, J. M., and Kusari, J. (1996) J. Biol. Chem. 271, 19810-19816). To cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb0b042c626aeaea25ad219c79f5c1bf
https://doi.org/10.1074/jbc.272.3.1639

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IL-1 beta and IL-6 selectively induce transforming growth factor-beta isoforms in human articular chondrocytes

Autor: P M Villiger, A B Kusari, P ten Dijke, M Lotz

Publikováno v: The Journal of Immunology. 151:3337-3344

Transforming growth factor-beta (TGF-beta) plays an important role in homeostasis of connective tissues, but regulation of its expression in mesenchymal cells is not well characterized. This study examines the effects of the cytokines IL-1 beta and I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f65b88e92b008383b4a05029eb1b31e9
https://doi.org/10.4049/jimmunol.151.6.3337

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