Zobrazeno 1 - 10
of 56
pro vyhledávání: '"A B, Khodursky"'
Autor:
Andrea L Edwards, Dipen P Sangurdekar, Kyeong S Jeong, Arkady B Khodursky, Valentin V Rybenkov
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e84027 (2013)
MukB is a bacterial SMC (structural maintenance of chromosome) protein that regulates the global folding of the Escherichia coli chromosome by bringing distant DNA segments together. We report that moderate overproduction of MukB may lead, depending
Externí odkaz:
https://doaj.org/article/8e462ab7c13f49caad8854f0549c044b
Publikováno v:
Antimicrob Agents Chemother
Individual bacteria can escape killing by bactericidal antibiotics by becoming dormant. Such cells, also known as persisters, naturally occur in bacterial populations at a low frequency. Here we present the finding that antibiotic-resistance mutation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18004b839935e63f311bf25325730202
https://doi.org/10.1101/2020.08.19.258475
https://doi.org/10.1101/2020.08.19.258475
Publikováno v:
BMC Genomics
BMC Genomics, Vol 22, Iss 1, Pp 1-11 (2021)
BMC Genomics, Vol 22, Iss 1, Pp 1-11 (2021)
Background Enrichment or over-representation analysis is a common method used in bioinformatics studies of transcriptomics, metabolomics, and microbiome datasets. The key idea behind enrichment analysis is: given a set of significantly expressed gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db4f3fc996cc84872a6e0dacfd943b1f
https://pubmed.ncbi.nlm.nih.gov/33726670
https://pubmed.ncbi.nlm.nih.gov/33726670
Publikováno v:
PLoS Genetics, Vol 2, Iss 9, p e152 (2006)
Genetic and environmental perturbations often result in complex transcriptional responses involving multiple genes and regulons. In order to understand the nature of a response, one has to account for the contribution of the downstream effects to the
Externí odkaz:
https://doaj.org/article/4ada328fd62942e0b13a87905a19f899
Publikováno v:
International journal of antimicrobial agents. 53(3)
Fluoroquinolone (FQ)-resistant bacteria pose a major global health threat. Unanalysed genomic data from thousands of sequenced microbes likely contain important hints regarding the evolution of FQ resistance, yet this information lies fallow. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94a3594a51f20750a94a02b612514e72
https://pubmed.ncbi.nlm.nih.gov/30582984
https://pubmed.ncbi.nlm.nih.gov/30582984
Publikováno v:
Antimicrobial Agents and Chemotherapy. 60:6353-6355
Sensitization of resistant bacteria to existing antibiotics depends on the identification of candidate targets whose activities contribute to resistance. Using a transposon insertion library in an Escherichia coli mutant that was 2,000 times less sus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::205692ac46c8355cc011a96c1fa02a8d
https://doi.org/10.1128/aac.00889-16
https://doi.org/10.1128/aac.00889-16
Publikováno v:
Statistics in Biosciences. 4:300-318
Identifying which genes and which gene sets are differentially expressed (DE) under two experimental conditions are both key questions in microarray analysis. Although closely related and seemingly similar, they cannot replace each other, due to thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fafe88340e21723960499fc117961e57
https://doi.org/10.1007/s12561-012-9065-6
https://doi.org/10.1007/s12561-012-9065-6
Publikováno v:
Journal of the American Statistical Association. 106:61-72
Recent genomic studies have shown that significant chromosomal spatial correlation exists in gene expression of many organisms. Interestingly, coexpression has been observed among genes separated by a fixed interval in specific regions of a chromosom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9948b7cb4e51d14d96e56acd61436632
https://doi.org/10.1198/jasa.2010.ap09504
https://doi.org/10.1198/jasa.2010.ap09504
Publikováno v:
Biometrics. 65:805-814
In determining differential expression in cDNA microarray experiments, the expression level of an individual gene is usually assumed to be independent of the expression levels of other genes, but many recent studies have shown that a gene's expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb498804d43dafe53ed23458f0bf5f8d
https://doi.org/10.1111/j.1541-0420.2008.01161.x
https://doi.org/10.1111/j.1541-0420.2008.01161.x
Publikováno v:
Journal of Molecular Biology. 380:812-819
The Nun protein of coliphage HK022 excludes superinfecting lambda phage. Nun recognizes and binds to the N utilization (nut) sites on phage lambda nascent RNA and induces transcription termination. Overexpression of Nun from a high-copy plasmid is to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5062f1b2cea09d4edb01cdc723e41e6
https://doi.org/10.1016/j.jmb.2008.05.030
https://doi.org/10.1016/j.jmb.2008.05.030